Endothelial Cell News 5.14 April 20, 2020 | |
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TOP STORYResearchers present a genome-wide CRISPR-Cas9-mediated screen using a human lung carcinoma cell line and identifed semaphorin (SEMA) 6A and 6B as receptors for TcsL. Disrupting SEMA6A/6B expression in several distinct human cell lines and primary human endothelial cells resulted in reduced TcsL sensitivity, while SEMA6A/6B over-expression increases their sensitivity. [Cell Host Microbe] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators showed that vascular endothelial cells were the primary cellular target of sorafenib-induced hand-foot skin reaction wherein soluble heparin-binding epidermal growth factor (s-HBEGF) mediates the crosstalk between vascular endothelial cells and keratinocytes. [Cell Res] Full Article RhoJ Regulates α5β1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis The authors used vesicle purification and proteomic analysis to identify the endothelial targets of RhoJ-mediated trafficking. They identified α5β1 integrin as a major RhoJ cargo and showed that RhoJ regulated the intracellular trafficking of active α5β1 integrin in endothelial cells to repress fibronectin fibrillogenesis. [Curr Biol] Full Article | Graphical Abstract Blood Flow Limits Endothelial Cell Extrusion in the Zebrafish Dorsal Aorta Scientists dynamically record endothelial cell (EC) movements and used 3D quantitative methods to segregate the contributions of various cellular processes to the cellular trajectories in the zebrafish dorsal aorta. They found that ECs spread toward the cell extrusion area following the tissue deformation direction dictated by flow-derived mechanical forces. [Cell Rep] Full Article | Graphical Abstract Transfection of an adeno-associated virus vector named HTSFcAng(1-7) specifically increased the expression of angiotensin-(1-7) in endothelial cells in nomoxia. Hypoxia increased the expression of angiotensin-(1-7) in HTSFcAng(1-7)-transfected endothelial cells. [Mol Ther Methods Clin Dev] Abstract | Full Article | Graphical Abstract Researchers discovered that miR-590 was downregulated in gastric cancer tissues and cell lines, and this was related to the dysregulation of the transcription factor SNAIL. The overexpression of miR-590 inhibited the migration, invasion, proliferation and D-MVA levels of gastric cancer cells in vivo and in vitro by targeting VEGFR1/2 and NRP1. [Cell Death Dis] Full Article The authors showed that pristimerin affected both the early- and late-stage of angiogenesis, suggesting by that pristimerin inhibited sonic hedgehog (Shh)-induced endothelial cell proliferation, migration, invasion as well as pericytes recruitment to the endothelial tubes, which was critical for the new blood vessel maturation. [Cell Death Dis] Full Article CDDO-Me Alters the Tumor Microenvironment in Estrogen Receptor Negative Breast Cancer Investigators demonstrated that CDDO-methyl ester (CDDO-Me) significantly attenuated IL-10 and VEGF expression but stimulated TNF production, and reduced surface expression of CD206 and CD115, markers of immunosuppressive tumor associated macrophages. [Sci Rep] Full Article Scientists demonstrated that mesenchymal-endothelial transition-derived cells were highly heterogeneous and were characterized by high expression of endothelial markers such as vascular endothelial cadherin and occludin but low expression of Tek receptor tyrosine kinase, isolectin B4, endothelial nitric oxide synthase, von Willebrand factor, and CD31 after cardiac hypertrophy. [Sci Rep] Full Article Microarrays were used to track the transcriptional changes at each stage of differentiation and scientists observed that genes associated with metanephros, ureteric bud, and blood vessel development were significantly upregulated as the cells differentiated towards renal progenitors. [NPJ Regen Med] Full Article Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSRole of the Autotaxin-Lysophosphatidate Axis in the Development of Resistance to Cancer Therapy The Autotaxin-lysophosphatidate axis mediates a plethora of activities such as cell proliferation, survival, migration, angiogenesis and inflammation, which perform an important role in facilitating wound healing. [Biochim Biophys Acta] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSHarbor BioMed announced that it has received IND approval from the National Medical Products Administration in China to begin a seamless Phase II/III clinical trial to evaluate the safety and efficacy of its therapeutic antibody HBM9161 to treat adult immune thrombocytopenia. [Harbor BioMed] Press Release Intact Vascular, Inc. announced it received FDA approval for the Tack Endovascular System, a novel, minimal metal implant for precision dissection repair in the mid/distal popliteal, tibial and/or peroneal arteries. [Intact Vascular, Inc.] Press Release | |
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POLICY NEWSHow Research Funders Are Tackling Coronavirus Disruption While science is crucial to the fight against COVID-19, researchers confined to their homes and unable to carry on with grant-funded work are becoming increasingly concerned about how the coronavirus pandemic will affect their funding. [Nature News] Editorial Ending Coronavirus Lockdowns Will Be a Dangerous Process of Trial and Error After the novel coronavirus made its way from China around the world, one country after another adopted harsh measures to stop SARS-CoV-2 from spreading and overwhelming hospitals. They have hit the pause button on their economies and their citizens’ lives, stopping sports events, religious services, and other social gatherings. [ScienceInsider] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Biological Scientist – Lipid Metabolism and Dysregulation (University of FLorida) Research Associate – Cell Culturing (University of California Los Angeles Health) Postdoctoral Fellow – Precision Oncology (Weill Cornell Medicine) Research Assistant – Vascular Systems (University of Illinois at Chicago) Postdoctoral Research Fellow – Molecular Oncology (Genentech, Inc.) Postdoctoral Scientist – Gene Editing in Liver Disease (Beam Therapeutics) Research Fellow – Cardiovascular Disease (Queen’s University Belfast) Postdoctoral Researcher – Endothelial Mechanotransduction (KU Leuven) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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