| Vol. 5.35 – 5 October, 2020 |
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| Scientists used mouse models of breast and lung cancer to investigate whether endothelial cells also have active ‘instructive’ roles in the dissemination of cancer. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| HUVECs or human coronary artery endothelial cells were pre-treated with the antiretrovirals abacavir sulphate, tenofovir disoproxil fumarate or tenofovir alafenamide. [Circulation Research] |
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| Researchers demonstrated that heparan sulfate glycosaminoglycans (HS GAGs) regulate angiopoietin (Ang)–Tie signaling through direct interactions with both Ang ligands and Tie1 receptors. HS GAGs formed ternary complexes with Ang1 or Ang4 and Tie2 receptors, resulting in potentiation of endothelial survival signaling. [Nature Chemical Biology] |
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| Endothelial calmodulin, a key calcium signaling protein, interacts with the IQ domain of IQGAP1, which is localized to endothelial junctions and is required for leukocyte transendothelial migration. [Journal of Experimental Medicine] |
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| Investigators showed that a subpopulation of angiogenic endothelial cells was induced in the brain in patients with Alzheimer’s disease. These angiogenic endothelial cells exhibited increased expression of angiogenic growth factors and their receptors and antigen-presentation machinery. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers found that surface VEGFR-2 could be mobile or exhibit restricted mobility and be monomeric or non-monomeric, with a complex interplay between the two. [Cell Reports] |
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| Prior to extrusion, the innermost cell encapsulating hydrogel was loaded with HUVECs, whereas the outer hydrogel was loaded with human aortic smooth muscle cells. [Biofabrication] |
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| Scientists identified a novel circRNA, circ_2858, that was significantly upregulated in human brain microvascular endothelial cells upon meningitic E. coli infection. [Molecular Therapy-Nucleic Acids] |
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| To illuminate the effects and elucidate the mechanisms of P. gingivalis on endothelial structural integrity, investigators developed P. gingivalis infection models in vivo and in vitro. [International Journal of Oral Science] |
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| Tuning the traction and intercellular forces using different topographic geometries of symmetric and asymmetric ring-shape patterns regulated the vascular asymmetric morphogenesis in vitro. [Biophysical Journal] |
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| Investigators report an electronic blood vessel, with excellent biocompatibility, flexibility, mechanical strength, and degradability, that could enable in situ electrical stimulation and electroporation and exhibit excellent patency in a rabbit model. [Matter] |
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| While respiratory symptoms are the major clinical manifestations, cardiovascular abnormalities, including arrhythmias, myocarditis, heart failure, and ischemic stroke, have been reported in a significant number of COVID-19 patients. [Acta Pharmacologica Sinica] |
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| The authors review recent findings describing new origins of lymphatic endothelial cells during embryonic development and discuss their relevance to cancer lymphangiogenesis. [Frontiers in Physiology] |
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| Ocular Therapeutix™, Inc. announced that it has dosed the first patients in its Phase II clinical trial of OTX-CSI for the treatment of dry eye disease. [Ocular Therapeutix™, Inc.] |
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| Eyevensys announced the FDA has granted an orphan-drug designation for EYS611 for the treatment of retinitis pigmentosa. [Eyevensys] |
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| November 2 – November 3 Virtual |
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| Wellcome Sanger Institute – Cambridge, England, United Kingdom |
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| Purdue University – West Lafayette, Indiana, United States |
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| Miller School of Medicine – Miami, Florida, United States |
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| The University of British Columbia – Vancouver, British Columbia, Canada |
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| United Therapeutics – Silver Spring, Maryland, United States |
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