Endothelial Cell News Volume 5.01 | Jan 13 2020

TOP STORY

The Entry of Nanoparticles into Solid Tumors

Researchers showed that inter-endothelial gaps were not responsible for the transport of nanoparticles into solid tumors. Instead, they found that up to 97% of nanoparticles entered tumors using an active process through endothelial cells. [Nat Mater] Abstract | Press Release

(Ranked by impact factor of the journal)

An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates

Scientists single-cell RNA-sequenced 56,771 endothelial cells from human/mouse (peri)-tumoral lung and cultured human lung tumor endothelial cell (TECs), and detected 17 known and 16 previously unrecognized phenotypes, including TECs putatively regulating immune surveillance. [Cancer Cell] Abstract | Graphical Abstract

Microengineered Human Blood-Brain Barrier Platform for Understanding Nanoparticle Transport Mechanisms

Investigators present a microphysiological platform that recapitulated the key structure and function of the human blood-brain barrier and enabled 3D mapping of nanoparticle distributions in the vascular and perivascular regions. [Nat Commun] Full Article

Neutrophil Microvesicles Drive Atherosclerosis by Delivering miR-155 to Atheroprone Endothelium

Using cultured endothelial cells exposed to disturbed flow, the authors demonstrated that neutrophil microvesicles promoted inflammatory gene expression by delivering miR-155, enhancing NF-κB activation. [Nat Commun] Full Article

Complex Interrelationships between Nitro-Alkene-Dependent Inhibition of Soluble Epoxide Hydrolase, Inflammation and Tumor Growth

Nitro-oleate increased migration in endothelial cells isolated from wild-type mice, but not those from C521S soluble epoxide hydrolase knock-in transgenic mice genetically modified to render the hydrolase electrophile-resistant. [Redox Biol] Full Article | Graphical Abstract

The CXCR2/CXCL2 Signaling Pathway – An Alternative Therapeutic Approach in High-Grade Glioma

In vitro analyses of CXCR2-antagonist (SB225002) showed its direct impact on proliferation of glioma and endothelial cells if used at higher concentrations. In addition, expression of CXCR2/CXCL2 signaling genes was increased in both cell types by SB225002, but VEGF-relevant genes were unaffected. [Eur J Cancer] Abstract

Skip Is Essential for Notch Signaling to Induce Sox2 in Cerebral Arteriovenous Malformations

Investigators identified high expression of ski-interacting protein (Skip) in brain endothelial cells (ECs), a Notch-associated chromatin-modifying protein that was lacking in lung ECs. [Cell Signal] Abstract

Anosmin-1 Activates Vascular Endothelial Growth Factor Receptor and Its Related Signaling Pathway for Olfactory Bulb Angiogenesis

Cell migration, proliferation, and tube formation of endothelial cells were induced by treatment with anosmin-1 as well as vascular endothelial growth factor-A, and further enhanced by treatment with both of them. [Sci Rep] Full Article

Exosomal miR-146a-5p from Treponema pallidum-Stimulated Macrophages Reduces Endothelial Cells Permeability and Monocyte Transendothelial Migration by Targeting JAM-C

Scientists showed that exosomal miR-146a-5p was efficiently transported into endothelial cells, reducing monocyte transendothelial migration and endothelial permeability by targeting junctional adhesion molecule C (JAM-C). [Exp Cell Res] Abstract | Graphical Abstract

MicroRNA-384-5p Promotes Endothelial Progenitor Cell Proliferation and Angiogenesis in Cerebral Ischemic Stroke through the Delta-Likeligand 4-Mediated Notch Signaling Pathway

Researchers explored the effect of miR-384-5p on proliferation, apoptosis, and angiogenesis of endothelial progenitor cells in cerebral ischemic stroke and investigated the associated underlying mechanism. [Cerebrovasc Dis] Abstract

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Crosstalk between Tubular Epithelial Cells and Glomerular Endothelial Cells in Diabetic Kidney Disease

