Endothelial Cell News Volume 6.00 | Jan 4 2021

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    2021-04-01 | ENDOCN 6.00


    Endothelial Cell News by STEMCELL Technologies
    Vol. 6.00 – 4 January, 2021
    TOP STORY

    Cardiomyocytes Stimulate Angiogenesis after Ischemic Injury in a ZEB2-Dependent Manner

    Investigators showed that the transcription factor zinc finger E-box-binding homeobox 2 (ZEB2) was increased in stressed cardiomyocytes and induces a cardioprotective cross-talk between cardiomyocytes and endothelial cells to enhance angiogenesis after ischemia.
    [Nature Communications]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Cancer-Secreted Exosomal miR-1468-5p Promotes Tumor Immune Escape via the Immunosuppressive Reprogramming of Lymphatic Vessels

    Scientists report a mechanistic model via which cervical cancer-secreted, exosome-encapsulated miR-1468-5p promoted lymphatic PD-L1 upregulation and lymphangiogenesis to impair T cell immunity.
    [Molecular Therapy]

    AbstractGraphical Abstract

    Cardiac Telocytes Inhibit Cardiac Microvascular Endothelial Cell Apoptosis through Exosomal miRNA-21-5p-Targeted cdip1 Silencing to Improve Angiogenesis following Myocardial Infarction

    Investigators showed that cardiac telocytes (CTs) inhibited cardiac microvascular endothelial cell apoptosis through exosomal miRNA-21-5p-targeted cell death inducing p53 target 1 silencing to improve angiogenesis in myocardial infarction.
    [Theranostics]

    Full Article

    The Effect of Proprotein Convertase Subtilisin Kexin Type 9 Inhibitors on Circulating Endothelial Progenitor Cells in Patients with Cardiovascular Disease

    Scientists explored the effect of proprotein convertase subtilisin kexin type 9 inhibitors on circulating endothelial progenitor cells hypothesizing a possible pleiotropic effect.
    [Cardiovascular Drugs and Therapy]

    Abstract

    Identification of a Human Whole Blood-Based Endothelial Cell Impedance Assay for Assessing Clinical TRPV4 Target Engagement Ex Vivo

    The ability of GSK2798745 to block TRPV4 agonist GSK1016790-induced impendence reduction in human umbilical vein endothelial cells in the presence of human whole blood was assessed.
    [Journal of Pharmacology and Experimental Therapeutics]

    Abstract

    miR-217 Promotes Endothelial Cell Senescence through the SIRT1/p53 Signaling Pathway

    Human umbilical vein endothelial cells (HUVECs) were used to replicate the aging model, and the population doubling levels during cell passage were counted. Senescence-associated β-galactosidase staining, real-time quantitative PCR, MTT assay, Transwell, and tube formation were used to detect the effects of miR-217 on young and senescent HUVECs.
    [Journal of Molecular Histology]

    Abstract

    Dasatinib Induces Endothelial-to-Mesenchymal Transition in Human Vascular-Endothelial Cells: Counteracted by Cotreatment with Bosutinib

    The authors investigated the effects of tyrosine kinase inhibitors (TKIs) on the development of endothelial-to-mesenchymal transition in human vascular-endothelial cells (VECs). Exposure of VECs to dasatinib, but not to other TKIs, produced a significant increase in the formation of spindle-shaped cells.
    [International Journal of Hematology]

    Abstract

    Vascular Tumor Recapitulated in Endothelial Cells from hiPSCs Engineered to Express the SERPINE1-FOSB Translocation

    Investigators engineered the pseudomyogenic hemangioendothelioma chromosomal translocation into human induced pluripotent stem cells using CRISPR/Cas9 and differentiate these into endothelial cells.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Derive and expand human endothelial cells with EC-Cultâ„¢-XF Culture Kit.
    REVIEWS

    The Role of Connexin Proteins and Their Channels in Radiation-Induced Atherosclerosis

    Scientists review the possible roles of intercellular connexin driven signaling and communication in radiation-induced atherosclerosis.
    [Cellular and Molecular Life Sciences]

    Abstract

    INDUSTRY AND POLICY NEWS

    Innovent Announces the NMPA Granted New Indication Approval for BYVASDA® (Bevacizumab Biosimilar) for the Treatment of Adult Recurrent Glioblastoma

    Innovent Biologics, Inc. announced that BYVASDA®, a recombinant humanized anti-VEGF monoclonal antibody drug independently developed by Innovent, has been officially approved by the National Medical Products Administration of China for the treatment of adult recurrent glioblastoma, which is the third approved indication of BYVASDA® in China.
    [Innovent Biologics, Inc.]

    Press Release

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    JOB OPPORTUNITIES

    PhD Studentships – Endo-Lysosomal Processes in Cardio-Metabolic Diseases

    University Medical Center Groningen – Groningen, Netherlands

    Postdoctoral Fellow / Assistant Staff Scientist – Endothelial Metabolism

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    Postdoctoral Research – Innate Immunity & Endothelial Permeability

    University of Illinois at Chicago – Chicago, Illinois, United States

    Postdoctoral Associate – Vascular Mechanobiology

    University of Buffalo – Buffalo, New York, United States

    Research Professional – Life Sciences

    Stanford University – Stanford, California, United States

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