Endothelial Cell News Volume 5.03 | Jan 27 2020

TOP STORY

Rapid Intestinal Uptake and Targeted Delivery to the Liver Endothelium Using Orally Administered Silver Sulfide Quantum Dots

Scientists demonstrated rapid absorption across the small intestine and targeted delivery of quantum dots with bound materials to liver sinusoidal endothelial cells or hepatocytes in vitro and in vivo following oral administration. [ACS Nano] Abstract

(Ranked by impact factor of the journal)

Culture of Pulmonary Arterial Endothelial Cells from Pulmonary Artery Catheter Balloon Tips: Considerations for Use in Pulmonary Vascular Disease

The authors cultured pulmonary artery endothelial cells (PAECs) from pulmonary artery catheter balloons used during right heart catheterization, to characterize successful culture attempts and to describe PAEC behavior. [Eur Respir J] Abstract

Lymphatic Endothelial Cells Prime Naïve CD8⁺ T Cells into Memory Cells under Steady-State Conditions

Researchers showed that while many proliferating lymphatic endothelial cell-educated T cells entered early apoptosis, the remainders comprised a long-lived memory subset, with transcriptional, metabolic, and phenotypic features of central memory and stem cell-like memory T cells. [Nat Commun] Full Article

Endothelial ZEB1 Promotes Angiogenesis-Dependent Bone Formation and Reverses Osteoporosis

Investigators showed that the zinc-finger transcription factor ZEB1 was predominantly expressed in CD31^hiendomucin^hi endothelium in human and mouse bone. Endothelial cell-specific deletion of ZEB1 in mice impaired CD31^hiendomucin^hi vessel formation in the bone, resulting in reduced osteogenesis. [Nat Commun] Full Article

Molecular Adaptations of the Blood-Brain Barrier Promote Stress Resilience vs. Depression

Scientists identified active molecular changes within the blood-brain barrier associated with stress resilience that could serve a protective role for the neurovasculature. They also confirmed the relevance of such changes to human depression and antidepressant treatment. [Proc Natl Acad Sci USA] Full Article

Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy

Researchers showed in primary mouse lung cancer that normalization of tumor vasculature by LIGHT and a vascular targeting peptide (VTP) prevented cancer cell intravasation. Further, LIGHT-VTP efficiently targeted pathological blood vessels in the pre-metastatic niche, reducing vascular hyper-permeability and extracellular matrix deposition, thus blocking metastatic lung colonization. [Cell Rep] Full Article | Graphical Abstract

Hematopoietic Stem and Progenitor Cells Use Podosomes to Transcellularly Cross the Bone Marrow Endothelium

Using an in vitro migration assay, invextigators showed that human hematopoietic stem and progenitor cells predominantly crossed bone marrow endothelium in a transcellular manner in homeostasis by inducing podosome-like structures. [Haematologica] Abstract

A Regulatory MicroRNA Network Controls Endothelial Cell Phenotypic Switch during Sprouting Angiogenesis

Scientists investigated the regulatory role of microRNAs in harmonizing angiogenesis processes in a three-dimensional in vitro model. They described a microRNA network which contributed to the observed down- and upregulation of proliferative and migratory genes, respectively. [eLife] Full Article

YAP1 and TAZ Negatively Control Bone Angiogenesis by Limiting Hypoxia-Inducible Factor Signaling in Endothelial Cells

With mouse genetics, RNA sequencing, biochemistry, and cell culture experiments, investigators showed that Yap1/Taz constrained hypoxia-inducible factor 1α targeted gene expression in vivo and in vitro. [eLife] Full Article

Robotic Fluidic Coupling and Interrogation of Multiple Vascularized Organ Chips

A robotic interrogator maintained the viability and organ-specific functions of eight vascularized, two-channel organ chips for three weeks in culture when intermittently fluidically coupled via a common blood substitute through their reservoirs of medium and endothelium-lined vascular channels. [Nat Biomed Eng] Abstract

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Vascularized Biomaterials to Study Cancer Metastasis

The authors focus on current methods of vascularizing biomaterials for the study of cancer, and three main factors that regulate intravasation and extravasation: endothelial cell heterogeneity, hemodynamics, and the extracellular matrix of the perivascular niche. [Adv Healthc Mater] Abstract

Visit our reviews page to see a complete list of reviews in the endothelial cell research field.

Akari Therapeutics Announces Preclinical Ophthalmic Data Showing Nomacopan Reduces Both Vascular Endothelial Growth Factor (VEGF) and Retinal Inflammation Supporting Nomacopan as a Potential Treatment Option for Back-of-the-Eye Diseases

Akari Therapeutics, Plc announced new preclinical data indicating that nomacopan significantly reduced both retinal inflammation and intraocular VEGF. [Akari Therapeutics, Plc] Press Release

Genentech Submits Supplemental Biologics License Application to the FDA for Tecentriq in Combination With Avastin for the Most Common Form of Liver Cancer

Genentech announced the completion of a supplemental Biologics License Application submission to the FDA for Tecentriq^® in combination with Avastin^® for the treatment of people with unresectable hepatocellular carcinoma who have not received prior systemic therapy. [Genentech, Inc.] Press Release

Brazil’s Pick of a Creationist to Lead Its Higher Education Agency Rattles Scientists

The appointment of a creationism advocate to lead the agency that oversees Brazil’s graduate study programs has scientists here concerned – yet again – about the encroachment of religion on science and education policy. President Jair Bolsonaro’s administration on Saturday January 25^th named Benedito Guimarães Aguiar Neto to head the agency, known as CAPES, who previously served as the rector for a private religious school which advocates the teaching and study of intelligent design. [ScienceInsider] Editorial

US Officials Revisit Rules for Disclosing Risky Disease Experiments

US disease researchers are pushing the government to be more transparent about federally funded research that involves making pathogens more deadly or more transmissible. Several disease researchers who attended a recent meeting to discuss transparency around such studies say the US government should offer a public explanation when it approves such ‘gain-of-function’ experiments, disclose who made the decision to fund them and make a broad public announcement when a study begins. [Nature News] Editorial

NEW International Society for Stem Cell Research (ISSCR)
June 24-27, 2020
Boston, Massachusetts, United States

Visit our events page to see a complete list of events in the community.

NEW PhD Position – Aging (Lausanne University Hospital)

Postdoctoral Fellow – Vascular Dysfunction in Neurodegeneration (Lund University)

Postdoctoral Fellow – Endothelial Biology (City of Hope)

Postdoctoral Researcher (University of Illinois at Chicago)

Tenure Track Faculty – Endothelial Cell Regeneration (Ohio State University)

Post-Doctoral Fellow – Metabolic Regulation of Vascular Formation (Oklahoma Medical Research Foundation)

Postdoctoral Position (University Hospital of Muenster)

PhD Student (University Hospital Carl Gustav Carus Dresden)

Postdoctoral Research Fellow – Pulmonary Vascular Diseases (Boston Children’s Hospital)

PhD Student – Aortic Disease (University Hospital of Cologne)

Postdoctoral Research Fellow – Aortic Disease (University Hospital of Cologne)

Postdoctoral Positions – Bioinformatics and Vascular Biology (KU Leuven)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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