Endothelial Cell News 4.11 April 1, 2019 | |
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TOP STORYEndothelial cells at the bone/cartilage interface supported vessel-associated osteoclasts through a RANKL-RANK signaling mechanism. Remarkably, proteinases including matrix metalloproteinase-9 released from endothelial cells, not osteoclasts, were essential for resorbing cartilage to lead directional bone growth. [Nat Cell Biol] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)To identify activated pathways downstream of VEGFR2, researchers performed whole-genome transcriptomics and secretome analyses, and found that the Notch and ErbB pathways were involved in transducing signals for endothelial cell-cardiomyocyte crosstalk in response to angiogenesis. [Circulation] Abstract Shear-Induced CCN1 Promotes Atheroprone Endothelial Phenotypes and Atherosclerosis CCN1-regulated functional phenotypes of HUVECs, or primary mouse aortic endothelial cells isolated from wild-type and Ccn1dm/dm mice were investigated in the in vitro shear stress experiments under unidirectional laminar shear stress vs. oscillatory shear stress conditions. [Circulation] Abstract Scientists observed a substantial influx of alpha smooth muscle actin-expressing cells into the human acellular vessel (HAV) that progressively matured and circumferentially aligned in the HAV wall. These cells were supported by microvasculature initially formed by CD34+/CD31+ cells in the neoadventitia and later maintained by CD34−/CD31+ endothelial cells in the media and lumen of the HAV. [Sci Transl Med] Abstract | Press Release | Editorial Endothelial Sox17 Promotes Allergic Airway Inflammation Researchers used ovalbumin to induce airway inflammation in endothelium-specific Sry-related high-mobility-group box (Sox) 17 null mutant mice, and utilized interleukin (IL)-33 neutralizing antibody to evaluate the interplay between IL-33 and Sox17. They also carried out loss- or gain-of-function experiments for Sox17 in human endothelial cells. [J Allergy Clin Immunol] Abstract | Graphical Abstract Quaking (QKI) supported endothelial cell (EC) function by stabilizing cyclin D1 (CCND1) mRNA to promote EC G1/S cell cycle transition and proliferation. Both nanoparticle-mediated RNA interference of endothelial QKI expression and palbociclib blockade of CCND1 function potently inhibited metastasis in concert with significant effects on tumor vasculature. [Oncogene] Abstract Investigators demonstrated that a specific locus in the promoter region of the ITPR3 gene was essential for KLF4 binding, acetylation of histone 3 lysine 27 enrichment, chromatin accessibility, RNA polymerase II recruitment, and ITPR3 transcriptional activation. Deletion of this KLF4 binding locus in endothelial cells by using CRISPR-Cas9 resulted in blunted calcium influx, reduced expression of endothelial nitric oxide synthase, and diminished nitric oxide bioavailability. [Arterioscler Thromb Vasc Biol] Abstract Scientists evaluated the mechanisms governing the HIF switch in ten different primary human endothelial cells from different vascular beds during the early stages of hypoxia. They demonstrated that the switch from HIF-1 to HIF-2 constituted a universal mechanism of cellular adaptation to hypoxic stress and that HIF1A and HIF2A mRNA stability differences contributed to the HIF switch. [FASEB J] Abstract High glucose (HG) increased sodium glucose co-transporter2 (SGLT2) and 2 protein levels in cultured endothelial cells (ECs) and native endothelium. Inhibition of the angiotensin system prevented HG-induced EC senescence and SGLT1 and 2 expression. [J Cell Mol Med] Full Article 3D endothelial cell networks were generated by using HUVECs in combination with human adipose tissue derived stromal cells employing human collagen I as hydrogel and decellularized porcine small intestinal submucosa as starter matrix. [Sci Rep] Full Article Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSP66Shc and Vascular Endothelial Function A significant understanding has been developed with respect to the molecular signaling regulating the oxidative function of p66Shc in endothelial cells and its targets and regulators. In addition, novel regulatory modifications of p66Shc controlling its oxidative function, sub-cellular distribution and stability have also been reported. The author