 | | Vol. 5.40 – 16 November, 2020 |
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| An anti‐inflammatory gene therapy nanoparticle targeted to VCAM‐1, a protein overexpressed by inflamed endothelial cells located within atherosclerotic plaque, was developed.
[Advanced Therapeutics] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| In this study, a novel type of injectable hydrogel with dual functions of reactive oxygen species scavenging and O2 generating is fabricated for myocardial infarction treatment in vivo.
[Small] |
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| Endothelial cells were isolated from human brain and analyzed by RNA sequencing. Human umbilical vein and human brain microvascular cells were used in both monolayer culture and endothelialized within a 3-dimensional printed vascular model of the middle cerebral artery.
[Stroke] |
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| Investigators designed and tested new endothelial differentiation media with a fully defined composition using standard basal culture media supplemented with a mixture of B27, heparin and growth factors, including VEGF-A165 at different concentrations.
[Biomedicines] |
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| The CARD8 mRNA was knocked-down in HUVECs in vitro, followed by quantitative RT-PCR analysis and OLINK Proteomics. Endothelial and smooth muscle cells in arterial tissue expressed CARD8 and CARD8 correlated with vWF, CD163 and the expression of inflammatory genes, such as CXCL1, CXCL6 and PDGF-A in plaque.
[Scientific Reports] |
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| Proteomic analyses of human angiogenesis-related factors produced by human adipose tissue-derived stromal/stem cells (hADSCs) showed that both pro- and anti-angiogenic factors were produced by hADSCs in vitro, but only those related to vessel maturation were detectable in vivo.
[Scientific Reports] |
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| Cellular uptake and monolayer permeability of atorvastatin, pravastatin, and rosuvastatin were investigated, in vitro, using HUVECs.
[Journal of Pharmacology and Experimental Therapeutics] |
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| Mice were subjected to exercise training for four weeks. Bone marrow-derived endothelial progenitor cells (EPCs) were isolated and cultured in vitro. Exercise upregulated miR-126 expression but downregulated the protein levels of its target gene, Spred1, in EPCs from myocardial infarctionmice.
[Experimental Cell Research] |
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| Researchers explored the pathogenesis of diabetic retinopathand identified new treatments that can provide dual-target intervention for angiogenesis and fibrosis. They explored changes in gene expression in high glucose–induced vascular endothelial cells using RNA sequencing technology.
[International Journal of Molecular Medicine] |
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| The authors explore the relationship between endothelial cells and vascular calcification and to provide a theoretical basis and new ideas for the active prevention and treatment of vascular calcification in the clinic.
[Microvascular Research] |
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| Apollomics, Inc. announced that APL-102 has received China Investigational New Drug approval from the Center for Drug Evaluation of the National Medical Products Administration for the initiation of a Phase I pharmacokinetic and tolerability study of APL-102 in patients with advanced solid tumors.
[Apollomics, Inc.] |
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| April 11 – April 13, 2021
San Diego, California, United States |
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| | Stanford University – Stanford, California, United States |
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| | Novo Nordisk A/S – Copenhagen, Denmark |
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| | Universität Leipzig – Leipzig, Germany |
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| | The University of Sheffield – Sheffield, England, United Kingdom |
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| | Purdue University – West Lafayette, Indiana, United States |
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