 | | Vol. 5.44 – 14 December, 2020 |
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| The authors combined inducible genetic mosaics and transcriptomics to modulate and define the function of signaling pathways in cell proliferation, arteriovenous differentiation and mobilization.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that integrated analysis and engineering of gene regulatory networks in PSC-derived multilineage human liver organoids directed maturation and vascular morphogenesis in vitro.
[Cell Systems] |
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| Concomitant single-cell ATAC sequencing exposes underlying dynamics of open chromatin landscapes and regenerative gene regulatory networks of diverse cardiac cell types and reveals extracellular mediators of cardiomyocyte proliferation, angiogenesis, and fibroblast activation.
[Cell Reports] |
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| Investigators characterized the responses of alveolar epithelium and its adjacent microvascular endothelium to viral infection under a co-culture system. SARS-CoV-2 infection caused massive virus replication and dramatic organelles remodeling in alveolar epithelial cells, alone.
[Cell Death & Disease] |
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| Researchers showed that senescence triggered by BTG3 depletion was accompanied by a secretome enriched with cytokines, growth factors, and matrix-remodeling enzymes, which could promote angiogenesis and cell scattering in vitro.
[Cell Death & Disease] |
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| In vitro studies displayed that inhibition of SNHG5 with shRNA resulted in suppression of survival, cell cycle progression, migration/invasion of acute myelogenous leukemia and capacity of adhesion and angiogenesis in human umbilical vein endothelial cells.
[Laboratory Investigation] |
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| The authors analyzed metabolites inside lymphatic endothelial cells (LECs) in co-culture with MCF-7, MDA-MB-231, and SK-BR-3 breast cancer cell lines using 1H nuclear magnetic resonance metabolomics, Seahorse, and the spatial distribution of metabolic co-enzymes using optical redox ratio imaging to describe breast cancer-LEC metabolic crosstalk.
[Scientific Reports] |
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| Researchers tested the ability of the stem cells derived from bone marrow, dental pulp and dental apical papilla to engineer pericyte-supported vascular capillaries when encapsulated along with human umbilical vein endothelial cells in gelatin methacrylate hydrogel.
[Scientific Reports] |
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| Fibronectin containing extra domain A (FN-EDA) was positively correlated with pathological angiogenesis in hepatic fibrosis, and a reduction in FN-EDA expression was associated with diminished intrahepatic angiogenesis and fibrosis.
[Cell Death Discovery] |
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| Dynamic interactions between specific organ endothelial cells and different cellular components are crucial for different organ morphogenesis and function. Conversely, organs provide cues shaping vascular network structure.
[Experimental Cell Research] |
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| Synedgen announced that the University of New South Wales in partnership with Synedgen has been awarded an A$600,633, three-year, research grant from the Australian Research Council to advance knowledge of the biochemical and biophysical structure of the endothelial glycocalyx.
[Synedgen] |
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| Aerpio Pharmaceuticals, Inc. announced that razuprotafib met the primary efficacy endpoint at Day 28 with the twice-daily dose group in Aerpio’s double-blind, placebo-controlled Phase II trial in patients with elevated intraocular pressure associated with open angle glaucoma or ocular hypertension.
[Aerpio Pharmaceuticals, Inc.] |
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| January 25 – 28, 2021
Virtual |
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| | University of Buffalo – Buffalo, New York, United States |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | Stanford University – Stanford, California, United States |
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| | Universität Leipzig – Leipzig, Germany |
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