Endothelial Cell News Volume 4.24 | Jul 15 2019

TOP STORY

Rapid Fabrication of Reinforced and Cell-Laden Vascular Grafts Structurally Inspired by Human Coronary Arteries

A new automated technology was presented that combined a dip-spinning methodology for depositioning concentric cell-laden hydrogel layers with an adapted solution blow spinning device for intercalated placement of aligned reinforcement nanofibres. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

Identifying and Targeting Angiogenesis-Related MicroRNAs in Ovarian Cancer

MicroRNA profiling of patient data sets, along with in vitro and in vivo experiments, revealed that miR-0204-5p could promote angiogenesis in ovarian tumors through THBS1. By binding with scavenger receptor class B type 1, reconstituted high-density lipoprotein-nanoparticles were effective in delivering miR-204-5p inhibitor to tumor sites to suppress tumor growth. [Oncogene] Abstract

KHDRBS3 Regulates the Permeability of Blood-Tumor Barrier via cDENND4C/miR-577 Axis

RNA-binding protein KH RNA-binding domain containing, signal transduction associated 3 (KHDRBS3) and circular RNA DENND4C (cDENND4C) were enriched in GECs. KHDRBS3 bound to cDENND4C and increased its stability. The knockdown of cDENND4C increased the permeability of BTB via downregulating the expressions of tight junction-related proteins. [Cell Death Dis] Full Article

Transient Receptor Potential Channel Expression Signatures in Tumor-Derived Endothelial Cells: Functional Roles in Prostate Cancer Angiogenesis

Researchers profiled by qPCR the expression of all transient receptor potential channels in human prostate tumor-derived endothelial cells (TECs) in comparison with TECs from breast and renal tumors. They further functionally characterized the role of the ‘prostate-associated’ channels in proliferation, sprout formation and elongation, directed motility guiding, as well as in vitro and in vivo morphogenesis and angiogenesis. [Cancers] Full Article

Osteosarcoma Cell-Derived Exosomes Affect Tumor Microenvironment by Specific Packaging of MicroRNAs

Exosomes potentiated tube formation of endothelial cells and increased angiogenic markers expression. Scientists therefore investigated the miRNA cargo from exosomes and their parental cells by performing small RNA sequencing through NGS Illumina platform. [Carcinogenesis] Abstract

Differences in Placental Capillary Shear Stress in Fetal Growth Restriction May Affect Endothelial Cell Function and Vascular Network Formation

Endothelial cells cultured under predicted fetal growth restriction shear stresses migrated significantly slower and with greater persistence than in shear stresses predicted in normal placentae. These cell behaviors suggested a dominance of vessel elongation over branching. [Sci Rep] Full Article

MicroRNA410 Inhibits Pulmonary Vascular Remodeling via Regulation of Nicotinamide Phosphoribosyltransferase

Overexpression of miR410 in human pulmonary artery endothelial cells (hPAECs) inhibited basal and VEGF-induced proliferation, migration and promoted apoptosis of hPAECs, while miR410 inhibition via antagomirs had the opposite effect. Administration of miR410 mimics in vivo attenuated induction of nicotinamide phosphoribosyltransferase in PAECs and prevented the development of hypoxia-induced pulmonary hypertension in mice. [Sci Rep] Full Article

Erg Mediates Downregulation of Claudin-5 in the Brain Endothelium of a Murine Experimental Model of Cerebral Malaria

Researchers established a murine experimental cerebral malaria (ECM) model and an in vitro model by treating murine brain endothelial cells with plasma from ECM mice. Expression of claudin-5 and the ETS transcription factor Erg were reduced in the brain endothelium of ECM mice. [FEBS Lett] Abstract

SIRT6 Protects Vascular Endothelial Cells from Angiotensin II-Induced Apoptosis and Oxidative Stress by Promoting the Activation of Nrf2/ARE Signaling

Investigators showed that sirtuin6 (SIRT6) expression was decreased in vascular endothelial cells exposed to angiotensin II. This was accompanied by decreased cell viabilities as well as increased apoptosis and the production of reactive oxygen species. [Eur J Pharmacol] Abstract | Graphical Abstract

Periodontitis-Induced Systemic Inflammation Exacerbates Atherosclerosis Partly via Endothelial-Mesenchymal Transition in Mice

In vitro, Porphyromonas gingivalis lipopolysaccharide injection enhanced the secretion of pro-inflammatory cytokines from macrophages and increased the adhesion of monocytes to endothelial cells by upregulating the expression of adhesion molecules from endothelial cells. Moreover, secretory proteins, such as TNF-α, from macrophages induced endothelial-mesenchymal transitions of the endothelial cells. [Int J Oral Sci] Full Article

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Lymphatic and Blood Systems: Identical or Fraternal Twins?

The likeliness between the two vascular systems may lead to a simplistic view of lymphatics and a direct transcription of what is known for the blood system to the lymphatic one, thereby neglecting the lymphatic specificities. The authors aim to clarify the main differences between the two vascular systems focusing on recently discovered lymphatic features. [Int J Biochem Cell Biol] Abstract

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Mereo BioPharma Announces Successful Type B Meeting with US FDA and Outlines Accelerated Approval Pathway for Navicixizumab in Advanced Ovarian Cancer

Mereo BioPharma Group plc announced that it has held a successful Type B meeting with the FDA regarding a potential pathway for accelerated approval for navicixizumab for the treatment of patients with advanced ovarian cancer. [Mereo BioPharma Group plc] Press Release

St. Jude Physician-Scientist Receives AACR Award

The American Association for Cancer Research has named Esther Obeng, MD, PhD, of St. Jude Children’s Research Hospital recipient of the 2019 Gertrude B. Elion Cancer Research Award. The award supports researchers early in their careers to support basic, translational or clinical research focused on the cause, diagnosis, treatment or prevention of cancer. [The American Association for Cancer Research (Healio)] Press Release

University of California Loses Access to New Journal Articles Published by Elsevier after Research Access Fight

Researchers in the University of California system lost subscription access to the major publisher Elsevier, the result of a closely watched fight between the two parties over how academic research should get read and paid for. [STAT News] Editorial

Sweden Passes Law For National Research Misconduct Agency

After several high-profile cases, the country’s government is creating a board to oversee and investigate all serious allegations of scientific misconduct. [The Scientist] Editorial

As Visa Difficulties Persist, Scientists Push for Change

Individual researchers and science societies are finding solutions so colleagues around the globe can attend conferences, from remote presentations to relocating conferences. [The Scientist] Editorial

NEW Endothelial Cell Phenotypes in Health and Disease
June 28-July 3, 2020
Barcelona, Spain

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NEW Research Assistant – Genitourinary Medical Oncology (MD Anderson Cancer Center)

Research Technician – 3D Vascularized In Vitro Tissue Development (European Molecular Biology Laboratory)

Group Leader – Vascular Biology (Ludwig-Maximilians-University)

Postdoctoral Researcher – Vascular Biology (Karolinska Institutet)

Postdoctoral Fellow – Endothelial Cell Ion Channels (The University of Tennessee Health Science Center)

Postdoctoral Position – Vascular Research (University of Illinois-Chicago)

Faculty Positions – Cardiovascular Biomedical Research (Virginia Tech)

Postdoctoral Fellow – Endothelial Dysfunction in Inflammatory Disease (Seattle Children’s Hospital)

Assistant/Associate Professor – Vascular Physiology & Disease (Stanford Medicine)

Postdoctoral Fellowship – Neurovascular Imaging Research (University of Nevada)

Postdoctoral Fellow – Cardiovascular Diseases (Rutgers University)

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