 | | Vol. 5.27 – 27 July, 2020 |
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| Investigators report the transcriptional profiling of 11,868 cells in a mouse model of transplant arteriosclerosis by single-cell RNA sequencing.
[Circulation Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists assessed the impact of mitochondrial bioenergetics on neovascularisation, by deleting cox10 gene encoding an assembly factor of cytochrome c oxidase specifically in mouse endothelial cells providing a model for vasculature-restricted respiratory deficiency.
[Nature Communications] |
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| METTL3 silencing or METTL3 overexpression altered endothelial cell viability, proliferation, migration, and tube formation in vitro.
[Molecular Therapy] |
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| The authors showed that BVT-948-mediated SETD8 inhibition in HUVECs resulted in an inhibition of angiogenesis. Inhibition of SETD8 not only inhibited angiogenesis but also disrupted actin stress fiber formation and induced cell cycle arrest at S phase.
[Scientific Reports] |
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| Researchers investigated the efficacy and mechanism of the Bio 3D conduit composed of xeno-free human induced pluripotent stem cell–derived mesenchymal stem cells.
[Scientific Reports] |
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| Investigators showed that reduction of [Cl–]i inhibited HUVEC proliferation, migration, cytoskeleton reorganization, tube formation, and subsequently suppressed angiogenesis under basal condition, and VEGF stimulation or hypoxia treatment.
[Acta Pharmacologica Sinica] |
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| Scientists hypothesised that atrial fibrillation (AF) would further worsen endothelium-dependent flow-mediated dilatation in hypertension patients compared to those without AF.
[Journal of Human Hypertension] |
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| The human HEPC-CB.1 cell line with many characteristics of endothelial progenitor cells was tested for its proangiogenic properties as a potentially therapeutic compound.
[Molecular Biology Reports] |
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| The molecular characterization of lymphatic vascular development and our understanding of this vasculature’s role in pathophysiological conditions has greatly improved in recent years, changing conventional views about the roles of the lymphatic vasculature in health and disease.
[Cell] |
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| Endothelial colony‐forming cells hold significant promise as candidates for regenerative therapy of vascular injury. Existing studies remain largely preclinical and exhibit marked design heterogeneity
[Stem Cells Translational Medicine] |
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| Sarah Yuan, MD, PhD, professor and chair of the Department of Molecular Pharmacology and Physiology at the USF Health Morsani College of Medicine, has received a highly competitive National Heart, Lung, and Blood Institute Outstanding Investigator Award to continue breaking new ground in microvascular and circulation research.
[News-Medical] |
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| The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
[ScienceInsider] |
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| Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China.
[The Scientist] |
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| | October 2 – October 5 Boston, Massachusetts, United States |
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| | Technical University of Denmark – Lyngby, Denmark |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States |
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| | Universitätsklinikum Bonn – Bonn, Germany |
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| | The University of Texas Health Science Center at Houston – Houston, Texas, United States |
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