Endothelial Cell News Volume 4.34 | Oct 7 2019

TOP STORY

Engineering of Human Brain Organoids with a Functional Vascular-Like System

Researchers found that vascularized human cortical organoids acquired several blood-brain barrier characteristics, including an increase in the expression of tight junctions, nutrient transporters and trans-endothelial electrical resistance. [Nat Methods] Abstract

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Conjugated Polymers Optically Regulate the Fate of Endothelial Colony-Forming Cells

Scientists proposed a innovative strategy to gain optical control of endothelial colony-forming cell fate, which represented the only known truly endothelial precursor showing robust in vitro proliferation and overwhelming vessel formation in vivo. [Sci Adv] Full Article

A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization

The authors showed that the genetic loss of Id1/Id3 reduced ocular neovascularization in mouse models of wet age-related macular degeneration and retinopathy of prematurity. [Cell Rep] Full Article | Graphical Abstract

Endothelial PKA Activity Regulates Angiogenesis by Limiting Autophagy through Phosphorylation of ATG16L1

Investigators showed that endothelial protein kinase A (PKA) activity mediates a critical switch from active sprouting to quiescence in part through phosphorylation of ATG16L1, which in turn reduced endothelial autophagy. [eLife] Full Article

High-Endothelial Cell-Derived S1P Regulates Dendritic Cell Localization and Vascular Integrity in the Lymph Node

Researchers revealed that endothelial cell-derived sphingosine-1-phosphate (S1P) warranted high-endothelial venule (HEV)-integrity through autocrine control of S1PR1-Gi signaling, and facilitated concomitant HEV-dendritic cell interactions. [eLife] Full Article

Regulatory T Cells Promote Corneal Endothelial Cell Survival following Transplantation via Interleukin-10

Using two well-established models of corneal transplantation, investigators showed that regulatory T cells (Tregs) derived from low-risk graft recipients had a superior capacity in protecting corneal endothelial cells against effector T cell-mediated and IFN-γ and TNF-α-induced cell death compared to Tregs derived from high-risk hosts. [Am J Transplant] Abstract

Simvastatin Preparations Promote PDGF-BB Secretion to Repair LPS-Induced Endothelial Injury through the PDGFRβ/PI3K/Akt/IQGAP1 Signaling Pathway

The authors showed that simvastatin (SV)/SV-nanoparticles (NPs) promoted the migration and decreased the permeability of HUVECs treated with lipopolysaccharide (LPS), and the efficacy of the SV-NPs exceeded that of SV significantly. [J Cell Mol Med] Full Article

Enhanced Endothelial Motility and Multicellular Sprouting Is Mediated by the Scaffold Protein TKS4

Scientists demonstrated that the absence of Tks4 in endothelial cells lead to impaired extracellular matrix (ECM) cleavage and decreased motility within a 3D ECM environment. [Sci Rep] Full Article

Loss of HMBOX1 Promotes LPS-Induced Apoptosis and Inhibits LPS-Induced Autophagy of Vascular Endothelial Cells in Mouse

Loss of homeobox containing 1 (HMBOX1) promoted apoptosis and inhibited autophagy of aortic endothelial cells under lipopolysaccharide (LPS) stimulation in mouse. [Apoptosis] Abstract

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Role of Angiocrine Signals in Bone Development, Homeostasis and Disease

Distinct blood vessel subtypes with differential angiocrine profiles differentially regulate osteogenesis and hematopoiesis, and drive disease states in the skeletal system. The authors provide an overview of the role of angiocrine signals in bone during homeostasis and disease. [Open Biol] Full Article

Visit our reviews page to see a complete list of reviews in the endothelial cell research field.

Graybug Vision Initiates Phase IIb (ALTISSIMO) Clinical Trial of GB-102 in Patients with Wet Age-Related Macular Degeneration

Graybug Vision, Inc. announced the initiation of its Phase IIb study with GB-102 in patients with wet age-related macular degeneration. [Graybug Vision, Inc.] Press Release

Mereo BioPharma Receives FDA Fast Track Designation for Navicixizumab for the Treatment of Heavily Pretreated Ovarian Cancer

Mereo BioPharma Group plc announced that the FDA has granted Fast Track designation to navicixizumab for the treatment of high grade ovarian, primary peritoneal or fallopian tube cancer in patients who have received at least three prior therapies and/or prior bevacizumab. [Mereo BioPharma Group plc] Press Release

Biologists Who Decoded How Cells Sense Oxygen Win Medicine Nobel

A trio of researchers has won the 2019 Nobel Prize in Physiology or Medicine for describing how cells sense and respond to changing oxygen levels by switching genes on and off — a discovery that has been key in understanding human diseases such as cancer and anemia. [Nature News] Editorial

Split Decisions: How Brexit Has Taken a Toll on Five Researchers

On 23 June 2016, 34 million U.K. citizens took to the polls to vote on a simple, fateful question: Should the United Kingdom remain a part of the European Union, or should it leave? Nearly 52%—a majority of 1.3 million—wanted out, and conservative politicians vowed to carry out the people’s wishes. [ScienceInsider] Editorial

There’s No Taboo, No Bad Ideas’: Anyone Can Help Shape European Union’s New €94 Billion Research Program

These encouraging words were spoken here last week at the European Research and Innovation Days, where policy bigwigs working with the European Commission invited the audience to help shape Europe’s next seven-year research funding program, Horizon Europe, set to begin in 2021. Their message: Anyone can help “cocreate” the program’s outlines. [ScienceInsider] Editorial

NEW Tissue Engineering and Regenerative Medicine International Society European Chapter Meeting 2020
May 26-29, 2020
Manchester, United Kingdom

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Research Associate – Drug and Gene Delivery Research (University of Pittsburgh)

Postdoctoral Associate – Vascular Disease (University of Miami)

Full Professorship – Translational Vascular Biomedicine (Charité – University Medicine Berlin)

Postdoctoral Fellow – Ophthalmology (The University of Tennessee Health Science Center)

Postdoctoral Fellow and Graduate Student – Cardiovascular Sciences (University of Calgary)

Research Associate – Vascular and Skeletal Biology (Imperial College London)

Postdoctoral Position – Liver Macrophage Niche (Flanders Institute for Biotechnology)

Postdoctoral Position – Alzheimer’s disease (Icahn School of Medicine)

Postdoctoral Position – Vascular Biology (New York University Winthrop Hospital)

PhD and Postdoctoral Positions – Neurovascular Biology (Université Libre de Bruxelles)

Postdoctoral Position – Endothelial Cell Research (The University of Tennessee Health Science Center)

Faculty Positions – Basic and Translational Cardiovascular Sciences (New York University)

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