Endothelial Cell News Volume 5.31 | August 31 2020

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    Justin.choi
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    2020-08-31 | ENDOCN 5.31


    Endothelial Cell News by STEMCELL Technologies
    Vol. 5.31 – 31 August, 2020
    TOP STORY

    Shaping Waves of Bone Morphogenetic Protein Inhibition during Vascular Growth

    Oscillations in the expression of matrix Gla protein and Crossveinless-2 were detected in endothelial cells in vitro, using qPCR and immunoblotting.
    [Circulation Research]

    Abstract

    Virtual Conference Exhibition: Pluripotent Stem Cells
    PUBLICATIONSRanked by the impact factor of the journal

    Differentiation of Human Intestinal Organoids with Endogenous Vascular Endothelial Cells

    Given that endothelial cells (ECs) possess organ-specific gene expression, morphology, and function, investigators used bulk RNA-seq and scRNA-seq to interrogate the developing human intestine, lung, and kidney in order to identify organ-enriched EC gene signatures.
    [Developmental Cell]

    AbstractGraphical Abstract

    Hypoxic Tumor-Derived Exosomal Long Noncoding RNA UCA1 Promotes Angiogenesis via miR-96-5p/AMOTL2 in Pancreatic Cancer

    Scientists observed that hypoxic exosomes derived from pancreatic cancer cells promoted cell migration and tube formation of human umbilical vein endothelial cells.
    [Molecular Therapy-Nucleic Acids]

    AbstractGraphical Abstract

    Global Transcriptional Downregulation of TREX and Nuclear Trafficking Machinery as Pan-Senescence Phenomena: Evidence from Human Cells and Tissues

    A gene set-based approach using 25 different studies showed that the TREX-NCT gene set displayed distinct common downregulated patterns in senescent cells versus its expression in their nonsenescent counterparts regardless of the senescence type.
    [Experimental and Molecular Medicine]

    Full Article

    Assessing Hemorrhage-Critical Values of Cerebral Blood Flow by Modelling Biomechanical Stresses on Capillaries in the Immature Brain

    The properties of the endothelial cells and basement membranes employed were selected on the basis of published nanoindentation measurements using atomic force microscopes.
    [Scientific Reports]

    Full Article

    Celastrol Dilates and Counteracts Ethanol-Induced Constriction of Cerebral Arteries

    Current data demonstrated that celastrol dilated de-endothelialized, ex vivo pressurized middle cerebral arteries from rats with EC50=45 µM and Emax=100 µM, with MCA diameter reaching a 10% increase over vehicle-containing, time-matched value. A similar vasodilatory efficacy was achieved when celastrol was probed on middle cerebral arteries segments with intact endothelium.
    [Journal of Pharmacology and Experimental Therapeutics]

    Full Article

    Ruscogenin Attenuates Particulate Matter-Induced Acute Lung Injury in Mice via Protecting Pulmonary Endothelial Barrier and Inhibiting TLR4 Signaling Pathway

    The authors investigated whether and how ruscogenin (RUS) exerted therapeutic effects on particular matter-induced acute lung injury. RUS was orally administered to mice prior to or after intratracheal instillation of particulate matter suspension.
    [Acta Pharmacologica Sinica]

    Abstract

    Fentanyl Stimulates Tumor Angiogenesis via Activating Multiple Pro-Angiogenic Signaling Pathways

    Investigators found that fentanyl at nanomolar concentrations significantly stimulated capillary network formation of human lung tumor-associated endothelial cell (HLT-EC) in a similar manner as VEGF and furthermore that the stimulatory effect of fentanyl was mainly involved in early stage of HLT-EC vascular structure assembly.
    [Biochemical and Biophysical Research]

    Abstract

    Watch 'collaborating to accelerate COVID-19 research'
    REVIEWS

    It Takes Two to Tango: Endothelial TGFβ/BMP Signaling Crosstalk with Mechanobiology

    The authors summarize the current literature on crosstalk mechanisms between biochemical cues elicited by TGFβ/bone morphogenic protein growth factors and mechanical cues, as shear stress or matrix stiffness that collectively orchestrated endothelial function.
    [Cells]

    Full ArticleGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Seneca Therapeutics, Inc. Licenses Tumor Endothelial Marker 8 (TEM8) to Enable Better Patient Selection for SVV-001 Therapy

    Seneca Therapeutics, Inc., announced the company has licensed TEM 8 intellectual property from the Memorial Sloan Kettering Cancer Center. TEM8 may enable pre-screening of solid tumors to determine if SVV-001 might be effective in that patient.
    [Seneca Therapeutics, Inc. (BusinessWire, Inc.)]

    Press Release

    Indee Labs Awarded Grant from the National Institute of Allergy and Infectious Diseases

    Indee Labs is a biotechnology company developing the µVS Delivery SystemTM for non-viral intracellular or gene delivery. The team at Indee Labs was awarded a grant from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, to develop the µVS Delivery SystemTM for modified regulatory T cells.
    [Indee Labs (BusinessWire, Inc.)]

    Press Release

    Alimera Sciences Announces National Reimbursement Granted for ILUVIEN®
     in the Netherlands

    Alimera Sciences, Inc. announced that Alimera Sciences Europe Limited, its Ireland-based European subsidiary received an add-on status for the pricing and reimbursement approval for ILUVIEN® in the Netherlands from the Ministry of Health, effective September 1, 2020.
    [Alimera Sciences, Inc.]

    Press Release

    FEATURED EVENT

    Vascular Biology 2020

    October 26, 2020
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Project Scientist – Division of Cardiovascular Medicine

    University of California, Davis – Davis, California, United States


    Research Associate – Xenotransplantation Products

    eGenesis Bio – Cambridge, Massachusetts, United States

    Project Scientist – Cardiovascular Research

    University of California, Davis – Davis, California, United States

    Intern – Regenerative Medicine in Pulmonary Hypertension

    United Therapeutics – Silver Spring, Maryland, United States

    Postdoctoral Scholarship – Endothelial Cells in Diabetic Retinopathy

    Technical University of Denmark – Lyngby, Denmark

    > See All Jobs

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