Endothelial Cell News Volume 5.41 | Nov 23 2020

May 12, 2022

2020-10-23 | ENDOCN 5.41

Endothelial Cell News by STEMCELL Technologies

Vol. 5.41 – 23 November, 2020

TOP STORY

Macrophage
Expression and Prognostic Significance of the Long Pentraxin PTX3 in COVID-19

RNA-sequencing analysis of peripheral blood mononuclear cells, single-cell bioinformatics analysis and immunohistochemistry of lung autopsy samples revealed that myelomonocytic cells and endothelial cells expressed high levels of PTX3 in patients with COVID-19.
[Nature Immunology]

Full Article

View-On-Demand Webinar: Therapeutic Application of Endothelial Colony-Forming Cells. Watch Now.

PUBLICATIONSRanked by the impact factor of the journal

RIPK1
Expression Associates with Inflammation in Early Atherosclerosis in Humans and Can be Therapeutically Silenced to Reduce NF-κB Activation and Atherogenesis in Mice

Researchers examined expression of RIPK1 protein and mRNA in both human and mouse atherosclerotic lesions, and using loss-of-function approaches in vitro in macrophages and endothelial cells to measure inflammatory responses. They administered weekly injections of RIPK1 anti-sense oligonucleotides to Apoe^-/- mice fed a cholesterol-rich diet for eight weeks.
[Circulation]

Abstract

Decreased
Blood Vessel Density and Endothelial Cell Subset Dynamics during Aging of the Endocrine System

Angiogenesis and β‐cell expansion in the pancreas were coupled by a distinct age‐dependent subset of endothelial cells (ECs). While this EC subpopulation supported pancreatic β cells, it declined during aging concomitant with increased expression of the gap junction protein Gja1.
[EMBO Journal]

Full Article Graphical Abstract

LncRNA
MYLK-AS1 Facilitates Tumor Progression and Angiogenesis by Targeting miR-424-5p/E2F7 Axis and Activating VEGFR-2 Signaling Pathway in Hepatocellular Carcinoma

Human HCC cell lines were used to evaluate the colony formation, cell proliferation, migration, invasion, cell cycle and apoptosis after transfection of lentiviral short-hairpin RNAs targeting MYLK-AS1 or MYLK-AS1 vectors.
[Journal of Experimental & Clinical Cancer Research]

Full Article

Human
Adipose-Derived Stem Cells Enriched with VEGF-Modified mRNA Promote Angiogenesis and Long-Term Graft Survival in a Fat Graft Transplantation Model

Human adipose-derived stem cells were acquired from lipoaspiration and transfected with modRNAs. Transfection efficiency and expression kinetics of modRNAs in hADSCs were first evaluated in vitro.
[Stem Cell Research & Therapy]

Full Article

Coadministration
of Endothelial and Smooth Muscle Cells Derived from Human Induced Pluripotent Stem Cells as a Therapy for Critical Limb Ischemia

Investigators explored the therapeutic efficacy of human induced pluripotent stem cell (iPSC)‐derived endothelial cell and iPSC‐derived smooth muscle cell in peripheral artery disease model.
[Stem Cells Translational Medicine]

Full Article

Blood-Derived
Extracellular Vesicles Isolated from Healthy Donors Exposed to Air Pollution Modulate In Vitro Endothelial Cells Behavior

The authors investigated the ability to activate endothelial primary cells by plasmatic extracellular vesicles (EVs) after both high and low particular matter (PM) exposure. Normal weight-high-PM EVs showed an increased endothelial activation, measured as CD105⁺/CD62e⁺ EVs ratio.
[Scientific Reports]

Full Article

In Vitro Modeling of Solid Tumor Interactions with Perfused Blood Vessels

Researchers introduced a microfluidic model of the solid tumor-vascular interface composed of a human umbilical vein endothelial cell (HUVEC)-lined, perfusable, bioengineered blood vessel and tumor spheroids embedded in an extracellular matrix.
[Scientific Reports]

Full Article

Interleukin-8
Receptors CXCR1 and CXCR2 Are Not Expressed by Endothelial Colony-Forming Cells

CXCR1 and CXCR2 were not detected on several clones of cord blood- endothelial colony-forming cell using different antibodies available, in contrast to well-known positive cells.
[Stem Cell Reviews and Reports]

Abstract Graphical Abstract

Paracrine
Effect of Human Adipose-Derived Stem Cells on Lymphatic Endothelial Cells

Investigators evaluated, in vitro, the potential paracrine effect of human adipose-derived stem cells to promote lymphangiogenesis in lymphatic endothelial cells isolated from rat diaphragmatic lymphatic vessels.
[Regenerative Medicine]

Full Article

Derive and expand human endothelial cells with EC-Cult™-XF Culture Kit.

