Endothelial Cell News Volume 4.39 | Nov 25 2019

TOP STORY

Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis

The endothelial PTEN/Akt pathway increased monocarboxylic acid transporter 1 expression to enhance lactate transport across the brain endothelium. [Cell Stem Cell] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

Apelin⁺ Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury

Investigators showed that loss of hematopoietic cells per se, in response to irradiation and other treatments, triggered vessel dilation, permeability, and endothelial cell proliferation. [Cell Stem Cell] Full Article | Graphical Abstract

Brain-to-Cervical Lymph Node Signaling after Stroke

In rats subjected to focal cerebral ischemia, lymphatic endothelial cells proliferated and macrophages were rapidly activated in cervical lymph nodes within 24 hours, in part via VEGF-C/VEGFR3 signaling. Blockade of VEGFR3 reduced lymphatic endothelial activation, decreased pro-inflammatory macrophages, and reduced brain infarction. [Nat Commun] Full Article

The Effect of Substance P/Heparin Conjugated PLCL Polymer Coating of Bioinert ePTFE Vascular Grafts on the Recruitment of Both ECs and SMCs for Accelerated Regeneration

A double coating of heparin-conjugated PLCL and Substance P-conjugated PLCL at four weeks showed markedly improved vascular remodeling through the recruitment of mesenchymal stem cells (MSCs), vascular cells (ECs, SMCs) and M2 macrophages. [Sci Rep] Full Article

Activation of Heme Oxygenase-1 by Ginkgo biloba Extract Differentially Modulates Endothelial and Smooth Muscle-Like Progenitor Cells for Vascular Repair

A bone marrow transplantation mouse model was used to evaluate the in vivo effects of Ginkgo biloba extract treatment on wire-injury induced neointimal hyperplasia, which is representative of impaired vascular repair. [Sci Rep] Full Article

B Lymphocyte Stimulator Modulates Number and Function of Endothelial Progenitor Cells in Systemic Lupus Erythematosus

Endothelial progenitor cells (EPCs) and endothelial cells preferentially expressed B cell activating factor-receptor which could be involved in the pro-apoptotic effect of B lymphocyte stimulator. Belimumab administration restored the quantitative and qualitative changes of EPC colonies both ex vivo and in vitro. [Arthritis Res Ther] Full Article

Thrombin Inhibition by Dabigatran Attenuates Endothelial Dysfunction in Diabetic Mice

Thrombin significantly impaired the endothelium-dependent vascular response of aortic rings obtained from wild-type mice. Inhibition of NF-κB attenuated thrombin-induced inflammatory molecule expression in HUVECs and ameliorated thrombin-induced endothelial dysfunction in aortic rings. [Vascul Pharmacol] Abstract | Graphical Abstract

Repression of MicroRNA-21 Inhibits Retinal Vascular Endothelial Cell Growth and Angiogenesis via PTEN Dependent-PI3K/Akt/VEGF Signaling Pathway in Diabetic Retinopathy

PTEN was targeted and negatively regulated by miR-21, while the phosphatidylinositiol 3-kinase/protein kinase B (PI3K/Akt)/VEGF signaling pathway was activated by miR-21. Retinal vascular endothelial cells transfected with miR-21 inhibitor exhibited promoted viability and angiogenesis, and inhibited apoptosis. [Exp Eye Res] Abstract

Treatment of Corneal Endothelial Damage in a Rabbit Model with a Bioengineered Graft Using Human Decellularized Corneal Lamina and Cultured Human Corneal Endothelium

Scientists investigated the functionality of human decellularized stromal laminas seeded with cultured human corneal endothelial cells as a tissue engineered endothelial graft construct to perform endothelial keratoplasty in an animal model of corneal endothelial damage. [PLoS One] Full Article

Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News.

Heterogeneity of Vascular Endothelial Cells, De Novo Arteriogenesis and Therapeutic Implications in Pancreatic Neuroendocrine Tumors

The authors describe endothelial cell (EC) heterogeneity and heterogeneous tumor-associated ECs in the tumor microenvironment (TME) and emphasize the concept of de novo arteriogenesis in the TME. [J Clin Med] Abstract

Visit our reviews page to see a complete list of reviews in the endothelial cell research field.

Chi-Med Announces NDA Acceptance in China for Surufatinib in Non-Pancreatic Neuroendocrine Tumors

Hutchison China MediTech Limited (Chi-Med) announced that its New Drug Application (NDA) for surufatinib for the treatment of patients with advanced non-pancreatic neuroendocrine tumors has been accepted for review by the China National Medical Products Administration. [Hutchison China MediTech Limited] Press Release

UK Professor Honored for Contributions to Cardiovascular Science and Medicine

University of Kentucky (UK) Professor of Pharmacology and Nutritional Sciences Nancy Webb, PhD, has been honored by the American Heart Association with the Arteriosclerosis, Thrombosis, and Vascular Biology Distinguished Achievement Award. [University of Kentucky] Press Release

Science Funders Gamble on Grant Lotteries

The Health Research Council of New Zealand is one of a growing number of funders that award grants partly through random selection. [Nature News] Editorial

The Science Institutions Hiring Integrity Inspectors to Vet Their Papers

Some researchers have their manuscripts screened for errors before they go to journals. [Nature News] Editorial

Foreign Interference Fears Prompt Guidelines for Australian Universities

New guidelines will help Australian universities protect themselves against foreign interference, says the country’s government. The advice follows concerns that foreign groups or governments, such as the government of China, might be seeking to instigate campus activities that are against Australia’s interests. [Nature News] Editorial

NEW Advancing Precision Medicine Drug Development: Incorporation of Real-World Data and Other Novel Strategies
January 9-12, 2020
San Diego, California, United States

Visit our events page to see a complete list of events in the community.

NEW Assistant or Associate Professor – Cardiovascular or Renal Physiology and Pharmacology (University of Southern Denmark)

NEW Postdoctoral Researcher – Vascular Biology (University Medical Center Hamburg-Eppendorf)

PhD Student – Organoid Culture (University Hospital Leipzig)

Postdoctoral Positions – Endothelial Cell Biology (Aarhus University)

Research Fellow – Vascular Stem Cell Biology (Queen’s University Belfast)

Faculty Positions – Tissue Regeneration Engineering (Dankook University)

Postdoctoral Fellow – 3D In Vitro Vascular Models (European Molecular Biology Laboratory)

Postdoctoral Fellow – Endothelial Cell Ion Channels (The University of Tennessee Health Science Center)

Postdoctoral Fellow – Endothelial Dysfunction and Malaria (Seattle Children’s Research Institute)

Postdoctoral Research Associate – Drug and Gene Delivery Research (University of Pittsburgh)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Endothelial Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.