 | | Vol. 5.36 – 19 October, 2020 |
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| Investigators used single-cell analysis to elucidate the cell types, development, renewal and evolution of the alveolar capillary endothelium. They showed that alveolar capillaries were mosaics; similar to the epithelium that lines the alveolus, the alveolar endothelium was made up of two intermingled cell types, with complex ‘Swiss-cheese’-like morphologies and distinct functions.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Reserchers tested whether environmental stress could induce cellular dysfunction through modulating RNA-chromatin interactions. They induced endothelial cell dysfunction with high glucose and TNFα, that mimiced the common stress in diabetes mellitus.
[Nature Communications] |
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| When GCSDL contacted with tumor vascular endothelial cells, the overexpressed γ‐glutamyltranspeptidase enzyme on cytomembrane catalyzed the hydrolysis of glutathione to generate cationic primary amines.
[Small] |
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| Scientists used a knock-in mouse line, a genetic model for breast cancer and metastasis, a syngeneic melanoma lung colonization model, and orthotopic injection of E0771 breast cancer cells to show that alternative forms increased the diversity of Angiopoietin-2 function.
[Cancer Research] |
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| Researchers showed that nascent blood vessels actively contacted dividing neural stem cells by endothelial filopodia in the ventricular zone (VZ) of the murine ventral telencephalon; this association was conserved in the human ventral VZ.
[Cell Reports] |
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| The authors determined whether restoring diabetes-inhibited BMP4 expression in Flk-1+ progenitors effectively prevented maternal diabetes-induced embryonic vasculopathy and neural tube defects.
[Cell Death & Disease] |
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| Scientists examined the effects of evogliptin, a potent dipeptidyl peptidase-4 inhibitor, on pathological retinal neovascularization in mice and elucidated the mechanism by which evogliptin inhibits angiogenesis mediated by VEGF, a key factor in the vascular pathogenesis of proliferative diabetic retinopathy
[Experimental and Molecular Medicine] |
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| Amphiphilic derivatives of poly-N-vinylpyrrolidone nanoparticles (Amph-PVP NPs) and fluorescently labeled Amph-PVP-based NPs, namely “PVP” NPs and “F”-NPs, were synthesized to study Amph-PVP NPs interactions with HMEC-1 endothelial cells.
[Molecular Pharmaceutics] |
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| Researchers examined the pro-angiogenic effect of N-NAM using human umbilical vein endothelial cells and the rat middle cerebral artery occlusion model of stroke.
[Scientific Reports] |
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| Hypoxia and/or co-culture with multiple myeloma (MM) cells significantly increased vascular endothelial growth factor (Vegf)-a expression in MLOA5-Ocys, and conditioned media (CM) from MLOA5s or MM-MLOA5 co-cultured in hypoxia, significantly increased endothelial tube length compared to normoxic CM.
[Scientific Reports] |
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| To identify the active paracrine factors released by macrophages in response to stimulation by mesenchymal stem cell (MSC) conditioned media, scientists used an antibody array; identifying increased expression of the angiogenesis-related proteins stromal cell-derived factor 1 and plasminogen activator inhibitor-1. Knockdown of either protein inhibited the ability of conditioned media derived from MSC paracrine factor stimulated macrophages to induce endothelial cell differentiation both in vitro and in vivo.
[American
Journal of Physiology-Cell Physiology] |
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| Investigators used human induced pluripotent stem cell (hiPSC)-derived endothelial cells (ECs) and bulk- and single-cell RNA sequencing to study the effect of flow on the transcriptomic landscape of hiPSC-ECs and their heterogeneity.
[Frontiers in Physiology] |
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| The authors present current evidence from human and animal studies on integrin structure and molecular signaling, with particular emphasis on signal transduction in infants.
[Pediatric Research] |
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| Thomas Longden, PhD, assistant professor in the Department of Physiology at the University of Maryland School of Medicine, has received the National Institutes of Health (NIH) Director’s New Innovator Award. The award provides $2.3 million to support an “exceptionally creative early career investigator” as part of the High-Risk, High-Reward Research Program of the NIH Common Fund.
[University of Maryland Baltimore] |
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| January 9 – January 12, 2021
Lake Buena Vista, Florida, United States |
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| | Technical University of Denmark – Lyngby, Denmark |
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| | Wellcome Sanger Institute – Cambridge, England, United Kingdom |
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| | Purdue University – West Lafayette, Indiana, United States |
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| | Purdue University – West Lafayette, Indiana, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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