Endothelial Cell News 4.31 September 16, 2019 | |
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TOP STORYAn in vitro study demonstrated that compared with the random drug-loaded or other control groups, the aligned tazarotene-loaded membranes could stimulate the proliferation, migration, angiogenesis, VEGF secreting and its gene expression of HUVECs. [ACS Appl Mater Interfaces] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)In vitro, scientists identified a direct action of fibroblast growth factor (FGF) 21 on endothelial cells of the aorta, in which it bound to FGF receptors to alleviate impaired endothelial function challenged with high glucose. [Cell Death Dis] Full Article Icariin significantly promoted bone microvascular endothelial cells migration, tube formation, the angiogenesis-related cytokines expression and the activation of Akt. [J Cell Mol Med] Full Article Ultrastructural injury to podocytes and glomerular endothelium was prominent in hypertensive TTRhRen EP1−/− mice; including widened subendothelial space, subendothelial lucent zones and focal lifting of endothelium from basement membrane, with focal subendothelial cell debris. [Lab Invest] Abstract Blocking intercellular adhesion molecule-1 with a neutralizing antibody significantly attenuated angiotensin II-induced arterial hypertension, vascular hypertrophy, fibrosis, macrophage infiltration, and reactive oxygen species production and improved vascular relaxation. [Lab Invest] Abstract To elucidate the role of intercellular adhesion molecule-1 (ICAM-1) on the crosstalk between tumor and primary liver sinusoidal endothelial cells and hepatic stellate cells, implicated in tumor adhesion and angiogenesis, investigators performed in vitro cocultures and an in vivo model of liver metastasis of colorectal cancer. [Sci Rep] Full Article Interplay of Plasmodium falciparum and Thrombin in Brain Endothelial Barrier Disruption Researchers examined how mature-stage P. falciparum infected erythrocytes interacted with tumor necrosis factor α and thrombin in the activation and permeability of primary human brain microvascular endothelial cell monolayers. [Sci Rep] Full Article Scientists investigated the toxicity of PEGylated gold nanorods to HUVECs, a commonly used in vitro model for human endothelium. [Toxicol Appl Pharmacol] Abstract Antiangiogenesis Effect of Timosaponin AIII on HUVECs In Vitro and Zebrafish Embryos In Vivo The authors demonstrated that timosaponin AIII treatment significantly suppressed the expression of VEGF receptor and the phosphorylation of Akt, MEK1/2, and ERK1/2 in HUVECs. [Acta Pharmacol Sin] Abstract Growth hormone-releasing hormone enhanced the proliferation, migration, and angiogenesis capacity of peripheral blood-endothelial progenitor cells and reduced apoptosis under H2O2 stimulation. [J Endocrinol Invest] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSInvestigators focused on current preclinical studies examining how to prevent ischemia-induced endothelial dysfunction. [Arterioscler Thromb Vasc Biol] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSAVEO Oncology announced results from the second prespecified analysis of overall survival in the TIVO-3 trial. TIVO-3 is the company’s Phase III randomized, controlled, multi-center, open-label study to compare tivozanib to sorafenib in 350 subjects with highly refractory metastatic renal cell carcinoma. [AVEO Oncology] Press Release Cook Regentec announced enrollment of the first patient in an international clinical trial evaluating the HemaTrate® Blood Filtration System to treat patients with critical limb ischemia due to peripheral arterial disease. [Cook Regentec (Business Wire, Inc.)] Press Release | |
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POLICY NEWSScience under Maximum Pressure in Iran From travel restrictions and publishing bans to currency collapse, the restoration of US sanctions has left researchers in Iran reeling. [The Scientist] Editorial EU Research Commissioner Named, but Lacks ‘Research’ in Her Title Mariya Gabriel, a conservative politician from Bulgaria, is slated to become the next European research chief- although her job title, unlike that of her predecessors, doesn’t include the words “research” or “science”. [ScienceInsider] Editorial
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EVENTSNEW NF-kB, JAK-STAT & MAPK in Health, Disease & Therapy Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Liver Macrophage Niche (Flanders Institute for Biotechnology) NEW Postdoctoral Position – Alzheimer’s disease (Icahn School of Medicine) NEW Postdoctoral Position – Vascular Biology (New York University Winthrop Hospital) Scientific Communications Coordinator (STEMCELL Technologies Inc.) Science Manager – Vascular Biology (Max Delbrück Center for Molecular Medicine) PhD and Postdoctoral Positions – Neurovascular Biology (Université Libre de Bruxelles) Research Fellow – Vascular Stem Cell Biology (Queen’s University Belfast) Faculty Positions – Basic and Translational Cardiovascular Sciences (New York University) Postdoctoral Fellow – Cardiovascular Physiology (University of California, San Diego) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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