Endothelial Cell News Volume 4.25 | Jul 22 2019

TOP STORY

Endothelial Foxp1 Suppresses Atherosclerosis via Modulation of Nlrp3 Inflammasome Activation

To assess the importance of forkhead box P transcription factor 1 (Foxp1) in atherosclerosis, Foxp1 expression was analyzed in human coronary artery and mouse artery and scientists observed significant down-regulation of Foxp1 in atherosclerotic and athero-susceptible endothelium. [Circ Res] Abstract

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Weibel-Palade Bodies Orchestrate Pericytes during Angiogenesis

Weibel-palade bodies (WPB) density in endothelial cells decreased at the angiogenic front of retinal vascular network during development and reneovascularization compared with stable vessels. In vitro, VEGF induced a VEGFR-2-dependent exocytosis of WPBs that contained Ang-2 and consequently the secretion of von Willebrand factor and Ang-2. [Arterioscler Thromb Vasc Biol] Abstract

HMGA1 Promotes Breast Cancer Angiogenesis Supporting the Stability, Nuclear Localization and Transcriptional Activity of FOXM1

The impact on angiogenesis was assessed in vitro, evaluating the tube formation ability of endothelial cells exposed to the conditioned medium of MDA-MB-231 cells silenced for HMGA1 and FOXM1 and in vivo by injecting MDA-MB-231 cells, silenced for the two factors, in zebrafish larvae. [J Exp Clin Cancer Res] Full Article

Severe Heterotopic Ossification in the Skeletal Muscle and Endothelial Cells Recruitment to Chondrogenesis Are Enhanced by Monocyte/Macrophage Depletion

Researchers investigated in vivo whether cells of endothelial origin phenotypically changed upon heterotopic ossification induction and whether infiltration of innate immunity cells influenced their commitment and altered ectopic bone formation. [Front Immunol] Full Article

Endothelial Progenitor Cell-Derived Exosomes Facilitate Vascular Endothelial Cell Repair through Shuttling miR-21-5p to Modulate Thrombospondin-1 Expression

Integrative analyses of miRNA-mRNA interactions revealed that miR-21-5p was highly enriched in endothelial progenitor cell-exosomes and specifically suppressed the expression of an angiogenesis inhibitor thrombospondin-1 in recipient endothelial cells. [Clin Sci (Lond)] Abstract

YAP1 Is Required for the Angiogenesis in Retinal Microvascular Endothelial Cells via the Inhibition of MALAT1-Mediated miR-200b-3p in High Glucose-Induced Diabetic Retinopathy

Yes-associated protein 1 (YAP1) was observed to be highly expressed in retinas from abetic retinopathy mice, which promoted the cellular processes of retinal microvascular endothelial cells through upregulating metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) expression. [J Cell Physiol] Abstract

Endothelial Tip Cells In Vitro Are Less Glycolytic and Have a More Flexible Response to Metabolic Stress than Non-Tip Cells

The authors showed that both tip cells and non-tip cells used glycolysis as well as mitochondrial respiration for energy production. However, glycolysis was significantly lower in tip cells than in non-tip cells. Additionally, tip cells had a higher capacity to respond to metabolic stress. [Sci Rep] Full Article

Extracellular Vesicles from T Cells Overexpress miR-146b-5p in HIV-1 Infection and Repress Endothelial Activation

Investigators demonstrated that extracellular vesicles from T cell line overexpressing miR-146b-5p mimics protected their miRNA cargo from RNase degradation, transfered miR-146b-5p mimics into endothelial cells and reduced endothelial inflammatory responses in vitro and in vivo in the lungs of mice through the downregulation of nuclear factor-κB-responsive molecules. [Sci Rep] Full Article

Kynurenic Acid Attenuates Pro-Inflammatory Reactions in Lipopolysaccharide-Stimulated Endothelial Cells through the PPARδ/HO-1-Dependent Pathway

Kynurenic acid enhanced peroxisome proliferator-activated receptor delta (PPARδ) expression in HUVECs and THP-1-cells and suppressed lipopolysaccharide-induced atherosclerotic responses through PPARδ-mediated signaling. [Mol Cell Endocrinol] Abstract | Graphical Abstract

