| Vol. 5.30 – 24 August, 2020 |
| |
|
|
| Researchers report the design of a small molecule that specifically and potently enhanced VEGFA expression by the targeting of a non-coding microRNA that regulates its expression. [Nature Chemistry] |
| |
|
|
PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Investigators identified a developmentally impaired endocardial population in hypoplastic left heart syndrome through single-cell RNA profiling of hiPSC-derived endocardium and human fetal heart tissue with an underdeveloped left ventricle. [Cell Stem Cell] |
|
|
|
| The authors found that, in response to inflammatory injury, lung endothelial cells released the Wnt signaling modulator Rspondin3, which activated β-catenin signaling in lung interstitial macrophages and increased mitochondrial respiration by glutaminolysis. [Nature Immunology] |
|
|
|
| Invesigators report that Piezo1-mediated Ca2+ activities at primary branches of endothelial tip cells (ETCs) regulated branch dynamics to accomplish ETC pathfinding during zebrafish brain vascular development. [Neuron] |
|
|
|
| In vitro data indicated that endothelial IL-6 trans-signaling formed an inflammation circuit for robust IL-6, IL-8, and MCP-1 production and promoted plasminogen activator inhibitor-1 production; additionally, an IL-6 signaling blockade by the human monoclonal antibody tocilizumab blunted endothelial cell activation. [Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| ApoC1 in the exosomes were transferred from the clear cell renal cell carcinoma cells (ccRCC) to the vascular endothelial cells and promoted metastasis of the ccRCC via activating STAT3. [Oncogene] |
|
|
|
| Small artery diameter recordings confirmed nitric-oxide mediated vasodilator responses were dependent on increases in endothelial calcium levels and were impaired in obese animals. [Metabolism] |
|
|
|
| 99 patients with COVID-19 were enrolled in this retrospective study. Patients in the intensive care units (ICU) had significantly higher circulating endothelial cells counts than non-ICU patients and the extent of endothelial injury was correlated with putative markers of disease severity and inflammatory cytokines. [Journal of infectious Diseases] |
|
|
|
| Scientists investigated the role of tissue acidification in microvascular formation of arthritic synovial tissue and the effect of acid-sensitive ion channel 1 on vascular endothelial growth factor release from arthritic synovial tissue. [Laboratory Investigation] |
|
|
|
| Researchers investigated the role of ATG7, an essential autophagy regulator with no autophagy-unrelated functions, in the mechanism of endothelial cell inflammation and permeability. [Scientific Reports] |
|
|
|
| The authors developed a high content analysis framework for detailed quantification of various aspects of network morphology including network complexity, symmetry and topology. [Scientific Reports] |
| |
|
|
|
| The high morbidity and mortality associated with current vascular access complications highlights an unmet clinical need for novel techniques in vascular access and is driving innovation in vascular access care. [Nature Reviews Nephrology] |
|
|
|
| Pravastatin has been shown in various preclinical and clinical studies to reverse the pregnancy-specific angiogenic imbalance associated with preeclampsia, to restore global endothelial health, and to prevent oxidative and inflammatory injury. [American Journal of Obstetrics and Gynecology] |
|
|
|
|
| Opthea Limited announced that it has successfully completed End-of-Phase II meetings with the FDA, and a Scientific Advice meeting with the European Medicines Agency (EMA), to obtain guidance on the Phase III clinical development plans of OPT-302 as a treatment for neovascular age-related macular degeneration (wet AMD). [Opthea Limited (GlobeNewswire, Inc.)] |
|
|
|
| Exelixis, Inc. announced the submission of a supplemental New Drug Application to the FDA for CABOMETYX® in combination with Opdivo® for patients with advanced renal cell carcinoma. [Exelixis, Inc.] |
|
|
|
|
|
|
|
| eGenesis Bio – Cambridge, Massachusetts, United States |
|
|
|
| University of California, Davis – Davis, California, United States |
|
|
|
| United Therapeutics – Silver Spring, Maryland, United States |
|
|
|
| Technical University of Denmark – Lyngby, Denmark |
|
|
|
| Albert Einstein College of Medicine – New York, New York, United States |
|
|
|
|