Endothelial Cell News Volume 4.32 | Sep 23 2019

TOP STORY

Lung Endothelial Cell Antigen Cross-Presentation to CD8⁺ T Cells Drives Malaria-Associated Lung Injury

Pulmonary vascular damage in acute lung injury was a consequence of IFNγ-activated lung endothelial cells capturing, processing, and cross-presenting malaria parasite antigen to specific CD8⁺ T cells induced during infection. [Nat Commun] Full Article

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Circular RNA CircFndc3b Modulates Cardiac Repair after Myocardial Infarction via FUS/VEGF-A Axis

Overexpression of circFndc3b in cardiac endothelial cells increased VEGF-A expression, enhanced their angiogenic activity and reduced cardiomyocyte and endothelial cell apoptosis. [Nat Commun] Full Article

Endothelial β-Catenin Signaling Supports Postnatal Brain and Retinal Angiogenesis by Promoting Sprouting, Tip Cell Formation, and VEGFR 2 Expression

Using genetically modified mouse models, the authors showed that impaired endothelial β-catenin signaling caused hypovascularization of the postnatal retina and brain because of deficient endothelial cell proliferation and sprouting. [Arterioscler Thromb Vasc Biol] Abstract

Self-Assembling In Situ Gel Based on Lyotropic Liquid Crystals Containing VEGF for Tissue Regeneration

In vitro, VEGF-lyotropic liquid crystals considerably promoted the proliferation, migration, and tube formation of HUVECs as compared to free VEGF. [Acta Biomater] Full Article | Graphical Abstract

The 5-Hydroxytryptamine Receptor 1F Stimulates Mitochondrial Biogenesis and Angiogenesis in Endothelial Cells

Treatment of human glomerular endothelial cells with LY344864 or lasmiditan enhanced endothelial branching morphogenesis and migration, indicating a role for 5-HT_1F receptor stimulation in angiogenic pathways. [Biochem Pharmacol] Abstract | Graphical Abstract

Signaling Pathways in Cytoskeletal Responses to Plasma Membrane Depolarization in Corneal Endothelial Cells

Researchers investigated the signaling pathways involved in the response of bovine corneal endothelial cells to plasma membrane potential depolarization. [J Cell Physiol] Abstract

Development of Immortalized Human Tumor Endothelial Cells from Renal Cancer

Scientists established immortalized human tumor endothelial cells and their normal counterparts by infection with lentivirus producing simian virus 40 large T antigen and human telomerase reverse transcriptase to overcome the replication barriers. [Int J Mol Sci] Full Article

Endothelial Progenitor Cells Attenuate Ventilator-Induced Lung Injury with Large-Volume Ventilation

The authors investigated the effect of endothelial progenitor cell (EPC) transplantation on ventilator-induced lung injury (VILI). Wistar rats were divided into three groups: sham, VILI model induced by tidal volume ventilation, and VILI plus EPC transplantation groups. [Cell Transplant] Full Article

Progenitor-Derived Human Endothelial Cells Evade Alloimmunity by CRISPR/Cas9-Mediated Complete Ablation of MHC Expression

Investigators report that CRISPR/Cas9-mediated dual ablation of β2-microglobulin and CIITA in human endothelial colony forming cell-derived endothelial cells (ECs) eliminated both class I and II MHC expression while retaining EC functions and vasculogenic potential. [JCI Insight] Abstract | Full Article

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Trends and Challenges in Tumor Anti-Angiogenic Therapies

The authors enumerate some of the current approaches and possible future directions of treating solid tumors by targeting neovascularization. [Cells] Full Article

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BGN Technologies Licenses Polymer for Targeted Cancer Therapy to Vaxil Bio

BGN Technologies announced that it has entered into an exclusive worldwide license agreement with Vaxil Bio for the development and commercialization of targeted cancer therapy. [BGN Technologies (PR Newswire Association LLC.)] Press Release

Graybug Vision Initiates Clinical Trial in Macular Edema Secondary to Diabetic Macular Edema or Retinal Vein Occlusion

Graybug Vision, Inc. announced the initiation of its Phase IIa study with GB-102 in patients with macular edema (ME) secondary to diabetic ME or retinal vein occlusion. [Graybug Vision, Inc.] Press Release

Kashmir’s Communication Blackout Is a ‘Devastating Blow’ for Academics, Researchers Say

Six professors from India’s top science institutions have appealed to the government to lift the blockade of academic and research institutions in Indian-controlled Kashmir. The blockade has been a “devastating blow,” the six write in an open letter published September 18^th. [ScienceInsider] Editorial

Senate Bill Would Give NIH $3 Billion in 2020, or 7.7% Boost

A Senate spending panel today released a draft 2020 spending bill containing a hefty $3 billion increase for the National Institutes of Health (NIH) that would bring the agency’s total budget to $42.1 billion. That 7.7% boost is $1 billion more than a House of Representatives committee approved in its version of the bill in April, and would amount to a 40% increase in NIH’s budget over the past five years. [ScienceInsider] Editorial

NEW Hypoxia: Molecules, Mechanisms and Disease
January 19-23, 2020
Keystone, Colorado, United States

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NEW Full Professorship – Translational Vascular Biomedicine (Charité – University Medicine Berlin)

NEW Postdoctoral Fellow – Ophthalmology (The University of Tennessee Health Science Center)

NEW Postdoctoral Fellow and Graduate Student – Cardiovascular Sciences (University of Calgary)

NEW Research Associate – Vascular and Skeletal Biology (Imperial College London)

Postdoctoral Position – Liver Macrophage Niche (Flanders Institute for Biotechnology)

Postdoctoral Position – Alzheimer’s disease (Icahn School of Medicine)

Postdoctoral Position – Vascular Biology (New York University Winthrop Hospital)

PhD and Postdoctoral Positions – Neurovascular Biology (Université Libre de Bruxelles)

Postdoctoral Position – Endothelial Cell Research (The University of Tennessee Health Science Center)

Faculty Positions – Basic and Translational Cardiovascular Sciences (New York University)

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