 | | Vol. 5.34 – 28 September, 2020 |
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| The hepatocellular carcinoma ecosystem displayed features reminiscent of fetal development, including re-emergence of fetal-associated endothelial cells and fetal-like tumor-associated macrophages.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that the nitric oxide synthase (NOS)-like nanoplatform (NanoNOS) greatly suppressed injury-driven monocyte-endothelial cell adhesion, suggesting NanoNOS treatment could help prevent cardiovascular diseases.
[ACS Nano] |
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| Blood outgrowth endothelial cells from idiopathic pulmonary artery hypertension patients were used to determine the impact of HIF2α-inhibition on endothelial function.
[European Respiratory Journal] |
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| Endothelial calmodulin, a key calcium signaling protein, interacts with the IQ domain of IQGAP1, which is localized to endothelial junctions and is required for leukocyte transendothelial migration.
[Journal of Experimental Medicine] |
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| Scientists utilized single-cell transcriptomics to systematically map the cell-type-specific gene expression in a chemotherapy-resistant osteosarcoma tumor.
[Signal Transduction and Targeted Therapy] |
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| Inspired by the human placenta, scientists established a coculture of a trophoblast- derived cell line, together with primary placental fibroblasts within the biological membrane and primary human placental endothelial cells- representing three cellular components of the human placental villus.
[Scientific Reports] |
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| Investigators demonstrated that immunoglobulin and proline-rich receptor-1 (IGPR-1) was activated by autophagy-inducing stimuli, such as amino acid starvation, nutrient deprivation, rapamycin and lipopolysaccharide.
[Journal of Biological Chemistry] |
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| Researchers demonstrated that shear stress‐induced sensitization is brief and can be impaired when exposing aortic endothelial cells to low and proatherogenic levels of shear stress.
[Journal of Cellular Physiology] |
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| WNT–β-catenin signaling is involved in chronic kidney disease-associated vascular calcification and mineral bone disease. The WNT–β-catenin pathway is tightly regulated, for example, by proteins of the Dickkopf family.
[Nature Reviews Nephrology] |
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| Scientists analyze and described the possible mechanisms causative of brain injury after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. They propose that potential routes of SARS-CoV-2 neuro-invasion are determinant factors in the process.
[Molecular Neurobiology] |
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| The authors present an objective review of the key senescence-related alterations of the major intracellular organelles and analyze the role of relevant cell types for senescence and atherogenesis.
[Cells] |
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| Morphic Therapeutic announced that the first healthy volunteers have received MORF-057 in a Phase I clinical trial designed to evaluate MORF-057’s safety and pharmacokinetic profile in addition to predictive pharmacodynamic signals. MORF-057 is in clinical development as an oral small molecule inhibitor of the α4β7 integrin for the treatment of inflammatory bowel disease with an initial focus on ulcerative colitis.
[Morphic Therapeutic] |
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| Zhittya Genesis Medicine, Inc. announced that it will initiate clinical trials to test a medical hypothesis that has been advanced over the last five years that Parkinson’s disease may be caused by vascular disruption in the areas of the brain which house the “dopamine-producing neurons”, those neurons which become dysfunctional in patients suffering from this disorder.
[Zhittya Genesis Medicine, Inc. (GlobeNewswire, Inc.)] |
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| October 26- October 29, 2020
Virtual |
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| | Wellcome Sanger Institute – Cambridge, England, United Kingdom |
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| | Purdue University – West Lafayette, Indiana, United States |
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| | Miller School of Medicine – Miami, Florida, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | United Therapeutics – Silver Spring, Maryland, United States |
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