Endothelial Cell News Volume 5.17 | May 11 2020

TOP STORY

Flow Rate Affects Nanoparticle Uptake into Endothelial Cells

A microfluidic system was developed to control the flow rates of nanoparticles as they interacted with endothelial cells. Gold nanoparticle uptake into endothelial cells was quantified at varying flow rates, and it was found that increased flow rates led to decreased nanoparticle uptake. [Adv Mater] Abstract

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Immune Modulation by Complement Receptor 3-Dependent Human Monocyte TGF-β1-Transporting Vesicles

Binding of the vesicle-transported TGF-β1 to the TGF-β receptor inhibited IL1B transcription via the SMAD7 pathway in whole blood and induced TGFB1 transcription in endothelial cells, which was resolved upon TGF-β1 inhibition. [Nat Commun] Full Article

PKCθ-JunB Axis via Upregulation of VEGFR3 Expression Mediates Hypoxia-Induced Pathological Retinal Neovascularization

Investigators studied the role of PKCθ and its downstream target genes JunB and VEGFR3 in retinal neovascularization using global and tissue-specific knockout mouse models along with molecular biological approaches. [Cell Death Dis] Full Article

NF-Kappa B Interacting Long Noncoding RNA Enhances the Warburg Effect and Angiogenesis and Is Associated with Decreased Survival of Patients with Gliomas

NF-kappa B interacting long noncoding RNA (NKILA) increased the expression level of hypoxia-inducible factor-1α, and the activity of the hypoxia pathway in gliomas. The authors demonstrated that NKILA enhanced the Warburg effect and angiogenesis in gliomas both in vitro and in vivo. [Cell Death Dis] Full Article

Cathepsin L Promotes Angiogenesis by Regulating the CDP/Cux/VEGF-D Pathway in Human Gastric Cancer

The nuclear expression levels of cathepsin L (CTSL) were assessed in gastric cancer (GC) samples. The effects of CTSL on GC angiogenesis were determined by endothelial tube formation analysis, HUVEC migration assay, and chick embryo chorioallantoic membrane assay. [Gastric Cancer] Full Article

Coumarin Derivative 7-Isopentenyloxycoumarin Induces In Vivo Anti-Tumor Activity by Inhibit Angiogenesis via CCL2 Chemokine Decrease

Researchers investigated the in vivo toxicity and the mechanism of anti-tumor action of 7-isopentenyloxycoumarin, a coumarin derivative with anti-tumor activity. The toxicity was evaluated in vitro, and in vivo. [Naunyn Schmiedebergs Arch Pharmacol] Abstract

Cyclic Strain Promotes H19 Expression and Vascular Tube Formation in iPSC-Derived Endothelial Cells

Scientists investigated expression changes of H19 resulting from mechanical stimulation during endoethelial cell (EC) differentiation, as well as functional effects on EC tube formation. Induced pluripotent stem cells (iPSCs) were subjected to 5% cyclic mechanical strain during EC differentiation. [Cell Mol Bioeng] Abstract

Comparative Study on Effect of Mesenchymal Stem Cells and Endothelial Progenitor Cells on Treatment of Experimental CCL4-Induced Liver Fibrosis

There was elevating albumin and reducing ALT concentrations in groups treated with BM-MSCs and UC-EPCs compared to untreated CCL4A&B groups. UC-EPCs treated group had significantly higher MMP-2 and VEGF genes expression than BM-MSCs treated group. [Arch Physiol Biochem] Abstract

Mycobacterium tuberculosis Cords in the Cytosol of Live Lymphatic Endothelial Cells to Evade Host Immune Surveillance

Researchers showed that several M. tuberculosis clinical isolates formed intracellular cords in primary human lymphatic endothelial cells in vitro and also in the lymph nodes of patients with tuberculosis. [JCI Insight] Abstract | Full Article | Graphical Abstract

Asynchronous Mixing of Kidney Progenitor Cells Potentiates Nephrogenesis in Organoids

Asynchronous mixing promoted nephrogenesis, and heterochronic organoids were well vascularized when engrafted under the kidney capsule. Micro-CT and injection of a circulating vascular marker demonstrated that engrafted kidney tissue was connected to the systemic circulation by two weeks after engraftment. [Commun Biol] Full Article

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Inducing Angiogenesis, a Key Step in Cancer Vascularization, and Treatment Approaches

Angiogenesis plays a crucial role in the process of tumor genesis, because solid tumor need a blood supply if they are to grow beyond a few millimeters in size. On the other hand, there is growing evidence that some solid tumor exploit existing normal blood supply and do not require a new vessel formation to grow and to undergo metastasis. [Cancers] Full Article

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PAH Trials Pausing Enrollment for COVID-19, United Therapeutic Says

United Therapeutics has temporarily stopped enrolling patients in ongoing clinical trials of treprostinil-based therapies for pulmonary arterial hypertension (PAH) amid the COVID-19 pandemic, the company announced. [United Therapeutics Corporation (BioNews Services, LLC)] Press Release

Coronavirus Blood-Clot Mystery Intensifies

Studies from the Netherlands and France suggest that clots appear in 20% to 30% of critically ill COVID-19 patients. Scientists have a few plausible hypotheses to explain the phenomenon, and they are just beginning to launch studies aimed at gaining mechanistic insights. [Nature News] Editorial

Secretive Jasons to Offer Advice on How to Reopen Academic Labs Shut by Pandemic

A group of prominent academic scientists that has been advising the US government on security matters since the Cold War is conducting a quick-turnaround, pro bono study of a new threat to national security-the impact of COVID-19 on academic research. And this time it’s personal. [ScienceInsider] Editorial

How Swamped Preprint Servers Are Blocking Bad Coronavirus Research

Repositories are rapidly disseminating crucial pandemic science- and they’re screening more closely to guard against poor-quality work. [Nature News] Editorial

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NEW Postdoctoral Researcher – Diabetic Endothelial Cell Remodeling (Aarhus University)

Postdoctoral Position – Ultrasound-Mediated Phase Transition Contrast Agents for Imaging and Therapy (University of Pittsburgh)

PhD Student Positions – Blood Brain Barrier (Universität Leipzig)

Research Fellow/Scientist – Critical Limb Ischemia (National University of Ireland Galway)

Postdoctoral Positions – Bioinformatics and Vascular Biology (KU Leuven and Sun Yat-Sen University)

Biological Scientist – Lipid Metabolism and Dysregulation (University of Florida)

Research Associate – Cell Culturing (University of California Los Angeles Health)

Postdoctoral Fellow – Precision Oncology (Weill Cornell Medicine)

Postdoctoral Researchers – Cardiovascular Disease and Cancer (Terasaki Institute for Biomedical Innovation)

Postdoctoral Research Fellow – Molecular Oncology (Genentech, Inc.)

Postdoctoral Scientist – Gene Editing in Liver Disease (Beam Therapeutics)

Postdoctoral Researchers – Pancreatic-Endothelial Cell Interactions (German Research Center for Environmental Health)

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