The authors summarize the current knowledge on the crosstalk between tubular epithelial cells and glomerular endothelial cells in the pathogenesis of diabetic kidney disease and highlight specific clinical and potential therapeutic strategies. [Cell Prolif] Full Article

The Effects of Diabetes Mellitus on the Corneal Endothelium: A Review

Scientists discuss the specifics of how diabetes mellitus impacts the corneal endothelium including alterations in cell morphology, cell density, ultrastructure, pump and barrier function, cataract surgery outcomes, and corneal transplant outcomes with attention to the use of diabetic donor tissue and diabetic transplant recipients. [Surv Ophthalmol] Abstract

Visit our reviews page to see a complete list of reviews in the endothelial cell research field.

Mereo BioPharma and Oncologie Enter into Global Licensing Agreement for Navicixizumab

Mereo BioPharma Group plc and Oncologie, Inc. announced a global license agreement for the development and commercialization of navicixizumab, an anti-DLL4/VEGF bispecific antibody currently being evaluated in an ongoing Phase Ib study in combination with paclitaxel in patients with advanced heavily pretreated ovarian cancer. [Mereo BioPharma Group plc] Press Release

Exonate Announces Collaboration with Janssen to Develop a New Eye Drop for the Treatment of Retinal Vascular Diseases Including Wet Age-related Macular degeneration (AMD) and Diabetic Macular Oedema (DMO)

Exonate announced that it has entered into a strategic collaboration agreement with Janssen Pharmaceuticals, Inc. Through the collaboration, Exonate will work with Janssen Research & Development, LLC scientists to develop an eye drop treatment for retinal vascular diseases such as wet AMD and DMO by using mRNA targeted therapies. [Exonerate Ltd. (PR Newswire Association LLC)] Press Release

IDEAYA Biosciences and Boston Children’s Hospital Collaborate on Preclinical Evaluation of IDE196 for Sturge Weber Syndrome – a Rare Disease Associated with Genetic Mutation of GNAQ

IDEAYA Biosciences, Inc. announced that the company has entered into a Sponsored Research Agreement with Boston Children’s Hospital for preclinical evaluation of the role of protein kinase C in Sturge Weber syndrome, a rare neurocutaneous disorder characterized by capillary malformations and associated with mutations in GNAQ. [IDEAYA Biosciences, Inc.] Press Release

FDA and NIH Let Clinical Trial Sponsors Keep Results Secret and Break the Law

For 20 years, the US government has urged companies, universities, and other institutions that conduct clinical trials to record their results in a federal database, so doctors and patients can see whether new treatments are safe and effective. Few trial sponsors have consistently done so, even after a 2007 law made posting mandatory for many trials registered in the database. [ScienceInsider] Editorial

Predatory-Journal Papers Have Little Scientific Impact

Papers published in ‘predatory’ journals attract little attention from scientists, and get cited much less than those in reputable publications, an analysis shows. Predatory journals are those that charge authors high article-processing fees but don’t provide expected publishing services, such as peer review or other quality checks. [Nature News] Editorial

NEW FEBS3+ Life Sciences Switzerland
February 13-14, 2020
Zurich, Switzerland

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NEW Postdoctoral Fellow – Endothelial Biology (City of Hope)

NEW Postdoctoral Researcher (University of Illinois at Chicago)

NEW Tenure Track Faculty – Endothelial Cell Regeneration (Ohio State University)

NEW Post-Doctoral Fellow – Metabolic Regulation of Vascular Formation (Oklahoma Medical Research Foundation)

NEW Postdoctoral Position (University Hospital of Muenster)

NEW PhD Student (University Hospital Carl Gustav Carus Dresden)

Postdoctoral Research Fellow – Pulmonary Vascular Diseases (Boston Children’s Hospital)

PhD Student – Aortic Disease (University Hospital of Cologne)

Postdoctoral Research Fellow – Aortic Disease (University Hospital of Cologne)

Postdoctoral Positions – Bioinformatics and Vascular Biology (KU Leuven)

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