Endothelial Cell News Volume 5.42 | Nov 30 2020

May 12, 2022

ENDOCN 5.42 | Nov 30 2020

Endothelial Cell News by STEMCELL Technologies

Vol. 5.42 – 30 November, 2020

TOP STORY

Targeting
PAK4 to Reprogram the Vascular Microenvironment and Improve CAR-T Immunotherapy for Glioblastoma

PAK4 knockout induced adhesion protein re-expression in endothelial cells, reduced vascular abnormalities, improved T cell infiltration and inhibits glioblastoma growth in mice.
[Nature Cancer]

Abstract

Virtual Conference Exhibition: Pluripotent Stem Cells

PUBLICATIONSRanked by the impact factor of the journal

Commensal-Driven Immune Zonation of the Liver Promotes Host Defence

Investigators used quantitative multiplex imaging, genetic perturbations, transcriptomics, infection-based assays and mathematical modeling to reassess the relationship between the localization of immune cells in the liver and host protection.
[Nature]

Abstract

A
Comprehensive Library of Human Transcription Factors for Cell Fate Engineering

Scientists demonstrated orthogonal programming by including oligodendrocyte-inducible human pluripotent stem cells (hPSCs) with unmodified hPSCs to generate cerebral organoids, which expedited in situ myelination.
[Nature Biotechnology]

Abstract

Olfactory
Transmucosal SARS-CoV-2 Invasion as a Port of Central Nervous System Entry in Individuals with COVID-19

SARS-CoV-2 could enter the nervous system by crossing the neural–mucosal interface in olfactory mucosa, exploiting the close vicinity of olfactory mucosal, endothelial and nervous tissue, including delicate olfactory and sensory nerve endings.
[Nature Neuroscience]

Full Article

A
High-Content Screen Identifies Drugs That Restrict Tumor Cell Extravasation across the Endothelial Barrier

Researchers performed a high-content screen to identify drugs that block tumor cell extravasation by testing 3520 compounds on a transendothelial invasion co-culture assay. Hits were further characterized and validated using a series of in vitro assays, a zebrafish model enabling 3D visualization of tumor cell extravasation, and mouse models of lung metastasis.
[Cancer Research]

Abstract

Endothelial
Specific YY1 Deletion Restricts Tumor Angiogenesis and Tumor Growthinnate and Innate-Like Immune Cells

VEGF-induced endothelial cell (EC) migration was diminished in Yin Yang 1 (YY1)-depleted HUVECs. A rescue experiment revealed that YY1-regulated BMP6 expression in ECs was involved in EC migration.
[Scientific Reports]

Full Article

Role
of Fibrocytes and Endothelial Progenitor Cells among Low-Differentiated CD34⁺ Cells in the Progression of Lung Sarcoidosis

Scientists characterized the CD34⁺ cell population in peripheral blood in patients with sarcoidosis (SA) with reference to the control group. In patients with SA, fibrocytes and endothelial cells were analyzed and their relationship to the fibrosis process based on assessment of diffusing capacity for carbon monoxide.
[BMC Pulmonary Medicine]

Full Article

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REVIEWS

Fibrosis: From Mechanisms to Medicines

The authors discuss the transformative experimental strategies that are being leveraged to dissect the key cellular and molecular mechanisms that regulate fibrosis, and the translational approaches that are enabling the emergence of precision medicine-based therapies for patients with fibrosis.
[Nature]

Abstract

INDUSTRY AND POLICY NEWS

7^th L’Oréal-UNESCO for Women in Science Middle East Regional Young Talents Program Recognizes Six Exceptional Female Scientists from the GCC

The L’Oréal-UNESCO For Women in Science Middle East Regional Young Talents Program, in partnership with Khalifa University of Science and Technology, awarded six winners in the Post-doctorate Researchers and PhD Students categories where Dr. Lama AlAbdi, Dr. Isra Marei, and Dr. Maryam Tariq Khaleel Alhashmi each received EUR20,000 in the Post-doctorate Researchers category.
[L’Oréal-UNESCO (Business Today)]

Press Release

FEATURED EVENT

Targeting
PAK4 to Reprogram the Vascular Microenvironment and Improve CAR-T Immunotherapy for Glioblastoma

Commensal-Driven Immune Zonation of the Liver Promotes Host Defence

A
Comprehensive Library of Human Transcription Factors for Cell Fate Engineering

Olfactory
Transmucosal SARS-CoV-2 Invasion as a Port of Central Nervous System Entry in Individuals with COVID-19

A
High-Content Screen Identifies Drugs That Restrict Tumor Cell Extravasation across the Endothelial Barrier

Endothelial
Specific YY1 Deletion Restricts Tumor Angiogenesis and Tumor Growthinnate and Innate-Like Immune Cells

Role
of Fibrocytes and Endothelial Progenitor Cells among Low-Differentiated CD34⁺ Cells in the Progression of Lung Sarcoidosis

Fibrosis: From Mechanisms to Medicines

7^th L’Oréal-UNESCO for Women in Science Middle East Regional Young Talents Program Recognizes Six Exceptional Female Scientists from the GCC

ISSCR 2021 Annual Meeting

> See All Events

PhD Candidate Position – Kidney Disease

Research Scientist – Atherosclerosis and Cardiovascular Diseases

Postdoctoral Studies – Cardiometabolic Research and NAFLD

Research Professional – Life Sciences

Studentships – Placental and Endothelial Cells in Pregnancy

> See All Jobs