Endothelial Cell News Volume 5.30 | August 24 2020

    0
    39







    ENDO Volume 5.30 | August 24


    Endothelial Cell News by STEMCELL Technologies
    Vol. 5.30 – 24 August, 2020
    TOP STORY

    Design of a Small Molecule That Stimulates Vascular Endothelial Growth Factor a Enabled by Screening RNA Fold–Small Molecule Interactions

    Researchers report the design of a small molecule that specifically and potently enhanced VEGFA expression by the targeting of a non-coding microRNA that regulates its expression.
    [Nature Chemistry]

    AbstractGraphical Abstract

    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    PUBLICATIONSRanked by the impact factor of the journal

    Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome

    Investigators identified a developmentally impaired endocardial population in hypoplastic left heart syndrome through single-cell RNA profiling of hiPSC-derived endocardium and human fetal heart tissue with an underdeveloped left ventricle.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    The Angiocrine Rspondin3 Instructs Interstitial Macrophage Transition via Metabolic–Epigenetic Reprogramming and Resolves Inflammatory Injury

    The authors found that, in response to inflammatory injury, lung endothelial cells released the Wnt signaling modulator Rspondin3, which activated β-catenin signaling in lung interstitial macrophages and increased mitochondrial respiration by glutaminolysis.
    [Nature Immunology]

    Full Article

    Piezo1-Mediated Ca2+ Activities Regulate Brain Vascular Pathfinding during Development

    Invesigators report that Piezo1-mediated Ca2+ activities at primary branches of endothelial tip cells (ETCs) regulated branch dynamics to accomplish ETC pathfinding during zebrafish brain vascular development.
    [Neuron]

    AbstractGraphical Abstract

    IL-6 Trans-Signaling Induces Plasminogen Activator Inhibitor-1 from Vascular Endothelial Cells in Cytokine Release Syndrome

    In vitro data indicated that endothelial IL-6 trans-signaling formed an inflammation circuit for robust IL-6, IL-8, and MCP-1 production and promoted plasminogen activator inhibitor-1 production; additionally, an IL-6 signaling blockade by the human monoclonal antibody tocilizumab blunted endothelial cell activation.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    ApoC1 Promotes the Metastasis of Clear Cell Renal Cell Carcinoma via Activation of STAT3

    ApoC1 in the exosomes were transferred from the clear cell renal cell carcinoma cells (ccRCC) to the vascular endothelial cells and promoted metastasis of the ccRCC via activating STAT3.
    [Oncogene]

    Abstract

    Disrupted Endothelial Cell Heterogeneity and Network Organization Impair Vascular Function in Prediabetic Obesity

    Small artery diameter recordings confirmed nitric-oxide mediated vasodilator responses were dependent on increases in endothelial calcium levels and were impaired in obese animals.
    [Metabolism]

    Abstract
    Full Article

    Circulating Endothelial Cells as a Marker of Endothelial Injury in Severe COVID -19

    99 patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher circulating endothelial cells counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines.
    [Journal of infectious Diseases]

    AbstractFull Article

    Acidosis Induces Synovial Fibroblasts to Release Vascular Endothelial Growth Factor via Acid-Sensitive Ion Channel 1a

    Scientists investigated the role of tissue acidification in microvascular formation of arthritic synovial tissue and the effect of acid-sensitive ion channel 1 on vascular endothelial growth factor release from arthritic synovial tissue.
    [Laboratory Investigation]

    Abstract

    Autophagy Protein ATG7 Is a Critical Regulator of Endothelial Cell Inflammation and Permeability

    Researchers investigated the role of ATG7, an essential autophagy regulator with no autophagy-unrelated functions, in the mechanism of endothelial cell inflammation and permeability.
    [Scientific Reports]

    Full Article

    Morphological Landscape of Endothelial Cell Networks Reveals a Functional Role of Glutamate Receptors in Angiogenesis

    The authors developed a high content analysis framework for detailed quantification of various aspects of network morphology including network complexity, symmetry and topology.
    [Scientific Reports]

    Full Article

    Five tips for returning to the lab after time off
    REVIEWS

    Challenges and Novel Therapies for Vascular Access in Haemodialysis

    The high morbidity and mortality associated with current vascular access complications highlights an unmet clinical need for novel techniques in vascular access and is driving innovation in vascular access care.
    [Nature Reviews Nephrology]

    Abstract

    The Role of Statins in the Prevention of Preeclampsia

    Pravastatin has been shown in various preclinical and clinical studies to reverse the pregnancy-specific angiogenic imbalance associated with preeclampsia, to restore global endothelial health, and to prevent oxidative and inflammatory injury.
    [American Journal of Obstetrics and Gynecology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Opthea Completes Successful Meetings with FDA and EMA for OPT-302 Phase III Clinical Program in Wet AMD

    Opthea Limited announced that it has successfully completed End-of-Phase II meetings with the FDA, and a Scientific Advice meeting with the European Medicines Agency (EMA), to obtain guidance on the Phase III clinical development plans of OPT-302 as a treatment for neovascular age-related macular degeneration (wet AMD).
    [Opthea Limited (GlobeNewswire, Inc.)]

    Press Release

    Exelixis Announces Submission of Supplemental New Drug Application to US Food and Drug Administration for CABOMETYX® (Cabozantinib) in Combination with Opdivo® (Nivolumab) for Advanced Renal Cell Carcinoma

    Exelixis, Inc. announced the submission of a supplemental New Drug Application to the FDA for CABOMETYX® in combination with Opdivo® for patients with advanced renal cell carcinoma.
    [Exelixis, Inc.]

    Press Release

    FEATURED EVENT

    Vascular Biology 2020

    October 26, 2020
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Xenotransplantation Products

    eGenesis Bio – Cambridge, Massachusetts, United States

    Project Scientist – Cardiovascular Research

    University of California, Davis – Davis, California, United States

    Intern – Regenerative Medicine in Pulmonary Hypertension

    United Therapeutics – Silver Spring, Maryland, United States

    Postdoctoral Scholarship – Endothelial Cells in Diabetic Retinopathy

    Technical University of Denmark – Lyngby, Denmark

    Postdoctoral Position – Cardiovascular and Cardiomyopathy Research

    Albert Einstein College of Medicine – New York, New York, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Science News Endothelial Cell News Archives Contact Us
    Endothelial Cell News Twitter