Endothelial Cell News 3.35 November 22, 2018 | |
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TOP STORYResearchers showed that oscillatory shear stress activated autocrine Wnt/β-catenin signaling in lymphatic endothelial cells (LECs) in vitro. Tissue-specific deletion of Wntless, which is required for the secretion of Wnt ligands, revealed that LECs and vascular smooth muscle cells were complementary sources of Wnt ligands that regulate lymphatic vascular development in vivo. [Cell Rep] Full Article | Press Release | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)The authors indicated that Andrographolide (Andro) could significantly inhibit the proliferation of human breast cancers, and suppress COX-2 expression at both protein and mRNA levels. Furthermore, Andro could dose-dependently inhibit COX-2-mediated angiogenesis in human endothelial cells. [J Exp Clin Cancer Res] Full Article Scientists characterized the potential endothelium-protective effects of circulating epicatechin metabolites and defined underlying mechanisms of action by an integrated systems biology approach. [Sci Rep] Full Article Researchers revealed that the exchange protein directly activated by cAMP 1 (EPAC1) gene deletion protected vasculature in ex vivo explants from Ebola virus infection. Importantly, pharmacological inhibition of EPAC1 using EPAC-specific inhibitors mimicked the EPAC1 knockout phenotype in the ex vivo model. [Viruses] Full Article Investigators revealed that the expression of IL-6 and IL-8 in hemangioma cells were significantly increased as compared with that in human umbilical vein endothelial cells. [Eur J Pharmacol] Abstract Scientists examined the radioprotective effect of polydatin on crypt and endothelial cells of the small intestines of C57BL/6 mice that received abdominal irradiation. [Biosci Rep] Abstract | Full Article MicroRNA-575 Suppresses Angiogenesis by Targeting Rab5-MEK-ERK Pathway in Endothelial Cells Overexpression of miR-575 in human umbilical vein endothelial cells (HUVECs) by its mimics significantly inhibited migration and proliferation as well as induction of apoptosis of HUVECs. Inhibition of miR-575 performed the reverse effects of HUVECs. [Biosci Rep] Abstract | Full Article Researchers investigated the expression of glycosaminoglycans, proteoglycans and other extracellular matrix molecules in endothelial cells subjected to various mechanical stimuli. [Life Sci] Abstract Scientists investigated the effect of miR-150 on endothelial progenitor cells (EPCs) function ex vivo and thrombus resolution in vivo. They determined miR-150 expression in EPCs isolated from deep venous thrombosi patients and control subjects by RT-PCR. [Microvasc Res] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSConvergence of VEGF and YAP/TAZ Signaling: Implications for Angiogenesis and Cancer Biology The authors explain the pathophysiological roles of vascular endothelial growth factor (VEGF) and YAP/TAZ, identify their connections to other receptor-mediated pathways, and reveal ways of therapeutically targeting their convergent signals in patients. [Sci Signal] Full Article Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSLSK BioPharma and Jiangsu Hengrui Medicine, Co., Ltd. announced that the companies have entered into a global clinical collaboration in patients with advanced HCC, evaluating the safety and efficacy of LSKB’s rivoceranib, a selective and potent VEGFR-2 inhibitor, in combination with Hengrui’s camrelizumab, a humanized anti-PD-1 monoclonal antibody currently under NDA review in China for classic Hodgkin’s Lymphoma. [LSK BioPharma] Press Release Engineers Drawn to Stem Cells’ Abundance, Humanity There was a time when Eric Shusta’s lab was more reliant on the local butcher shop than you might expect. To learn more about the blood-brain barrier — the cellular wall between the open ocean of the bloodstream and the protected confines of the brain — and how to trick the body into letting foreign molecules through the barrier’s gates, Shusta needed brains. [University of Wisconsin-Madison] Editorial | |
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POLICY NEWSBritish Universities Set Up European Outposts as Brexit Looms Some of Britain’s leading research institutions are establishing alliances with counterparts in other European countries — a move that might allow them to keep drawing on the EU’s science funds even in the case of a ‘no-deal’ divorce from the bloc, a more extreme form that Brexit could take. [Nature News] Editorial UK’s Science Reputation ‘at Risk if Academic Visa Issues Not Resolved’ The Wellcome Trust, which grants more than £1bn for research each year, said the immigration system was “not up to scratch” after another scientific summit in the UK was marred by the visa barriers delegates and speakers faced. [The Guardian] Editorial Cancer Research to Cut Funding for Scientists Who Bully Colleagues Britain’s largest cancer charity has announced new rules to crack down on bullying and harassment. Cancer Research UK said scientists who bullied or harassed colleagues would face sanctions that could include being prevented from supervising PhD students, losing funding from the charity or being barred from applying for future grants. [The Guardian] Editorial
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EVENTSNEW The 5th Canadian Cancer Research Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPostdoctoral Research Associate – Innate Immunity and Inflammation (University of Illinois) Postdoctoral Position – Receptor Expression in the Blood-Brain Barrier (Aarhus University) Postdoctoral Fellow – Vascular Research (Johns Hopkins University School of Medicine) Postdoctoral Fellow – Vascular Development (University of Colorado Denver) Group Leader – Vascular Research (Helmholtz Zentrum München) Group Leader – In Vitro Vascular Systems (European Molecular Biology Laboratory) Postdoctoral Fellow – Vascular and/or Lung Biology (Yale University) Postdoctoral Scientists – Vascular Diseases (Oklahoma Medical Research Foundation) Postdoctoral Scholar – Vascular Dysfunction in Sepsis (Medical University of South Carolina) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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