Endothelial Cell News Volume 4.38 | Nov 18 2019

TOP STORY

Short-Term E-Cigarette Vapor Exposure Causes Vascular Oxidative Stress and Dysfunction: Evidence for a Close Connection to Brain Damage and a Key Role of the Phagocytic NADPH Oxidase (NOX-2)

Acute e-cigarette smoking produced a marked impairment of endothelial function in chronic smokers determined by flow-mediated dilation. In mice, e-cigarette vapor without nicotine had more detrimental effects on endothelial function, markers of oxidative stress, inflammation, and lipid peroxidation than vapor containing nicotine. [Eur Heart J] Full Article | Press Release

(Ranked by impact factor of the journal)

A Systems-Based Map of Human Brain Cell-Type Enriched Genes and Malignancy-Associated Endothelial Changes

Scientists provided a roadmap of endothelial cell identity in normal and malignant brains, using a method developed to resolve bulk RNA-seq into constituent cell-type-enriched profiles. [Cell Rep] Full Article | Graphical Abstract

Lung Mammary Metastases but Not Primary Tumors Induce Accumulation of Atypical Large Platelets and Their Chemokine Expression

To test whether endothelial cells (ECs) associated with lung metastases express a distinct gene expression program that promotes metastatic growth, researchers isolated CD31⁺/CD45^– cells from lung mammary cancer metastases for RNA sequencing and found CD44 upregulation. Unexpectedly, the CD44⁺ subset did not comprise authentic ECs nor were they bone-marrow-derived CD45^– endothelial progenitor cells. [Cell Rep] Full Article | Graphical Abstract

Hepatocyte-Derived Exosomal miR-194 Activates PMVECs and Promotes Angiogenesis in Hepatopulmonary Syndrome

Investigators found that hepatopulmonary syndrome rat serum exosomes (HEs) significantly enhanced PMVEC proliferation, migration, and tube formation. They further identified miR-194 was the most notably increased miRNA in HEs compared to sham-operated rat serum exosomes. [Cell Death Dis] Full Article

Neurons Can Upregulate Cav-1 to Increase Intake of Endothelial Cells-Derived Extracellular Vesicles That Attenuate Apoptosis via miR-1290

In a HUVEC-neuron co-culture assay, researchers found that HUVECs reduced apoptosis of neurons under oxygen-glucose deprivation, and this effect was compromised by GW4869, a blocker of exosome release. [Cell Death Dis] Full Article

MicroRNA-148a/b-3p Regulates Angiogenesis by Targeting Neuropilin-1 in Endothelial Cells

The authors found that miR-148a/b-3p expression was significantly downregulated during the differentiation of umbilical cord blood mononuclear cells into outgrowing endothelial cells (ECs) and that decreased miR-148a/b-3p levels were closely related to EC behavior. [Exp Mol Med] Full Article

MicroRNA-326-5p Enhances Therapeutic Potential of Endothelial Progenitor Cells for Myocardial Infarction

miR-326-5p significantly enhanced the angiogenic capacity of endothelial progenitor cells (EPCs). Transplantation of miR-326-5p-overexpressing EPCs improved cardiac function for acute myocardial infarction therapy. [Stem Cell Res Ther] Full Article

PRAS40 Suppresses Atherogenesis through Inhibition of mTORC1-Dependent Pro-Inflammatory Signaling in Endothelial Cells

Knockdown of PRAS40 in endothelial cells promoted TNFα-induced mTOR complex 1 (mTORC1) signaling, proliferation, upregulation of inflammatory markers and monocyte recruitment. [Sci Rep] Full Article

Sex-Dependent VEGF Expression Underlies Variations in Human Pluripotent Stem Cell to Endothelial Progenitor Differentiation

While male human pluripotent stem cells (hPSCs) efficiently differentiated into CD34⁺ CD31⁺ endothelial progenitors upon GSK3 inhibition, female hPSCs showed limited differentiation capacity using this protocol. [Sci Rep] Full Article

Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News.

Tumor Angiogenesis: Causes, Consequences, Challenges and Opportunities

Scientists summarize the current understanding of cellular and molecular mechanisms involved in tumor angiogenesis and discuss challenges and opportunities associated with vascular targeting. [Cell Mol Life Sci] Abstract

Visit our reviews page to see a complete list of reviews in the endothelial cell research field.

New Novartis Medicine Adakveo^® (Crizanlizumab) Approved by FDA to Reduce Frequency of Pain Crises in Individuals Living with Sickle Cell Disease

Novartis announced that the FDA approved Adakveo^®, previously known as SEG101, to reduce the frequency of vaso-occlusive crises, or pain crises, in adult and pediatric patients aged 16 years and older with sickle cell disease. [Novartis] Press Release

Ohio State’s Heart and Vascular Center Names 2019 Schottenstein Laureate

The Ohio State University Wexner Medical Center’s Heart and Vascular Center has named Dr. Dan Roden, senior vice president for Personalized Medicine at Vanderbilt University Medical Center, as recipient of the 2019 Jay and Jeanie Schottenstein Prize in Cardiovascular Sciences. [The Ohio State University Wexner Medical Center] Press Release

Move by Journals to ‘Seamless’ Off-Campus Access Raises Privacy Concerns

One major publisher- the Nature family of journals- launched an effort to make things easier for off- campus readers. It became the first to offer a consistent, streamlined method of access, through a standard button displayed prominently atop articles in its 150 journals. But the project has raised concerns among some university librarians, who say it could ultimately allow publishers to obtain personally identifiable data about researchers without their knowledge. [ScienceInsider] Editorial

Italy to Launch National Agency for Research

Just two months after Italy underwent a crisis of government and established an alliance between two leading political parties, the left-of-center Democratic Party and the anti-establishment Five Star Movement, the country has announced plans to start a National Agency for Research to help oversee the distribution of federal funds. [The Scientist] Editorial

NEW Understanding Endothelial Cell Diversity: Regulation and Regenerative Potential
June 28-July 3, 2020
Barcelona, Spain

Visit our events page to see a complete list of events in the community.

NEW PhD Student – Organoid Culture (University Hospital Leipzig)

NEW Postdoctoral Positions – Endothelial Cell Biology (Aarhus University)

NEW Research Fellow – Vascular Stem Cell Biology (Queen’s University Belfast)

NEW Faculty Positions – Tissue Regeneration Engineering (Dankook University)

NEW Postdoctoral Fellow – 3D In Vitro Vascular Models (European Molecular Biology Laboratory)

Postdoctoral Researcher – Endothelial Dysfunction and Atherosclerosis (Karolinska Institutet)

Postdoctoral Fellow – Endothelial Cell Ion Channels (The University of Tennessee Health Science Center)

Postdoctoral Fellow – Endothelial Dysfunction and Malaria (Seattle Children’s Research Institute)

Postdoctoral Research Associate – Drug and Gene Delivery Research (University of Pittsburgh)

Postdoctoral Associate – Vascular Disease (University of Miami)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Endothelial Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.