Endothelial Cell News 3.30 September 10, 2018 | |
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TOP STORYRole of Glutamine Synthetase in Angiogenesis beyond Glutamine Synthesis Researchers showed that in human umbilical vein endothelial cells GLUL knockdown reduced membrane localization and activation of the GTPase RHOJ while activating other Rho GTPases and Rho kinase, thereby inducing actin stress fibres and impeding endothelial cell motility. [Nature] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Piezo1 and Gq/G11 Promote Endothelial Inflammation Depending on Flow Pattern and Integrin Activation Investigators showed that both laminar and disturbed flow activated the same initial pathway involving the mechanosensitive cation channel Piezo1, the purinergic P2Y2 receptor, and Gq/G11-mediated signaling. However, only disturbed flow led to Piezo1- and Gq/G11-mediated integrin activation resulting in focal adhesion kinase-dependent NF-κB activation. [J Exp Med] Abstract Scientists demonstrated that intracellular high mobility group box 1 (HMGB1) could be released from perihilar cholangiocarcinoma (PHCCA) cells and induce invasion and angiogenesis with LPS stimulation. VEGFR2 expression in vessel endothelial cells was upregulated by the released HMGB1 from PHCCA, resulting in the ectopic angiogenesis. [Oncogene] Abstract WTAPP1 positively regulated migration, invasion, and in vitro and in vivo tube formation in endothelial progenitor cells by increasing MMP-1 expression and activating PI3K/Akt/mTOR signaling. Suppression of WTAPP1 by miR-3,120-5P decreased the level of MMP-1. [Stem Cells] Abstract Perfused 3D Angiogenic Sprouting in a High-Throughput In Vitro Platform The authors describe an in vitro platform that integrated both perfusion and the generation of stable biomolecular gradients and demonstrated its potential to study more physiologically relevant angiogenic sprouting and microvascular stabilization. [Angiogenesis] Full Article Endothelial progenitor cells (EPCs) secreted TGF-β1 in the EPC-bone marrow-derived macrophage (BMM) co-culture medium and increased Talin-1 expression in the co-cultured BMMs. Treatment with a TGF-β1 neutralizing antibody or Talin-1 silencing in BMMs completely inhibited BMM osteoclastic differentiation in the co-culture system. [Cell Physiol Biochem] Full Article Scientists found that triple phosphomimetic mutant-pigment epithelium-derived factor (PEDF) suppressed endothelial cell (EC) proliferation due to caspase-3-dependent apoptosis, and also inhibited migration of ECs much better than wildtype-PEDF. [Cell Physiol Biochem] Full Article Investigators showed that both membrane-bound IL-6 receptor (IL-6R) and gp130 were expressed on the surface of human vascular endothelial cells, and that the expression was affected by pro-inflammatory stimuli. In contrast to IL-6 classic signaling, IL-6 trans-signaling induced the release of the pro-inflammatory chemokine monocyte chemoattractant protein-1 from human vascular endothelial cells. [Cell Commun Signal] Full Article SNHG12 Promotes Angiogenesis following Ischemic Stroke via Regulating miR-150/VEGF Pathway Researchers found long-noncodingRNA small nucleolar RNA host gene 12 (SNHG12) expression was elevated, whereas miR-150 was reduced in oxygen-glucose deprivation (OGD)-exposed bEnd.3 cells. Upregulation of SNHG12 elevated, and SNHG12 knockdown suppressed the capillary-like tube formation, viability, migration, and VEGF expression in OGD-injured bEnd.3 cells. [Neuroscience] Abstract Scientists investigated a possible mechanism of action of metronomic chlorambucil on glioma by studying the in vitro cytotoxicity and anti-angiogenic effects on glioma and endothelial cells, respectively. [PLoS One] Full Article Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSExtracellular Matrix Scaffolding in Angiogenesis and Capillary Homeostasis The authors focus on the unique molecular composition and scaffolding of the capillary extracellular matrix, which provides structural support to blood vessels and regulates properties of endothelial cells and pericytes. [Semin Cell Dev Biol] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSHutchison MediPharma (HMP) announced that fruquintinib capsules have been granted approval for drug registration by the National Medical Products Administration of China for the treatment of metastatic colorectal cancer patients, who have failed at least two prior systemic antineoplastic therapies including fluoropyrimidine, oxaliplatin and irinotecan, with or without prior use of anti-VEGF or anti-epidermal growth factor receptor therapies. [Hutchison MediPharma Limited] Press Release Eisai Co., Ltd. and Merck announced that the NMPA approved the kinase inhibitor LENVIMA® as a single agent for the treatment of patients with unresectable HCC who have not received prior systemic therapy. [Merck & Co., Inc.] Press Release Kodiak Sciences Inc. announced that enrollment of patients in the company’s Phase I safety and tolerability study has been completed. The primary objectives of the Phase I study are to evaluate ocular and systemic safety and to establish a maximum tolerated dose of KSI-301. [Kodiak Sciences Inc.] Press Release $3 Million Grant Will Fund New 3D Map of Brain’s Blood Vessels In an upcoming project, a team of Pennsylvania State University researchers will use mice as a model for creating high-resolution, 3D maps of the blood vessels in both young and aging brains. The researchers hope learning more about healthy brains will help them learn more about how problems — like strokes or Alzheimer’s disease — develop over time. [The Pennsylvania State University] Press Release | |
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POLICY NEWSPeer Reviewers in Developing Nations Are Underrepresented, Report Suggests Combined, scientists spend nearly 70 million hours peer reviewing manuscripts for scholarly journals every year, a new report says. But too much of the onus rests on researchers in wealthy countries, according to the report by the company Publons—based in London and Wellington—which enables researchers to track and claim credit for the peer reviews they perform. [ScienceInsider] Editorial Pivotal CRISPR Patent Battle Won by Broad Institute The US Court of Appeals for the Federal Circuit awarded the pivotal intellectual property to the Broad Institute of Cambridge, Massachusetts, upholding a previous decision by the US Patent and Trademark Office. The decision spells defeat for a team of inventors that includes molecular biologist Jennifer Doudna University of California, Berkeley. [Nature News] Editorial AACR Apologizes for Delays in Retracting Papers The American Association for Cancer Research (AACR) has issued retractions, corrections, or editor’s notes for a handful papers across five of its journals and is sorry for the time it’s taken to do so, according to a statement published in Cancer Research. [The Scientist] Editorial The Trump administration’s restrictions on hiring foreign scientists are making it more difficult for the agency to attract top scientific talent, a top FDA official said. “[The policy] definitely has created an additional challenge, I think, for us,” said Melanie Keller, the FDA’s acting associate commissioner for scientific and clinical recruitment. [STAT News] Editorial
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EVENTSNEW Gordon Research Conference: Angiogenesis 2019 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Scholar – Vascular Dysfunction in Sepsis (Medical University of South Carolina) Faculty Positions – Cardiovascular Research (Nationwide Children’s Hospital, Research Institute) Postdoctoral Fellow – Lymph Node Vasculature (Uppsala University) Postdoctoral Fellow – Pulmonary Arterial Hypertension (National Institutes of Health) Scientist – Cardiovascular Research (University of Iowa Hospital and Clinics) Senior Postdoctoral Research Position – Cardiovascular Research (University of Tennessee) Research Scientist – Corneal Cells (The Veneto Eye Bank Foundation) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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