Endothelial Cell News 3.34 October 15, 2018 | |
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TOP STORYResearchers revealed that neuroendocrine differentiation (NED) and angiogenesis were molecularly connected through enhancer of zeste homolog 2 (EZH2). NED and angiogenesis were both regulated by androgen-deprivation therapy-activated cAMP response element-binding protein (CREB) that in turn enhanced EZH2 activity. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Distinct Roles of VE-Cadherin for Development and Maintenance of Specific Lymph Vessel Beds During development, VE-cadherin deletion in lymphatic endothelial cells resulted in abortive lymphangiogenesis, edema, and prenatal death. Unexpectedly, inducible postnatal or adult deletion elicited vessel bed-specific responses. [EMBO J] Abstract | Graphical Abstract In human retinal endothelial cells, expression of eVEGF-38, eVEGF-53, or VEGF189 increased VEGFR2 phosphorylation without increasing expression of pro-inflammatory markers, relative to VEGF165 protein and vector controls. [Cell Death Dis] Full Article Primary Rat LSECs Preserve their Characteristic Phenotype after Cryopreservation Scientists report a protocol to cryopreserve rat liver sinusoidal endothelial cells (LSECs) that, upon thawing, maintain full LSEC-signature features: fenestrations, scavenger receptor expression and endocytic function on par with freshly isolated cells. [Sci Rep] Full Article CX3CR1 Differentiates F4/80low Monocytes into Pro-Inflammatory F4/80high Macrophages in the Liver Hepatic and splenic CX3CR1lowF4/80low monocytes and CX3CR1lowCD16− monocytes were differentiated into CX3CR1highF4/80high or CX3CR1highCD16+ macrophages by co-culture with endothelial cells. [Sci Rep] Full Article Scientists investigated the role X-box binding protein l splicing (XBP1s) plays in brain microvascular endothelial cell (BMEC) proliferation and angiogenesis following cerebral ischemia. The roles of XBP1s on cell survival, apoptosis, cycle migration, and angiogenesis were determined in oxygen-glucose deprivation treated BMECs. [J Cell Physiol] Abstract Researchers revealed that in human blood vessels the clinically-relevant high concentration of homocysteine directly caused endothelial dysfunction by downregulating eNOS protein that may be reversed by AVE3085. [Nitric Oxide] Abstract Investigators determined the effects of amitriptyline on angiogenic capability of vascular endothelial cells in physiological settings and identified its mechanism of action. [Basic Clin Pharmacol Toxicol] Abstract Lymphatic Endothelial Cells Promote Productive and Latent HIV Infection in Resting CD4+ T Cells The authors investigated the effects of microvascular endothelial cell stimulation of resting CD4+ T cells in establishing viral infection and latency. [Virol J] Full Article Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSThe Role of Angiogenesis in Hepatocellular Carcinoma Hepatocellular carcinoma (HCC) accounts for about 90% of all primary liver cancers and is the second leading cause of cancer-related deaths worldwide. The hypervascular nature of most HCC tumors underlines the importance of angiogenesis in the pathobiology of these tumors. [Clin Cancer Res] Abstract | Full Article Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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SCIENCE NEWSREGENXBIO Inc. announced it has completed dosing of the fourth cohort of six patients in a Phase I clinical trial evaluating RGX-314 for the treatment of wet age-related macular degeneration. [Press release from REGENXBIO Inc. discussing research presented at the American Academy of Ophthalmology (AAO) 2018 Annual Meeting, Chicago] Press Release | |
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INDUSTRY NEWSAvalon GloboCare Corp. announced that Weill Cornell Medicine has selected its subsidiary Genexosome Technologies’ proprietary exosome isolation system as a key component in the world’s first standardization processing of cGMP-grade exosomes for clinical studies. [Avalon GloboCare Corp.] Press Release Exelixis, Inc. announced the initiation of a Phase IIII pivotal trial of single-agent cabozantinib in patients with radioiodine-refractory differentiated thyroid cancer who have progressed after up to two prior vascular endothelial growth factor receptor (VEGFR)-targeted therapies. [Exelixis, Inc.] Press Release NIH Awards Allele with Grant for the Development of Nanoantibody Therapies for Treating Sepsis The National Institute of General Medical Sciences of NIH has awarded a Small Business Innovative Research grant to Allele Biotechnology and Pharmaceuticals to develop new single-domain nanoantibody therapies for the treatment of sepsis. [Allele Biotechnology & Pharmaceuticals Inc. (Business Wire, Inc.)] Press Release | |
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POLICY NEWSThe UK Pharmaceutical Industry Braces for Brexit As Britain’s departure date from the European Union approaches, drugmakers are preparing for potential changes to regulatory procedures and border controls. [The Scientist] Editorial Argentina’s Scientists Struggle amid Slipping Peso and Rising Inflation Researchers have struggled under austerity measures adopted by the government in 2014 and intensified in June by a financing agreement that Argentina signed with the International Monetary Fund. [Nature News] Editorial
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EVENTSNEW NAVBO: Vascular Biology 2019 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Associate – Innate Immunity and Inflammation (University of Illinois) NEW Postdoctoral Position – Receptor Expression in the Blood-Brain Barrier (Aarhus University) NEW Postdoctoral Fellow – Vascular Research (Johns Hopkins University School of Medicine) Postdoctoral Fellow – Vascular Development (University of Colorado Denver) Group Leader – Vascular Research (Helmholtz Zentrum München) Group Leader – In Vitro Vascular Systems (European Molecular Biology Laboratory) Postdoctoral Fellow – Vascular and/or Lung Biology (Yale University) Postdoctoral Scientists – Vascular Diseases (Oklahoma Medical Research Foundation) Postdoctoral Scholar – Vascular Dysfunction in Sepsis (Medical University of South Carolina) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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