ZYZ-803, a Novel Hydrogen Sulfide-Nitric Oxide Conjugated Donor, Promotes Angiogenesis via Cross-Talk between STAT3 and CaMKII

Treatment with ZYZ-803 significantly increased the phosphorylation of STAT3 and CaMKII in HUVECs; these two effects had a similar time course. Pretreatment with WP1066 or KN93 blocked ZYZ-803-induced STAT3/CAMKII activation and significantly suppressed the proliferation and migration of HUVECs. [Acta Pharmacol Sin] Abstract

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Tumor Vasculatures: A New Target for Cancer Immunotherapy

Investigators highlight current evidence supporting immune system-tumor vasculature crosstalk and outline how this relationship can provide new rationales for developing more effective combination immunotherapy strategies for treating human cancers. [Trends Pharmacol Sci] Abstract

Improving CNS Delivery to Brain Metastases by Blood-Tumor Barrier Disruption

The authors review blood-brain barrier (BBB) physiology and blood-tumor barrier (BTB) pathophysiology. Additionally, they review the limitations of routinely practiced therapies and three current methods being explored for BBB/BTB disruption for improved delivery of chemotherapy to brain tumors. [Trends Cancer] Abstract

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Outlook Therapeutics Doses First Patient in the Second Phase III Clinical Trial for ONS-5010 in Wet AMD

Outlook Therapeutics, Inc. announced that it has dosed the first patient in the ONS-5010-002 Phase III clinical trial. ONS-5010-002 is the second of the company’s two required adequate and well controlled Phase III clinical trials evaluating ONS-5010 against ranibizumab for wet age related macular degeneration (AMD). [Outlook Therapeutics, Inc.] Press Release

FDA Accepts File and Accelerates Review of Novartis Sickle Cell Disease Medicine Crizanlizumab (SEG101)

Novartis announced the FDA accepted the company’s Biologics License Application and has granted Priority Review for its investigational sickle cell medicine crizanlizumab. If FDA-approved, crizanlizumab is expected to represent the first monoclonal antibody targeting the P-selectin mediated multi-cellular adhesion in sickle cell disease. [Novartis AG] Press Release

Fight for Coveted CRISPR Patents Gets Knottier, as MilliporeSigma Makes New Claims

After nearly seven years of failing to win fundamental patents on the genome-editing technology CRISPR, a unit of one of the world’s largest life sciences companies has thrown a Hail Mary: MilliporeSigma petitioned the US Patent and Trademark office to open an interference proceeding between CRISPR-Cas9 patents that it applied for way back in 2012 and patents that the University of California has applied for or been awarded. [STAT News] Editorial

Mystery Surrounds Ouster of Chinese Researchers from Canadian Laboratory

Canadian researchers are reacting with puzzlement to the news that a “policy breach” has caused the nation’s only high-containment disease laboratory to bar a prominent Chinese Canadian virologist, her biologist husband, and a number of students from the facility. [ScienceMagazine] Editorial

NEW Stem Cells UK
October 1, 2019
London, United Kingdom

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NEW Postdoctoral Fellowship – Cancer Therapeutics & Angiogenesis (Boston Children’s Hospital)

Research Assistant – Genitourinary Medical Oncology (MD Anderson Cancer Center)

Research Technician – 3D Vascularized In Vitro Tissue Development (European Molecular Biology Laboratory)

Group Leader – Vascular Biology (Ludwig-Maximilians-University)

Postdoctoral Researcher – Vascular Biology (Karolinska Institutet)

Postdoctoral Fellow – Endothelial Cell Ion Channels (The University of Tennessee Health Science Center)

Postdoctoral Position – Vascular Research (University of Illinois-Chicago)

Faculty Positions – Cardiovascular Biomedical Research (Virginia Tech)

Postdoctoral Fellow – Endothelial Dysfunction in Inflammatory Disease (Seattle Children’s Hospital)

Assistant/Associate Professor – Vascular Physiology & Disease (Stanford Medicine)

Postdoctoral Fellowship – Neurovascular Imaging Research (University of Nevada)

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