 | | Vol. 5.29 – 17 August, 2020 |
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| Researchers identified nanotube-like processes that connected two bona fide pericytes on separate capillary systems, forming a functional network in the mouse retina, which they named interpericyte tunneling nanotubes
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that in the pathological angiogenic vascular niche, retinal myeloid cells, particularly macrophages/microglia that were spatially adjacent to endothelial cells, were highly glycolytic.
[Science Translational Medicine] |
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| Genetic lineage tracing based on colony stimulating factor 1 receptor (Csf1r)-Mer-iCre-Mer showed no contribution of erythro-myeloid progenitors (EMPs) to brain endothelial cells identified by several markers. Researchers generated a knock-in mouse line by inserting an internal ribosome entry site (ires)-iCre cassette into the 3′ untranslated region of Csf1r gene to further investigate the cellular fates of EMPs.
[Circulation Research] |
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| Investigators showed that selective hyperactivation or depletion of YAP/TAZ in PDGFRβ+ intestinal stromal cells led to lacteal sprouting or regression with junctional disintegration and impaired dietary fat uptake.
[Nature Communications] |
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| The autophagy pathway was induced under prolonged hypoxia in endothelial cells, and autophagy increased angiogenic activities.
[Cell Death & Disease] |
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| Both pseudolysin and protease IV inhibited migration and survival of fibroblasts, keratinocytes, and endothelial cells. In three dimensional spheroid endothelial models and matrigel assays these proteins impeded sprouting and tube formation.
[Laboratory Investigation] |
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| Incubation of vascular endothelial cells with saturated fatty acid increased the accumulation of lipid droplets and impaired autophagic flux.
[Scientific Reports] |
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| The smooth muscles and the endothelial cells showed mild immunoreactivity to estrogen receptor alpha (ERA). Lymphocytes only exhibited strong immunoreactivity to ERA.
[Scientific Reports] |
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| Overexpression of CD146 can be observed in most of malignancies and is implicated in nearly every step of the development and progression of cancers, especially vascular and lymphatic metastasis.
[Signal Transduction and Targeted Therapy] |
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| Two interdisciplinary research teams at the University of Manitoba’s Rady Faculty of Health Sciences have received one-year grants from The Winnipeg Foundation Innovation Fund for cutting-edge projects that will advance research in the areas of brain disease and mother-infant health.
[University of Manitoba] |
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| Over the last 10 years, Dr. Adebiyi’s laboratory has focused on investigating cellular mechanisms that control vascular and kidney functions in health and disease of newborns and adults. Dr. Adebiyi recently received two new grants from the National Institutes of Health (NIH) to support these research initiatives.
[University of Tennessee (EurekaAlert!)] |
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| October 2 – October 5
Boston, Massachusetts, United States |
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| | University of California, Davis – Davis, California, United States |
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| | United Therapeutics – Silver Spring, Maryland, United States |
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| | Technical University of Denmark – Lyngby, Denmark |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | Beth Israel Deaconess Medical Center – Boston, Massachusetts, United States |
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