Endothelial Cell News 3.42 December 17, 2018 | |
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TOP STORYaPKC Controls Endothelial Growth by Modulating C-Myc via FoxO1 DNA-Binding Ability Researchers showed that atypical protein kinase C lambda/iota (aPKCλ) phosphorylated the DNA binding domain of forkhead box O1 (FoxO1) transcription factor, a gatekeeper of endothelial growth. Although mitogenic signaling excluded FoxO1 from the nucleus, consequently increasing c-Myc abundance and proliferation, aPKCλ controlled c-Myc expression via FoxO1/miR-34c signaling without affecting its localization. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Using cybrids constructed by transferring mitochondria from a Chinese family carrying the m.15927G>A mutation and a control into mitochondrial DNA-less human umbilical vein endothelial cells, researchers demonstrated that the m.15927G>A mutation caused significantly decreased efficiency in aminoacylation and steady-state levels of tRNAThr. [Nucleic Acids Res] Full Article Interleukin-22 Promotes Tumor Angiogenesis Interleukin-22 (IL-22) induced endothelial cell proliferation, survival, and chemotaxis in vitro and neovascularization in an ex vivo mouse choroid explant model. Blockade of IL-22, with a neutralizing antibody, significantly inhibited tumor growth associated with reduced microvascular density. No synergistic effect of IL-22 with VEGF was observed. [Angiogenesis] Abstract siRNA-mediated knockdown of transcription factor activating enhancer binding protein-2 (TFAP2) B in corneal endothelial cells decreased the expression of the corneal endothelium-specific proteins type VIII collagen alpha 2 and zone pellucida glycoprotein 4 and suppressed cell proliferation. [J Biol Chem] Abstract | Full Article The authors investigated the effects of microRNA-212 on the recovery function and vascular regeneration of endothelial progenitor cells by inactivation of the Notch signaling pathway by binding to matrix metallopeptidase 9 (MMP9) in mice with ischemic stroke. [J Cell Physiol] Abstract CCK8 assay and flow cytometry analysis showed that galectin-3 (Gal-3) significantly decreased cell viability and promoted apoptosis in oxidized low-density lipoprotein (ox-LDL)-treated HUVECs. The upregulation of integrinβ1, GTP-RhoA, p-JNK, p-p65, p-IKKα, and p-IKKβ induced by ox-LDL was further enhanced by treatment with Gal-3. [J Cell Physiol] Full Article Loss of Multimerin-2 and EMILIN-2 Expression in Gastric Cancer Associate with Altered Angiogenesis Investigators analyzed the expression of multimerin-2, EMILIN-2 and EMILIN-1, three molecules of the EMI Domain ENdowed (EDEN) protein family. These molecules played important functions in the tumor microenvironment, affecting cancer progression both directly and indirectly impinging on angiogenesis and lymphangiogenesis. [Int J Mol Sci] Full Article PACAP through EGFR Transactivation Preserves Human Corneal Endothelial Integrity Researchers showed the expression of pituitary adenylate cyclase–activating polypeptide (PACAP) and its receptor (PAC1R) in human corneal endothelium and demonstrated that this peptide, selectively binding to PAC1R, induced epidermal growth factor receptor (EGFR) phosphorylation and MAPK/ERK1/2 signaling pathway activation. [J Cell Biochem] Abstract Scientists used in situ hybridization and quantitative PCR to determine AZIN2-splice variant (sv) expression in endothelial cells. Knockdown and overexpression were performed to detect the role of AZIN2-sv in endothelial cell function, angiogenesis and prognosis after myocardial infarction. [EBioMedicine] Full Article | Graphical Abstract Investigators report that neuropilin-1 (NRP1) promoted mitochondrial function in endothelial cells (ECs) by preventing iron accumulation and iron-induced oxidative stress through a VEGF-independent mechanism in non-angiogenic ECs. Furthermore, NRP1-deficient ECs had reduced growth and show the hallmarks of cellular senescence. [iScience] Full Article Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSHow Many Cadherins Do Human Endothelial Cells Express? The authors review gene and protein expression databases to analyze cadherin expression in mature human endothelium and find that at least 24 cadherin superfamily members are significantly expressed. They discuss their potential functions, many of them unrelated to the formation of endothelial cell-cell junctions. [Cell Mol Life Sci] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSAVEO Oncology Announces Immuno-Oncology Clinical Collaboration with AstraZeneca AVEO Oncology announced that it has entered into a clinical collaboration with AstraZeneca to evaluate the safety and efficacy of AstraZeneca’s IMFINZI®, a human monoclonal antibody directed against programmed death-ligand 1 (PD-L1), in combination with FOTIVDA®, AVEO’s oral, once-daily, potent and highly-selective VEGF receptor tyrosine kinase inhibitor in first-line hepatocellular carcinoma, or liver cancer, in a Phase I/II study. [AVEO Oncology] Press Release Innovent Biologics, Inc. announced that IBI305, a recombinant humanized anti-VEGF monoclonal antibody being developed as a potential biosimilar to Avastin, has met pre-defined primary endpoints in two randomized, head to head, clinical trials comparing IBI305 versus branded bevacizumab: a Phase III clinical trial in patients with advanced non-squamous non-small cell lung cancer and a pharmacokinetic study in healthy subjects. [Innovent Biologics, Inc.] Press Release | |
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POLICY NEWSUniversity of California and Elsevier Locked in Negotiations The University of California (UC) is pushing back against the publishing giant Elsevier over fees and access to research papers. The UC system’s five-year contract expires on December 31 and it has prepared for faculty and students to lose access Elsevier’s journals if they don’t reach an agreement in time. [The Scientist] Editorial NIH Report Scrutinizes Role of China in Theft of U.S. Scientific Research Institutions across the U.S. may have fallen victim to a tiny fraction of foreign researchers who worked to feed American intellectual property to their home countries, an advisory committee to the National Institutes of Health (NIH) found in a report. [STAT News] Editorial China Introduces ‘Social’ Punishments for Scientific Misconduct Researchers in China who commit scientific misconduct could soon be prevented from getting a bank loan, running a company or applying for a public-service job. The government has announced an extensive punishment system that could have significant consequences for offenders — far beyond their academic careers. [Nature News] Editorial
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EVENTSNEW Tissue Engineering & Regenerative Medicine International Society – AP Chapter and the 7th Asian Biomaterials Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Tenure Track Faculty Position – Department of Cancer Biology (KUMC) Postdoctoral Fellow – Zebrafish Vascular Biology (NYU Langone Medical Center) Postdoctoral Position – Molecular Neurobiology (San Raffaele Scientific Institute) Postdoctoral Fellow – Pulmonary Arterial Hypertension (National Institutes of Health) Faculty Positions – Lung and Vascular Biology (Northwestern University) Senior Research Assistant – Genitourinary Medical Oncology (MD Anderson Cancer Center) Assistant/Associate Adjunct Professor – Cardiovascular Medicine (UC Davis) Postdoctoral Positions – Angiogenesis and Vascular Metabolism (VIB) Postdoctoral Research Associate – Endothelial Cell Research (University of Illinois) Postdoctoral Positions – Cell/Developmental/Vascular Biology (Uppsala University) Postdoctoral Fellow – Endothelial Cell Research (University of Missouri) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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