Endothelial Cell News Volume 3.36 | Oct 29 2018

TOP STORY

Testicular Endothelial Cells Are a Critical Population in the Germline Stem Cell Niche

Researchers showed that testicular endothelial cells are part of the spermatogonial stem cell niche (SSC) producing glial cell line-derived neurotrophic factor and other factors to support human and mouse SSCs in long-term culture. [Nat Commun] Full Article | Press Release

(Ranked by impact factor of the journal)

Adhesion to Nanofibers Drives Cell Membrane Remodeling through One-Dimensional Wetting

Remodeling of the plasma membrane of endothelial cells by the bacterium Neisseria meningitidis is thought to be essential during the blood phase of meningococcal infection, but the underlying mechanisms are unclear. Investigators showed that plasma membrane remodeling occured independently of F-actin, along meningococcal type IV pili fibers, by a physical mechanism that they termed ‘one-dimensional’ membrane wetting. [Nat Commun] Full Article

Circular RNA Transcriptomics Analysis of Primary Human Brain Microvascular Endothelial Cells Infected with Meningitic Escherichia coli

Scientists used high-throughput sequencing to analyze the transcriptional profiles of host circular RNAs in primary brain microvascular endothelial cells in response to meningitic E. coli. [Mol Ther Nucleic Acids] Abstract | Full Article

Endothelial Cells Release Cardioprotective Exosomes That May Contribute to Ischaemic Preconditioning

The authors hypothesized that exosomes from endothelial cells can transmit protective signals to cardiomyocytes. Co-culture of primary adult rat cardiomyocytes with normoxic HUVEC cells separated by a cell-impermeable membrane reduced the percentage of cardiomyocyte death following simulated ischaemia and reperfusion from 80 ± 11% to 51 ± 4%. [Sci Rep] Full Article

Female Mice Have Higher Angiogenesis in Perigonadal Adipose Tissue than Males in Response to High-Fat Diet

When placed on a high-fat diet, female mice gained less weight than males and showed a metabolic phenotype similar to normal chow-fed mice, contrasting with the impaired whole-body glucose metabolism observed in high-fat-fed males. [Front Physiol] Full Article | Press Release

Copper(II) bis(diethyldithiocarbamate) Induces the Expression of Syndecan-4, a Transmembrane Heparan Sulfate Proteoglycan, via p38 MAPK Activation in Vascular Endothelial Cells

Scientists hypothesized that copper(II) bis(diethyldithiocarbamate) may regulate the expression of proteoglycans and examined this hypothesis using a bovine aortic endothelial cell culture system. [Int J Mol Sci] Full Article

Erbin Plays a Critical Role in Human Umbilical Vein Endothelial Cell Migration and Tubular Structure Formation via the Smad1/5 Pathway

Although knockdown of Erbin did not affect HUVEC proliferation and apoptosis, it significantly suppressed HUVEC migration and tubular structure formation. Erbin knockdown showed no effect on the ERK1/2 and Smad2/3 signaling pathways but significantly promoted Smad1/5 phosphorylation and nuclear translocation. [J Cell Biochem] Abstract

Urea‐Modulated UT‐B Urea Transporter Internalization Is Clathrin‐ and Caveolae‐Dependent in Infantile Hemangioma‐Derived Vascular Endothelial Cells

Researchers investigated the manner of urea‐modulated UT‐B urea transporter internalization in infantile hemangioma‐derived vascular endothelial cells. [J Cell Biochem] Abstract

Ets-1 Drives Breast Cancer Cell Angiogenic Potential and Interactions between Breast Cancer and Endothelial Cells

Ets-1 emerged as a key regulator of the angiogenic potential of breast cancer cells, favoring their ability to induce, in a paracrine manner, the morphogenesis of endothelial cells and also to physically interact with the latter. Nevertheless, Ets-1 overexpression in cancer cells also restrained their chemoattractive potential for endothelial cells both in Boyden chambers and in ex vivo 3D co-cultures. [Int J Oncol] Abstract

Cell Chirality Regulates Intercellular Junctions and Endothelial Permeability

Scientists demonstrated that cell chirality accounted for the nonmonotonic, dose-response relationship between endothelial permeability and protein kinase C activation. [Sci Adv] Full Article | Press Release

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Intrinsic Vascular Repair by Endothelial Progenitor Cells in Acute Coronary Syndromes: An Update Overview

The authors give an overview on endothelial progenitor cell (EPC)-mediated vascular repair with special focus on acute coronary syndromes and discuss the different phenotypic profiles that have been used to identify and quantify circulating EPCs in several clinical studies. [Stem Cell Rev] Abstract

Visit our reviews page to see a complete list of reviews in the endothelial cell research field.

EYLEA^® (Aflibercept) Injection Improves Diabetic Retinopathy and Reduces Vision-Threatening Complications in Phase III Trial

Regeneron Pharmaceuticals, Inc. announced that the Phase III PANORAMA trial evaluating EYLEA^® Injection in patients with moderately severe and severe non-proliferative diabetic retinopathy met its one-year primary endpoint and key secondary endpoints. [Regeneron Pharmaceuticals, Inc.] Press Release

Humacyte Commences Phase II Vascular Trauma Trial

Humacyte announced the initiation of a U.S. Phase II vascular trauma clinical trial of HUMACYL^®, its investigational human acellular vessel, for vascular replacement or reconstruction in patients with life- or limb-threatening vascular trauma. [Humacyte, Inc.] Press Release

‘Tropical Trump’ Victory in Brazil Stuns Scientists

Former military officer Jair Bolsonaro rode a wave of anti-establishment anger to victory in Brazil’s presidential election, leaving many researchers stunned and worried about the future of their country. [Nature News] Editorial

Embattled University Switches Countries in the Face of Controversial Law

An international university in Budapest that has been at the center of a struggle between Hungarian liberals and the country’s right-wing government has decided to transfer its next batch of master’s and doctoral students to Austria. [Nature News] Editorial

NEW 15^th Annual Stem Cell Symposium: Stem Cells B2B – Bench to Bedside
February 1, 2019
Los Angeles, California, United States

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Endothelial Cell Research (University of Missouri)

Postdoctoral Position – Molecular/Cell Biology of Neurodegeneration and Alzheimer’s Disease (Icahn School of Medicine at Mount Sinai)

Postdoctoral Research Associate – Innate Immunity and Inflammation (University of Illinois)

Postdoctoral Research Associate – Endothelial Barrier Function, Angiogenesis and Cancer Metastasis (University of Illinois at Chicago)

Postdoctoral Fellow – Vascular Research (Johns Hopkins University School of Medicine)

Postdoctoral Fellow – Vascular Development (University of Colorado Denver)

Group Leader – Vascular Research (Helmholtz Zentrum München)

Group Leader – In Vitro Vascular Systems (European Molecular Biology Laboratory)

Postdoctoral Fellow – Vascular and/or Lung Biology (Yale University)

Postdoctoral Scientists – Vascular Diseases (Oklahoma Medical Research Foundation)

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