Endothelial Cell News 5.18 May 25, 2020 | |
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TOP STORYAtypical Cadherin FAT4 Orchestrates Lymphatic Endothelial Cell Polarity in Response to Flow Researchers identified FAT4 as a target gene of GATA-binding protein 2, a key transcriptional regulator of lymphatic vascular development and, in particular, lymphatic vessel valve development. [J Clin Invest] Full Article | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators demonstrated that perivascular stem cell-derived cyclophilin-A facilitated HIF1α-dependent angiogenesis to ameliorate compromised uterine environments in mice with Asherman’s syndrome (AS), representing the major pathophysiologic features of humans with AS. [Mol Ther] Abstract | Graphical Abstract Treatment with an antagonist targeting CXCR4, a receptor of CXCL12, inhibited chemotaxis and tube formation in endothelial cells in vitro. [Oncogene] Abstract High Glucose Mediates NLRP3 Inflammasome Activation via Upregulation of ELF3 Expression An in vitro study indicated that high glucose increased IL-1β and IL-18 expression and activated the NLRP3 inflammasome via upregulation of MARK4 in HUVECs. high glucose increased E74-like ETS transcription factor 3 (ELF3) expression. [Cell Death Dis] Full Article Omental Adipocytes Promote Peritoneal Metastasis of Gastric Cancer through the CXCL2-VEGFA Axis The authors analyzed interactions among human gastric cancer cells, endothelial cells and omental adipocytes using a 3D co-culture system. They also employed a multipronged animal study, including subcutaneous and orthotopic tumors, and humanised omental adipose tissue models. [Br J Cancer] Abstract Scientists found that the inhibitor bosutinib most potently protected against inflammation-induced endothelial barrier disruption. In vivo, bosutinib prevented lipopolysaccharide-induced alveolar protein extravasation in an acute lung injury mice model. [J Cell Sci] Abstract Researchers examined some of the cancer-specific components of extracellular vesicles-mediated tumor-vascular interactions, including the impact of genetic driver mutations and genetic instability. [Sci Rep] Full Article Neonatal rat ventricular cardiomyocytes cultured on the softer substrates displayed higher conduction velocities and improved electrophysiological properties. HUVECS formed dense networks on the sheets when co-cultured with human adipose-derived stem/stromal cells. [Sci Rep] Full Article Exosomes in endothelial progenitor cells (EPCs) were extracted and the gain-of-function study was performed to examine effects of exosomal miR-296-5p on invasion, migration, and angiogenesis of EPCs. [Clin Transl Sci] Abstract The effect of glycogen branching enzyme (GBE1) on tumor progression via changes in metabolic signaling under hypoxia in vitro and in vivo was evaluated, and GBE1-related genes from human specimens and data sets were analyzed. Hypoxia induced GBE1 upregulation in lung adenocarcinoma cells. [Signal Transduct Target Ther] Full Article A CTGF-YAP Regulatory Pathway is Essential for Angiogenesis and Barriergenesis in the Retina Scientists showed that endothelial cells (ECs) were one of the major cellular sources of connective tissue growth factor (CTGF) in the developing and adult retinal vasculature. Mice lacking CTGF expression either globally or specifically in ECs exhibited impaired vascular cell growth and morphogenesis, and blood barrier breakdown. [iScience] Abstract | Full Article | Graphical Abstract Histidine-rich glycoprotein (HRG) potently inhibited the high mobility group box-1 (HMGB1) mobilization and effectively suppressed rHMGB1-induced inflammatory responses and expression of all three HMGB1 receptors in endothelial cells. Researchers clarified that these protective effects of HRG on endothelial cells were mediated through C-type lectin domain family 1 member A (CLEC-1A) receptor. [iScience] Abstract | Full Article | Graphical Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSOne of the major challenges with most vascular regenerative therapies utilizing localized growth factor, endothelial progenitor, or genetically engineered cell delivery, is the regeneration of blood vessels with physiological compliance properties. [Int J Mol Sci] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSUofG Scientists Fast-Track Research into COVID-19 and Heart Disease University of Glasgow (UofG) researchers funded by the British Heart Foundation in Scotland are supporting global efforts to combat COVID-19 and better understand its wider effects on people with heart and circulatory diseases. [University of Glasgow] Press Release | |
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POLICY NEWSThey Redesigned PubMed, a Beloved Website. It Hasn’t Gone Over Well Unfortunately for PubMed’s caretakers, a sweeping redesign unveiled this week has left many PubMed users fuming-and airing their sometimes curse-laden complaints on social media. [ScienceInsider] Editorial Will Trump White House Tear Down Journal Paywalls? Many Anxiously Await a Decision Scientific publishers, universities, librarians, and open-access advocates are waiting anxiously to see whether the Trump administration will end a long-standing policy and require that every scholarly article produced with US funding be made immediately free to all. [ScienceInsider] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Scientist – Inflammatory Fibrosis and Endothelial Cells (The University of Pittsburgh) Postdoctoral Researcher – Diabetic Endothelial Cell Remodeling (Aarhus University) PhD Student Positions – Blood Brain Barrier (Universität Leipzig) Postdoctoral Positions – Bioinformatics and Vascular Biology (KU Leuven and Sun Yat-Sen University) Biological Scientist – Lipid Metabolism and Dysregulation (University of Florida) Postdoctoral Fellow – Precision Oncology (Weill Cornell Medicine) Postdoctoral Scientist – Gene Editing in Liver Disease (Beam Therapeutics) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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