Endothelial Cell News 4.15 April 29, 2019 | |
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TOP STORYSR-B1 Drives Endothelial Cell LDL Transcytosis via DOCK4 to Promote Atherosclerosis Researchers showed in mice that scavenger receptor class B type 1 (SR-B1) in endothelial cells mediated the delivery of low-density lipoprotein (LDL) into arteries and its accumulation by artery wall macrophages, thereby promoting atherosclerosis. [Nature] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Blocking primary cilia formation or function by genetic or chemical manipulations impaired hematopoietic stem and progenitor cell (HSPC) development. Mechanistically, scientists uncovered that the primary cilia in endothelial cells transduced Notch signal to the earliest hemogenic endothelium for proper HSPC specification during embryogenesis. [Nat Commun] Full Article Microsomal prostaglandin E (PGE) synthase-1 (mPges-1) deletion depressed arteriolar dilatory response to ischemia/reperfusion in vivo and to acetylcholine ex vivo, and enhanced leukocyte-endothelial cell interaction, which was mediated via PGE receptor-4 (EP4). [Nat Commun] Full Article In zebrafish and human endothelial cells, Nova2 selectively regulated pre-mRNA splicing for components of signaling pathways and phosphoproteins. Nova2-deficient endothelial cells displayed increased Mapk/Erk signaling, and Prox1 expression was dynamically controlled by Erk signaling. [Dev Cell] Abstract | Graphical Abstract In cultured endothelial cells, narciclasine inhibited the expression of cell adhesion molecules intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin and blocked crucial steps of the NF-κB activation cascade: NF-κB promotor activity, p65 nuclear translocation, inhibitor of κB α (IκBα) phosphorylation and degradation, and IκBα kinase β and TGF-β-activated kinase 1 phosphorylation. [FASEB J] Abstract Researchers investigated the roles and the molecular interaction of SIRT1 and TLR2 in regulating monocyte adhesion to the vascular endothelium. In vitro, both Mac-1 expression and the endothelial adhesion of THP-1 cells stimulated with Pam3CSK4, a TLR2 ligand, were markedly increased in association with a decreased expression of SIRT1. [Exp Mol Med] Full Article EphrinB2/EphB4 Signaling Regulates DPSCs to Induce Sprouting Angiogenesis of Endothelial Cells Using a 3-D fibrin gel model, scientists investigated whether EphrinB2/EphB4 signaling in dental pulp stem cells (DPSCs) played a role in supporting vascular morphogenesis mediated by endothelial cells, together with the underlying mechanism involved. [J Dent Res] Abstract Investigators evaluated the effect of platelets on functional properties of late endothelial progenitor cells (EPCs), in direct co-culture conditions, and investigated the involved mediators, in experimental induced atherosclerosis. Late EPCs obtained from two animal groups, hypertensive-hyperlipidemic and control hamsters, were co-incubated with or without platelets isolated from both groups. [Front Pharmacol] Full Article Researchers evaluated the effects of metformin, and its sulfenamide and sulfonamide derivatives on selected markers of endothelial function and blood coagulation. The integrity of endothelial cells was examined using the real-time cell electric impedance system. [Sci Rep] Full Article Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSAlternative Splicing in Angiogenesis The authors focus on the alternative spliced isoforms of key genes that are involved in the angiogenesis process; VEGF-A, VEGFR1, VEGFR2, NRP-1, FGFRs, Vasohibin-1, Vasohibin-2, HIF-1α, Angiopoietin-1 and Angiopoietin-2. [Int J Mol Sci] Full Article Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSHerantis Pharma Plc announced the topline results from the 12-month follow-up review of the Phase I Lymfactin® trial in breast cancer-associated lymphedema. Lymfactin®, the novel gene therapy of Herantis that aims to repair the damaged lymphatic system in breast-cancer associated lymphedema patients, is currently in a multi-center Phase II clinical study AdeLE in Sweden and Finland. [Herantis Pharma Plc] Press Release MGH Receives $200 Million to Advance Research into Complex Diseases Massachusetts General Hospital (MGH) announced it has received the largest gift in the hospital’s history – $200 million – to endow the Ragon Institute of MGH, MIT and Harvard. [Massachusetts General Hospital] Press Release National Institutes of Health Awards $2.7M to Leadership Alliance The National Institutes of Health has awarded a $2.7 million grant to the Leadership Alliance, a Brown University-based consortium of 35 leading research and teaching institutions that works to train, mentor and inspire students from diverse backgrounds to pursue research careers. [Brown University] Press Release | |
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POLICY NEWSUS Universities Reassess Collaborations with Foreign Scientists in Wake of NIH Letters Kuspa’s attempt to stay ahead of the US National Institutes of Health (NIH) came to naught. A few months into the audit, Baylor College of Medicine received letters from the NIH asking about four scientists it believed had violated the agency’s rule requiring them to disclose all foreign ties relating to their research. [ScienceInsider] Editorial Elsevier and Norway Agree on New Open-Access Deal After unsuccessful negotiations between a coalition of Norwegian organizations and the academic publisher Elsevier culminated in cancelled subscriptions earlier this year, the two have successfully established a new nationwide licensing agreement. [The Scientist] Editorial Fearing No-Deal Brexit, European Funder Orders UK Researchers to Transfer Grants The prospect of Brexit, the United Kingdom’s departure from the European Union, has loomed long and large over researchers, but the effects on funding, so far, have been speculative. Now, a European funding agency has made a pre-emptive strike in advance of Brexit, changing a policy that directly impacts grants in the United Kingdom. [ScienceInsider] Editorial
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EVENTSNEW Keystone Symposia: Tumor Metabolism Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Researchers – Vascular Biology in Metabolic Disorders (Karolinska Institutet) Postdoctoral Position – The Vascular System in the Brain (Uppsala University) Research Associate – Cell Plasticity & Heterogeneity in Vascular Biology (University of Cambridge) Postdoctoral Position – Angiogenesis & Vascular Biology (Johns Hopkins University) Postdoctoral Position – Vascular Tissue Engineering (BioTis) Postdoctoral Position – Vascular Development (University of Massachusetts Medical School) Postdoctoral Position – Vascular Biology (Albert Einstein College of Medicine) Assistant/Associate Adjunct Professor – Cardiovascular Medicine (UC Davis) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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