focuses on summarizing the molecular signaling regulating the oxidative function of p66Shc and its role in vascular endothelium. [Biosci Rep] Abstract | Full Article Further research into understanding the mechanisms by which the splicing of VEGF-A/VEGFR-1/VEGFR-2 is regulated will help in the development of drugs aimed at manipulating splicing or inhibiting specific splice isoforms in a therapeutic manner. [Cells] Full Article Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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SCIENCE NEWSTRACON Pharmaceuticals Announces TRC105, TRC253 and TRC102 Data Presentations TRACON Pharmaceuticals announced that preclinical data from TRC105 and TRC253, as well as Phase II clinical data from TRC102, will be presented. [Press release from TRACON Pharmaceuticals discussing research presented at the American Association for Cancer Research (AACR) Annual Meeting, Atlanta] Press Release | |
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INDUSTRY NEWSHutchison China MediTech Limited (Chi-Med) has initiated a registration-enabling Phase IIb/III study comparing surufatinib with capecitabine in patients with advanced biliary tract cancer whose disease progressed on first-line chemotherapy. [Hutchison China MediTech Limited] Press Release Herantis Pharma Plc announced the expansion of its Phase II AdeLE clinical trial in Sweden to include the Karolinska University Hospital in Stockholm, and the Uppsala University Hospital. The AdeLE study will also continue to recruit patients at three university hospitals in Finland. [Herantis Pharma Plc] Press Release Apollomics, Inc. announced positive data for the company’s multi-kinase inhibitor, APL-102, as both a single agent and in combination with an anti-PD-1 antibody in multiple preclinical studies. [Apollomics, Inc.] Press Release Outlook Therapeutics Announces FDA Acceptance of IND for ONS-5010 Outlook Therapeutics, Inc. announced the FDA acceptance and activation of the Investigational New Drug (IND) application for the company’s lead product candidate, ONS-5010, an innovative monoclonal antibody therapeutic product candidate being developed for wet age related macular degeneration, diabetic macular edema and branch retinal vein occlusion. [Outlook Therapeutics, Inc.] Press Release | |
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POLICY NEWSNational Academy of Sciences Will Vote on Ejecting Sexual Harassers The U.S. National Academy of Sciences in Washington, D.C., will ask its members this month to change the organization’s bylaws to allow proven sexual harassers and those guilty of other misconduct to be ejected from their ranks. That’s a first for the prestigious organization that advises the U.S. government on scientific issues: Its members, who are voted in by other members, have always been elected for life. [ScienceInsider] Editorial What Thailand’s Long-Awaited Election Could Mean for Science Thailand is bracing for the results of its first election since a military junta took charge in a 2014 coup. Scientists, like many other people in Thailand, want a more democratic country. But whether a pro-democracy party or a military-backed one ends up in charge, science is likely to prosper as a result of ongoing reforms put in place by the junta that are likely to continue under either government. [Nature News] Editorial
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EVENTSNEW Cell Symposia: Regulatory RNAs Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESPhD Position – Vascular Biology (Uppsala University) Postdoctoral Research Scientist – Regulatory Pathways During Development (Oxford University) Postdoctoral Position – Vascular Biology (Albert Einstein College of Medicine) Postdoctoral Research Assistant – Cancer & Vascular Biology (University of Oxford) Faculty Position – Bioengineering (University of Pittsburgh) Vascular Biologist – RNA Therapeutics (Guide Therapeutics) Postdoctoral Fellow – Vascular Biology (Stanford School of Medicine) Tier 2 Canada Research Chair – Cardiovascular/Vascular Health (University of Ottawa) Faculty Position – Clinical & Experimental Therapeutics (Augusta University) Assistant/Associate Adjunct Professor – Cardiovascular Medicine (UC Davis) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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