Endothelial Cell News 5.16 May 4, 2020 | |
| |
TOP STORYIn coculture, type 2 diabetes-critical limb ischemia CD34+ cells imprinted naïve endothelial cells, increasing apoptosis, reducing network formation, and modulating the TUG1 sponge/miRNA-21/PDCD4 axis. [Diabetes Care] Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)cZNF532 silencing reduced the viability, proliferation, and differentiation of pericytes and suppressed the recruitment of pericytes toward endothelial cells in vitro. [J Clin Invest] Abstract | Graphical Abstract | Full Article RhoJ Integrates Attractive and Repulsive Cues in Directional Migration of Endothelial Cells During angiogenesis, VEGF acts as an attractive cue for endothelial cells (ECs), while Sema3E mediates repulsive cues. Researchers showed that the small GTPase RhoJ integrated these opposing signals in directional EC migration. [EMBO J] Abstract Investigators report that targeted loss of Id genes in adult endothelial cells resulted in dilated, leaky sinusoids and a pro-inflammatory state that increased in severity over time. [Cell Rep] Full Article | Graphical Abstract The authors investigated whether bone marrow multiple myeloma endothelial cells (MMECs) control disease progression via the junctional adhesion molecule A (JAM-A). Membrane and cytoplasmic JAM-A levels were upregulated in MMECs in 111 newly diagnosed and 201 relapsed-refractory patients compared to monoclonal gammopathy of undetermined significance and healthy controls. [Haematologica] Abstract Researchers generated inducible, endothelial cell (EC)-specific Pkd2 knockout mice to examine vascular functions of PKD2. They showed that a broad range of intravascular flow rates stimulated EC PKD2 channels, producing vasodilation. [eLife] Full Article Scientists used the specimens of cancer patients for immunohistochemical staining to observe the number of PD-L1+ CD34+ vascular endothelial cells and infiltrated immune cells inside tumor specimens. [Cell Death Dis] Full Article CXCR7 gain of function markedly promoted vasculogenesis by mesenchymal stem cells in vitro and in vivo and induced endothelial differentiation along the arterial endothelial cell lineage via upregulation of Notch signaling. [Cell Death Dis] Abstract Mouse pulmonary microvascular endothelial cells were used as a model of the microvascular endothelium and were stimulated with lipopolysaccharide. Renal function, renal inducible nitric oxide synthase (iNOS) and endothelial NOS expression, cellular apoptosis, plasma and renal levels of NO and reactive oxygen species (ROS), and phosphorylation of mitogen-activated protein kinase family members were examined. [Exp Mol Med] Full Article The authors investigated the effect of mechanical stress on the expression of angiogenic factors in porcine retinal pigment epithelial cells and determined the impact of conditioned medium on in vitro angiogenesis. [J Biol Eng] Abstract Microfluidic Synthesis of Injectable Angiogenic Microgels Scientists report a fast-gelling and angiogenic collagen scaffold interlocked by ultra-long DNA programmed with vascular endothelial growth factor aptamers. When encapsulated with cells, the angiogenic microgels improved wound healing and liver regeneration, compared with the non-angiogenic or acellular microgels. [Cell Rep Phys Sci] Full Article | Graphical Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
| |
REVIEWSNeuronal and Glial Regulation of CNS Angiogenesis and Barriergenesis The authors discuss the current understanding of how neuronal and glial development affects central nervous system (CNS) angiogenesis and barriergenesis, and outline future directions to elucidate how neuronal activity might influence these processes. [Development] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
| |
INDUSTRY NEWSREGENXBIO Inc. provided additional long-term data from the ongoing Phase I/IIa trial of RGX-314 for the treatment of wet age-related macular degeneration (wet AMD). [REGENXBIO Inc.] Press Release BioAge Labs, Inc. announced that it has entered into an exclusive worldwide license agreement with Taisho Pharmaceutical Co., Ltd. to develop and commercialize Taisho’s clinical-stage Hypoxia-inducible factor-prolyl hydroxylase (HIF-PH) inhibitor, BGE-117, to ameliorate multiple diseases of aging. [BioAge Labs, Inc. (GlobeNewswire, Inc.)] Press Release | |
| |
POLICY NEWSThe Pandemic’s Effects on Recruiting International STEM Trainees Pandemic-related concerns that have arisen for science trainees—shuttered labs, research and education delays, anxiety—are applicable across the board. But international graduate students and postdocs face a suite of unique challenges that raise uncertainty about recruiting and supporting this critical group of researchers in the future. [The Scientist] Editorial
| |
EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW PhD Student Positions – Blood Brain Barrier (Universität Leipzig) NEW Research Fellow/Scientist – Critical Limb Ischemia (National University of Ireland Galway) Postdoctoral Positions – Bioinformatics and Vascular Biology (KU Leuven and Sun Yat-Sen University) Biological Scientist – Lipid Metabolism and Dysregulation (University of Florida) Research Associate – Cell Culturing (University of California Los Angeles Health) Postdoctoral Fellow – Precision Oncology (Weill Cornell Medicine) Postdoctoral Research Fellow – Molecular Oncology (Genentech, Inc.) Postdoctoral Scientist – Gene Editing in Liver Disease (Beam Therapeutics) Research Fellow – Cardiovascular Disease (Queen’s University Belfast) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Endothelial Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|