REVIEWS

Thrombocytopathy
and Endotheliopathy: Crucial Contributors to COVID-19 Thromboinflammation

The authors summarize new lines of evidence that point to both platelet and endothelial dysfunction as essential components of COVID-19 pathology and describe the mechanisms that might account for the contribution of cardiovascular risk factors to the most severe outcomes in COVID-19.
[Nature Reviews Cardiology]

Full Article

INDUSTRY AND POLICY NEWS

Samsung
Bioepis and Biogen Announce FDA Filing Acceptance of SB11, A Proposed Biosimilar Referencing Lucentis^{® (Ranibizumab)}

Samsung Bioepis Co., Ltd. and Biogen Inc. announced that the FDA has accepted for review the Biologics License Application for SB11, a proposed biosimilar referencing Lucentis^®. Ranibizumab is an anti-VEGF therapy for retinal vascular disorders, which are a leading cause of blindness in the United States.
[Samsung Bioepis Co., Ltd.]

Press Release

Idorsia
Announces Positive Results of the Two Japanese Registration Studies with Clazosentan

Idorsia Ltd announced positive top-line results of the Japanese registration program investigating clazosentan in adult Japanese patients post-aneurysmal subarachnoid hemorrhage (aSAH). The program consisted of two double-blind, randomized, placebo-controlled studies assessing the efficacy and safety of clazosentan in reducing vasospasm-related morbidity and all-cause mortality events in adult Japanese patients following aSAH.
[Idorsia Ltd]

Press Release

FEATURED EVENT

Macrophage
Expression and Prognostic Significance of the Long Pentraxin PTX3 in COVID-19

RIPK1
Expression Associates with Inflammation in Early Atherosclerosis in Humans and Can be Therapeutically Silenced to Reduce NF-κB Activation and Atherogenesis in Mice

Decreased
Blood Vessel Density and Endothelial Cell Subset Dynamics during Aging of the Endocrine System

LncRNA
MYLK-AS1 Facilitates Tumor Progression and Angiogenesis by Targeting miR-424-5p/E2F7 Axis and Activating VEGFR-2 Signaling Pathway in Hepatocellular Carcinoma

Human
Adipose-Derived Stem Cells Enriched with VEGF-Modified mRNA Promote Angiogenesis and Long-Term Graft Survival in a Fat Graft Transplantation Model

Coadministration
of Endothelial and Smooth Muscle Cells Derived from Human Induced Pluripotent Stem Cells as a Therapy for Critical Limb Ischemia

Blood-Derived
Extracellular Vesicles Isolated from Healthy Donors Exposed to Air Pollution Modulate In Vitro Endothelial Cells Behavior

In Vitro Modeling of Solid Tumor Interactions with Perfused Blood Vessels

Interleukin-8
Receptors CXCR1 and CXCR2 Are Not Expressed by Endothelial Colony-Forming Cells

Paracrine
Effect of Human Adipose-Derived Stem Cells on Lymphatic Endothelial Cells

Thrombocytopathy
and Endotheliopathy: Crucial Contributors to COVID-19 Thromboinflammation

Samsung
Bioepis and Biogen Announce FDA Filing Acceptance of SB11, A Proposed Biosimilar Referencing Lucentis^{® (Ranibizumab)}

Idorsia
Announces Positive Results of the Two Japanese Registration Studies with Clazosentan

The DNA Damage Response, Immunity and Aging

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PhD Candidate Position – Kidney Disease

Postdoctoral Studies – Cardiometabolic Research and NAFLD

Research Professional – Life Sciences

Research Scientist – Atherosclerosis and Cardiovascular Diseases

Studentships – Placental and Endothelial Cells in Pregnancy

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