| Vol. 5.22 – 22 June, 2020 |
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| Scientists showed that a markedly higher number of erythrocytes are accumulated in the lymphatics of cervical lymph nodes and meningeal lymphatics after subarchnoid hemorrhage. [Nature Communications] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers combined lineage tracing in a spontaneous metastatic mouse model of melanoma, advanced imaging, and single-cell RNA sequencing approaches to search for pathophysiologically relevant melanoma cellular states. [Cell Reports] |
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| Pericytes connected predominantly to other neighboring pericytes and endothelial cells, and less to arteriolar smooth muscle cells, and not to surrounding neurons or glia. [Cell Discovery] |
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| Researchers showed that LIST-printed HUVECS present negligible loss of viability and maintain their abilities to migrate, proliferate and form intercellular junctions. [Scientific Reports] |
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| Scientists employed a multicellular 3D neurovascular unit organoid containing human brain microvascular endothelial cells, pericytes, astrocytes, microglia, oligodendrocytes and neurons to model the effects of hypoxia and neuroinflammation on blood-brain barrier function. [Scientific Reports] |
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| Major Facilitator Superfamily Domain containing 2a (MFSD2A) is an essential endothelial lipid transporter at the blood-brain barrier. Researchers carried out a detailed analysis of the clinical and neuroradiological features of a series of 27 MCPH15 cases, including eight new individuals from seven unrelated families. [European Journal of Human Genetics] |
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| By using mass spectrometry combined with RNA sequencing, scientists showed that absence of P2y12 induced excessive erythropoiesis, evidenced by significantly increased expression of mature erythrocytes marker α-globin, β-globin. [Acta Pharmacologica Sinica] |
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A co-culture consisting of human adipose tissue-derived mesenchymal stem cells and HUVECs was encapsulated in the gradient construct. [Macromolecular Bioscience] |
| | Investigators evaluated rat pancreatic decellularized scaffold loaded with platelet-rich plasma for vascularization, host inflammatory response and macrophage polarization in an animal model. [Journal of Biomaterials Applications] |
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| Venous thrombotic events, particularly pulmonary embolism, with elevated D-dimer and coagulation activation are highly prevalent in COVID-19 patients. The pro-inflammatory cytokine storm, with elevated levels of interleukin-6 (IL-6), IL-2 receptor, and tumor necrosis factor-α, could also participate in endothelial dysfunction and leukocyte recruitment in the microvasculature. [Critical Care] |
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| The authors review what is known about the mechanical forces that guide endothelial cell behavior and then discuss the advancements in endothelial cell culture models designed to better mimic the in vivo vascular microenvironment. [Frontiers in Physiology] |
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| Hutchison China MediTech Limited announced that the FDA has granted Fast Track Designation for the development of fruquintinib, for the treatment of patients with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and, if RAS wild-type, an anti-epidermal growth factor receptor therapy. [Hutchison China MediTech Limited ] |
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| Bio-Thera Solutions announced that the China National Medical Products Administration (NMPA) has accepted the Biologics License Application for BAT1706, a proposed biosimilar to Avastin®. [Bio-Thera Solutions (Business Wire, Inc.)] |
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| Queen’s University Belfast – Belfast, United Kingdom |
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| The Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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| University of California, San Diego – San Diego, California, United States |
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| UC Davis – Sacramento, California, United States |
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| Spanish National Center for Cardiovascular Research – Madrid, Spain |
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| The Chinese University of Hong Kong – Hong King, China |
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| University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| Universität Leipzig – Leipzig, Germany |
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| KU Leuven and Sun Yat-Sen University – Various |
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| Beam Therapeutics – Cambridge, Massachusetts, United States |
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