Endothelial Cell News 3.26 July 30, 2018 | |
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TOP STORYScientists found that venous, capillary, and progenitor endothelial cells (ECs) responded to shear stress in vitro in a cilia-dependent manner. They then demonstrated that primary cilia assembly in human induced pluripotent stem cell-derived ECs varied between different cell lines with marginal influence of differentiation protocol. [Cell Rep] Full Article | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Exosomes from HNSCC Promote Angiogenesis through Reprogramming of Endothelial Cells Investigators evaluated in vitro and in vivo effects mediated by tumor-derived exosomes (TEX) that result in the promotion of angiogenesis. TEX produced by PCI-13 and UMSCC47 cell lines or head and neck squamous cell carcinoma (HNSCC) patients plasma were isolated by mini size exclusion chromatography. [Mol Cancer Res] Abstract To investigate whether endothelial progenitor cells (EPCs) participate in the restoration of hypoxia-affected myocardium, the authors used a co-culture model that allowed the intimate interaction between EPCs and myocardial slices, mimicking stem cell transplantation into the ischemic heart. [J Cell Mol Med] Abstract | Full Article Investigators determined whether urine‐derived stem cells could differentiate into functional endothelial cells in vitro. Urine-derived cells were then differentiated into cells of the endothelial lineage using endothelial differentiation medium for 14 days. [Stem Cells Transl Med] Abstract | Full Article Pigment Epithelium-Derived Factor (PEDF) as a Regulator of Wound Angiogenesis In vitro studies showed that PEDF inhibited migration and tube formation by dermal microvascular endothelial cells, and caused a decrease in the expression of VEGFR2, VCAM-1, and other surface receptors. [Sci Rep] Full Article Using a doxycycline-induced expression system of the intracellular domain of Notch1, researchers explored the role of Notch1 in the differentiation of embryonic stem cells to arterial endothelial cells. [Stem Cell Res Ther] Full Article Oleanolic acid was verified as a vascular endothelial growth factor (VEGF) receptor 2 (VEGFR-2) binding chemical from anticancer herbs with similar binding affinity as a reference drug in the Protein Data Bank entry 3CJG of model A coordination. Oleanolic acid effectively inhibited VEGF-induced VEGFR-2 activation and angiogenesis in HUVECs without cytotoxicity. [Mol Cells] Abstract The authors performed RNA sequencing on MPO-treated endothelial cells, analyzed their transcriptome and validated the profile of gene expression by individual qRT-PCR. [Arch Biochem Biophys] Abstract Effects of Light-Emitting Diodes Irradiation on Human Vascular Endothelial Cells Researchers investigated the effects of irradiation with light-emitting diodes at different wavelengths on human vascular endothelial cells in vitro. [Int J Impot Res] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSThe authors summarize the current field of machine perfusion strategies as applied to deceased donor liver transplantation and how therapeutic targeting of the liver sinusoidal endothelial cells may improve the quality of donor livers. [Semin Liver Dis] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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SCIENCE NEWSGenentech announced positive, top line results from the Phase II LADDER study evaluating the efficacy and safety of its investigational Port Delivery System with ranibizumab in people with wet AMD in the United States. [Press release from Genentech, Inc. discussing research presented at the 36th Annual Meeting of the American Society of Retina Specialists (ASRS), Vancouver] Press Release | |
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INDUSTRY NEWSOpthea Doses First Patient in Phase IIa Trial for OPT-302 in Diabetic Macular Edema Opthea Limited has successfully dosed the first patient in the Phase IIa randomized, controlled clinical trial evaluating the safety and efficacy of OPT-302 in patients with persistent center-involved diabetic macular edema. [Opthea Limited (GlobeNewswire, Inc.)] Press Release UC San Diego Researchers Receive Funding to Pursue Novel Stem Cell-Based Treatments The governing board of the California Institute for Regenerative Medicine unanimously approved two grants worth more than $2.2 million to University of California San Diego School of Medicine researchers investigating stem cell-based therapies for a rare genetic disorder that affects the heart and a chronic, progressive affliction of the lungs. [University of California San Diego School of Medicine] Press Release | |
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POLICY NEWSGovernment of Canada Further Strengthens Science and Encourages Scientists to Speak about Their Work Canadians count on federal scientists to produce the evidence needed to keep their air clean, their food safe and their water fresh. The Government of Canada is taking greater steps to ensure that this evidence is gathered without political or commercial interference. [Government of Canada] Editorial President Trump can add another tick in the records column: He doubled the length of time that any modern president has gone without a science adviser. [Washington Post] Editorial The UK and Indian governments signaled their commitment to a deeper relationship by jointly announcing four new awards worth £4.8 million under the Civil Nuclear Energy program and seven new awards worth £10.8 million under Phase 2 of the Global research program on health. [GOV.UK] Editorial New Evidence USCIS Policies Increased Denials of H-1B Visas New data show that in 2017, U.S. Citizenship and Immigration Services (USCIS) denied many more H-1B petitions and issued numerous costly Requests for Evidence to stop highly educated foreign nationals from working in America. [Forbes Media LLC] Editorial Third Retraction for Harvard Cancer Biologist Nature has issued a retraction of a cancer study, seven years after its publication, citing issues with two figures and the unavailability of original data for them. The paper, led by Harvard Medical School biologist Sam Lee, is among several publications from his group to be retracted. [The Scientist] Editorial
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EVENTSNEW European Society for Microcirculation (ESM)-European Vascular Biology Organisation (EVBO) Meeting 2019 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Scientist – Corneal Cells (The Veneto Eye Bank Foundation) NEW Postdoctoral Research Assistant – Cancer and Vascular Biology (University of Oxford) Research Technologist – Endothelial Cell Biology (STEMCELL Technologies Inc.) Postdoctoral Position – Cancer Metabolism by Blood Vessels (German Cancer Research Center) Postdoctoral Fellow – Cardiovascular Stem Cell Biology (University of Illinois at Chicago) Postdoctoral Associate – Biomedical Engineering (University of Minnesota) Postdoctoral Fellow – Vascular and Endothelial Cell Biology (Augusta University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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