| Vol. 6.00 – 4 January, 2021 |
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| Investigators showed that the transcription factor zinc finger E-box-binding homeobox 2 (ZEB2) was increased in stressed cardiomyocytes and induces a cardioprotective cross-talk between cardiomyocytes and endothelial cells to enhance angiogenesis after ischemia. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists report a mechanistic model via which cervical cancer-secreted, exosome-encapsulated miR-1468-5p promoted lymphatic PD-L1 upregulation and lymphangiogenesis to impair T cell immunity. [Molecular Therapy] |
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| Investigators showed that cardiac telocytes (CTs) inhibited cardiac microvascular endothelial cell apoptosis through exosomal miRNA-21-5p-targeted cell death inducing p53 target 1 silencing to improve angiogenesis in myocardial infarction. [Theranostics] |
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| Scientists explored the effect of proprotein convertase subtilisin kexin type 9 inhibitors on circulating endothelial progenitor cells hypothesizing a possible pleiotropic effect. [Cardiovascular Drugs and Therapy] |
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| The ability of GSK2798745 to block TRPV4 agonist GSK1016790-induced impendence reduction in human umbilical vein endothelial cells in the presence of human whole blood was assessed. [Journal of Pharmacology and Experimental Therapeutics] |
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| Human umbilical vein endothelial cells (HUVECs) were used to replicate the aging model, and the population doubling levels during cell passage were counted. Senescence-associated β-galactosidase staining, real-time quantitative PCR, MTT assay, Transwell, and tube formation were used to detect the effects of miR-217 on young and senescent HUVECs. [Journal of Molecular Histology] |
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| The authors investigated the effects of tyrosine kinase inhibitors (TKIs) on the development of endothelial-to-mesenchymal transition in human vascular-endothelial cells (VECs). Exposure of VECs to dasatinib, but not to other TKIs, produced a significant increase in the formation of spindle-shaped cells. [International Journal of Hematology] |
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| Investigators engineered the pseudomyogenic hemangioendothelioma chromosomal translocation into human induced pluripotent stem cells using CRISPR/Cas9 and differentiate these into endothelial cells. [Cell Reports Medicine] |
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| Scientists review the possible roles of intercellular connexin driven signaling and communication in radiation-induced atherosclerosis. [Cellular and Molecular Life Sciences] |
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| Innovent Biologics, Inc. announced that BYVASDA®, a recombinant humanized anti-VEGF monoclonal antibody drug independently developed by Innovent, has been officially approved by the National Medical Products Administration of China for the treatment of adult recurrent glioblastoma, which is the third approved indication of BYVASDA® in China. [Innovent Biologics, Inc.] |
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| February 3 – 23, 2021 Virtual |
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| University Medical Center Groningen – Groningen, Netherlands |
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| Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| University of Illinois at Chicago – Chicago, Illinois, United States |
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| University of Buffalo – Buffalo, New York, United States |
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| Stanford University – Stanford, California, United States |
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