Endothelial Cell News 5.05 February 10, 2020 | |
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TOP STORYThe Guidance Receptor Plexin D1 Is a Mechanosensor in Endothelial Cells Researchers showed that plexin D1 (PLXND1) had a role in mechanosensation and mechanically induced disease pathogenesis. PLXND1 was required for the response of endothelial cells to shear stress in vitro and in vivo and regulated the site-specific distribution of atherosclerotic lesions. [Nature] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)(OEG2)2-IP4 potently stabilized calciprotein particle growth, consistently demonstrated low micromolar activity in different in vitro models of vascular calcification (VC), and largely abolished the development of VC in rodent models, while not causing toxicity related to serum calcium chelation. [Nat Commun] Full Article Using single-cell transcriptome analysis and antibody screening, investigators identified CD44 as a marker of endothelial to hematopoietic transition (EHT) enabling them to isolate robustly the different stages of EHT in the aorta-gonad-mesonephros region. They provided a detailed phenotypical and transcriptional profile of CD44-positive arterial endothelial cells from which hematopoietic stem and progenitor cells emerged. [Nat Commun] Full Article BMP9 Signaling Promotes the Normalization of Tumor Blood Vessels BMP9 overexpression in Lewis Lung Carcinoma (LLC) tumors significantly delayed tumor growth. Blood vessels in BMP9-overexpressing LLC tumors displayed markers of vascular maturation and were characterized by increased perivascular cell coverage. [Oncogene] Full Article Both in vitro and in vivo, HIPK2 inhibited the migration of HCC cells, as well as tumor growth and metastasis in xenograft and orthotopic syngeneic hepatocellular carcinoma (HCC) mouse models. Furthermore, HIPK2 inhibited the angiogenesis in HCC tumors. [Oncogene] Full Article The authors report that increased endothelial sprouting in human-amyloid precursor protein (APP) transgenic mouse tissue was dependent on β-secretase processing of APP. Higher levels of amyloid beta peptides processing in TgCRND8 tissue coincided with decreased NOTCH3/JAG1 signalling, overproduction of endothelial filopodia and increased numbers of vascular pericytes. [Cell Death Dis] Full Article Researchers showed that α-linolenic acid but not linolenic acid supplementation alleviated systolic blood pressure elevation and improved ACh-induced, endothelium-dependent vasodilation in both spontaneously hypertensive rats (SHRs) and AngII-induced hypertensive mice [Cell Death Dis] Full Article Developing a Xenograft Model of Human Vasculature in the Mouse Ear Pinna Human subcutaneous fat was cultured in vitro to promote blood vessel outgrowth prior to implantation into immunocompromised mice. The authors demonstrated that implants survived, retained human vasculature and anastomosed with the circulatory system of the recipient mouse. [Sci Rep] Full Article Human dermal fibroblasts were used as comparator cells. Transcription factor (TF), FVII, FIX, FX, and prothrombin were detected in endothelial cells, and TF, coagulation factor (F)VII, FIX, and FX were detected in fibroblasts. In addition, FVII, FIX, FX, and prothrombin were detected by fluorescent microscopy in endothelial cells cytoplasm. [Sci Rep] Full Article Conjugated Polymers Optically Regulate the Fate of Endothelial Colony Forming Cells Researchers demonstrated that polymer-mediated optical excitation induced a robust enhancement of proliferation and lumen formation in vitro. They identified the underlying biophysical pathway as due to light-induced activation of TRPV1 channel. [Biophys J] Abstract Investigators observed that lymphatic endothelial cells replicated aspects of the early steps in valvulogenesis: cells oriented perpendicular to flow in the region of maximum wall shear stress and exhibited enhanced nuclear localization of FOXC2, a transcription factor required for valvulogenesis. [Commun Biol] Full Article Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSCheckpoint Inhibitor Immunotherapy in Kidney Cancer Data has led to approvals of combination strategies of immune checkpoint inhibition plus agents that target the vascular endothelial growth factor receptor and a shift in the current standard of renal cell carcinoma care. However, controversies remain regarding the optimal therapy selection and treatment strategy for individual patients, which might be eventually overcome by current intensive efforts in biomarker research. [Nat Rev Urol] Abstract Long Noncoding RNAs as Novel Players in the Pathogenesis of Hypertension The authors summarize the current studies of long non-coding (lnc)RNAs in the pathogenesis of hypertension in order to aid in better understanding the molecular mechanism of hypertension and provide a basis to explore new therapeutic targets. [Hypertens Res] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSAlkahest, Inc. announced the dosing of the first patient in a Phase II clinical trial of AKST4290, an orally administered CCR3 inhibitor, for treatment of Parkinson’s disease. The trial, AKST4290-211, is funded in part by The Michael J. Fox Foundation for Parkinson’s Research and will evaluate the effect of AKST4290 on motor function and activities of daily living in patients with Parkinson’s disease. [Alkahest, Inc.] Press Release Researchers to Investigate Method of Growing New Blood Vessels A potential new treatment is to increase the blood flow to damaged heart tissue by using drugs that encourage the body to grow new blood vessels. The project will be led by Professor Paolo Madeddu, Chair of Experimental Cardiovascular Medicine at the University of Bristol, who, along with his team, discovered that an excess of a protein called BACH1 can prevent blood vessel formation. [University of Bristol] Press Release | |
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POLICY NEWSTrump’s 2021 Budget Drowns Science Agencies in Red Ink, Again It’s another sea of red ink for federal research funding programs in President Donald Trump’s latest budget proposal. The 2021 budget request to Congress released February 10th calls for deep, often double-digit cuts to R&D spending at major science agencies. [ScienceInsider] Editorial Major Cancer Institute Sued by Its Own Researchers Over ‘Tapering’ Funding Alleging that a leading cancer funder is slashing their support in an “unethical and reckless” way, six prominent cancer researchers at the University of California, San Diego, have filed a lawsuit to compel it to continue its current level of support. [ScienceInsider] Editorial
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EVENTSNEW First International STEMNET Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Researcher – Microvascular Injury (University Hospital Carl Gustav Carus Dresden) Postdoctoral Researcher – Human Atherosclerosis (Karolinska Institutet) PhD Position – Aging (Lausanne University Hospital) Postdoctoral Fellow – Vascular Dysfunction in Neurodegeneration (Lund University) Postdoctoral Researcher (University of Illinois at Chicago) Tenure Track Faculty – Endothelial Cell Regeneration (Ohio State University) Postdoctoral Research Fellow – Pulmonary Vascular Diseases (Boston Children’s Hospital) PhD Student – Aortic Disease (University Hospital of Cologne) Postdoctoral Positions – Bioinformatics and Vascular Biology (KU Leuven) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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