Endothelial Cell News 5.09 March 16, 2020 | |
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TOP STORYResearchers found that the internalized bacterial endotoxin lipopolysaccharide (LPS) activated the pore-forming protein Gasdermin D, which formed mitochondrial pores and induced mitochondrial DNA (mtDNA) release into the cytosol of endothelial cells. mtDNA was recognized by the DNA sensor cGAS and generated the second messenger cGAMP, which suppressed endothelial cell proliferation by downregulating YAP1 signaling. [Immunity] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators evaluated the impact of lipoprotein (Lp)(a) on the endothelium and described that Lp(a), through its oxidized phospholipid content, activated arterial endothelial cells (ECs), facilitating increased transendothelial migration of monocytes. Transcriptome analysis of Lp(a)-stimulated human arterial ECs revealed upregulation of inflammatory pathways comprising monocyte adhesion and migration, coinciding with increased 6-phophofructo-2-kinase/fructose-2,6-biphosphatase 3-mediated glycolysis. [Circ Res] Abstract The authors showed that miR-181b-5p, an angiogenesis-promoting miRNA of esophageal squamous cell carcinoma (ESCC), could be transferred from ESCC cells to vascular endothelial cells via extracellular vesicles (EVs). ESCC-derived EVs-miR-181b-5p dramatically induced angiogenesis by targeting PTEN and PHLPP2, and thereby facilitated tumor growth and metastasis. [Mol Ther Nucleic Acids] Abstract | Full Article Scientists demonstrated that transforming growth factor-beta-1 (TGF-β1) stimulated VEGF expression in and secretion from both immortalized human granulosa-lutein (hGL) cells and primary hGL cells. They demonstrated that the SMAD2/3, ERK1/2, and p38 MAPK signaling pathways were involved in TGF-β1-induced VEGF expression and secretion. [Exp Mol Med] Full Article The authors studied ear arteriovenous malformations (AMVs) to determine if overgrown cartilage contained AVM-causing mutations. Cartilage was separated from its surrounding tissue and isolated by laser capture microdissection. Droplet digital PCR was used to identify MAP2K1 mutations. [Sci Rep] Full Article Human coronary artery endothelial cells stimulated with sera from patients with Kawasaki disease, compared with sera from healthy children, exhibited significant increases in proliferation and angiogenesis, higher levels of nuclear factor of activated T-cells (NFAT)c1 and NFATc3 and some inflammatory molecules, and increased nuclear translocation of NFATc1 and NFATc3. [Sci Rep] Full Article Two active molecules, GRGDS and sitagliptin, were chosen for their abilities to recruit, enhance adhesion and induce differentiation of endothelial progenitor cells (EPCs). They were grafted on PET surfaces in order to provide restrained cues triggering cell alignment and evaluate the influence of such structuration on EPCs fate. [J Biomed Mater Res A] Abstract Researchers tested the contribution of N-myc downstream regulated gene 1 (NDRG1) to VEGF-A-induced angiogenesis in vascular endothelial cells. Ndrg1−/− mice exhibited impaired VEGF-A-induced angiogenesis in corneas. [Commun Biol] Full Article Investigators report the development of relatively simple differentiation and purification methods for human induced pluripotent stem cell-derived induced endothelial progenitor cells (iEPCs). They discovered that a combination of three small molecules-Y-27632, A 83-01, and CHIR-99021- dramatically stimulated protein synthesis-related pathways and enhanced the proliferative capacity of iEPCs. [Heliyon] Full Article Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSVasculogenic Mimicry in Carcinogenesis and Clinical Applications The authors discuss the recent studies on the role of vasculogenic mimicry (VM) in tumor progression and the diverse mechanisms and signaling pathways that regulate VM in tumors. They also summarize the latest findings of non-coding RNAs, such as lncRNAs and miRNAs in VM formation. [J Hematol Oncol] Full Article Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSAstraZeneca and MSD Inc. announced high-level results from the Phase III GY004 trial, led by NRG Oncology and sponsored by the US National Cancer Institute, that examined primarily the efficacy and safety of the potential new medicine cediranib added to Lynparza versus platinum-based chemotherapy in patients with platinum-sensitive relapsed ovarian cancer. [AstraZeneca PLC] Press Release Baylor College of Medicine and the University of Houston Announce Collaborative Grant Awardees Baylor College of Medicine and the University of Houston (UH) are teaming up for new research collaborations. The two Texas Medical Center member institutions have awarded grant funding for nine research projects, each with investigators from both schools, as part of a pilot program resulting from a 2019 Memorandum of Understanding between Baylor College of Medicine and UH to foster new partnerships and research collaborations. [Baylor College of Medicine] Press Release | |
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POLICY NEWSUK Government to Boost R&D Spending The British government has announced a 15 percent increase in public funding for research and development as part of its 2020 budget in a move that was generally welcomed by scientists. [The Scientist] Editorial Universities Are Forging Ties with the FBI as US Cracks Down on Foreign Influence US universities are forging closer ties with FBI agents, encouraging scientists to disclose foreign sources of research funding, and tightening restrictions on researchers’ travel. [Nature News] Editorial
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EVENTSNEW Tissue Engineering and Regenerative Medicine Asia-Pacific Conference 2020 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Associate – Glomerular Endothelial Cells (University of Bristol) Research Fellow – Cardiovascular Disease (Queen’s University Belfast) Postdoctoral Researcher – Endothelial Mechanotransduction (KU Leuven) Research Associate – Blood Vessel Formation (The University of Manchester) Research Fellow – Vascular Biology (Queen’s University Belfast) Postdoctoral Fellowship – Endothelial Injury in Type 2 Diabetes (Karolinska Institutet) Career Scientist – Neurosurgery and Regenerative Medicine (Mayo Clinic) PhD Position – Aging (Lausanne University Hospital) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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