Endothelial Cell News 5.10 March 23, 2020 | |
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TOP STORYResearchers used high-precision single-cell transcriptomics to unbiasedly examine the relevant endothelial cell populations at continuous developmental stages with intervals of 0.5 days from embryonic day 9.5 to embryonic day 11.0. [Cell Res] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators report that oxygen tension, which rose at birth, and the von Hippel-Lindau (VHL)-hypoxia-inducible factor 1α (Hif1α) pathway, regulated polarization and maturation of post-mitotic cerebellar granule neurons. At early postnatal stages with low germinal zone vascularization, Hif1α restrained cerebellar granule neurons-progenitor cell-cycle exit. [Neuron] Abstract | Graphical Abstract Atypical Cadherin Fat4 Orchestrates Lymphatic Endothelial Cell Polarity in Response to Flow The authors demonstrated that FAT4 functioned in a lymphatic endothelial cell autonomous manner to control cell polarity in response to flow and was required for lymphatic vessel morphogenesis throughout development. [J Clin Invest] Abstract | Graphical Abstract Researchers investigated involvement of connexin channels and paracrine signaling in radiation-induced bystander DNA damage in brain microvascular endothelial cells exposed to focused X-rays. Irradiation caused DNA damage in the directly exposed area, which propagated over several millimeters in the bystander area. [Cell Death Dis] Full Article Investigators analyzed epithelial-endothelial cross talk in the breast using isogenic non-tumorigenic vs. tumorigenic breast epithelial cell lines and primary endothelial cells. The cellular model used consisted of D492, a breast epithelial cell line with stem cell properties, and two isogenic D492-derived EMT cell lines, D492M and D492HER2. [Lab Invest] Full Article Scientists studied if melatonin regulated the response of HUVECs to chemotherapeutics. The inhibition that these agents exerted on some of the processes involved in angiogenesis, such as cell proliferation, migratory capacity or vessel formation, was enhanced by melatonin. [Sci Rep] Full Article Researchers hypothesized that delayed two-steps platelet-rich plasma (PRP) injection into the interior of grafts, accompanied with the extent of neovascularization, might theoretically promote microvessel growth inside transplanted adipose tissue. 24 nude mice were divided into three groups: blank group, single step group, and two steps group. [Sci Rep] Full Article The graft was formed using one bioink containing human foreskin dermal fibroblasts, human endothelial cells derived from cord blood human endothelial colony-forming cells, and human placental pericytes suspended in rat tail type I collagen to form a dermis followed by printing with a second bioink containing human foreskin keratinocytes to form an epidermis. [Tissue Eng Part A] Abstract Scientists describe the effects of monolayer adipose-derived extracellular vesicles (EVs), spheroid adipose-derived EVs, monolayer bone marrow-derived EVs, and spheroid bone marrow-derived EVs on HUVEC tube formation and mitochondrial respiration. [J Trauma Acute Care Surg] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSHow Hypoxia Regulate Exosomes in Ischemic Diseases and Cancer Microenvironment? The authors discuss how hypoxia affects the quantity and quality of exosomes, and review the mechanisms by which hypoxic cell‐derived exosomes regulate ischemic cell behaviors in both cancerous and noncancerous cells. [IUBMB Life] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSDr. Philip D. Kiser Receives 2020 Pisart Award for Outstanding Achievements in Vision Science Lighthouse Guild, Inc. announced that Philip D. Kiser, PharmD, PhD, is the recipient of the 2020 Pisart Award for his significant contributions to the field of vision science. [Lighthouse Guild, Inc.] Press Release Rising Research Star at Exeter Secures Prestigious Biochemical Society Award Dr Kirsty Wan, a Research Fellow at the Living Systems Institute has received the Early Career Research Award from the Biochemical Society – one of just ten scientists and researchers nationwide to be honored in the annual award scheme. [University of Exeter] Press Release | |
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Fellow – Molecular Oncology (Genentech, Inc.) NEW Postdoctoral Scientist – Gene Editing in Liver Disease (Beam Therapeutics) NEW Research Assistant – VEGF and Immune Response (Case Western Reserve University) NEW Senior Research Associate – In Vitro Disease Models (Kodiak Sciences) Research Fellow – Cardiovascular Disease (Queen’s University Belfast) Postdoctoral Researcher – Endothelial Mechanotransduction (KU Leuven) Research Fellow – Vascular Biology (Queen’s University Belfast) Career Scientist – Neurosurgery and Regenerative Medicine (Mayo Clinic) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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