| Vol. 6.01 – 11 January, 2021 |
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| Investigators demonstrated using an embryonic stem cell model that transient expression of the T-box transcription factor Eomesodermin governed hemogenic competency of extra-embryonic mesoderm. [Nature Cell Biology] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Atherosclerosis was studied in the ascending aortic arch and compared to mice without bone marrow transplantation (BMT). In BMT mice, neutral lipid and myeloid cell topography were lower in lesions after feeding a cholesterol-rich diet for three, six and 12 weeks. [Circulation Research] |
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| Scientists showed that the transcription factor zinc finger E-box-binding homeobox 2 (ZEB2) was increased in stressed cardiomyocytes and induces a cardioprotective cross-talk between cardiomyocytes and endothelial cells to enhance angiogenesis after ischemia. [Nature Communications] |
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| A novel modular microfluidic system with a vertical two-layered configuration was developed to generate large-scale perfused microvascular networks in vitro. [Microsystems & Nanoengineering] |
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| Researchers characterized the expression of IL-36 members in human primary trophoblast cells and trophoblastic cell lines and upon treatment with bacterial and viral components. [International Journal of Molecular Sciences] |
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| Scientists conducted a crossing study evaluating microvascular density, endothelial area, and Ki-67 proliferative index was reported for a series of formalin-fixed and paraffin-embedded tissue samples from 99 cat patients, affected by cat post-injection fibrosarcoma, by using a till ×400 magnification light microscopy. [Cells] |
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| The authors established a novel zebrafish transgenic line expressing eGFP under the control of part of the zebrafish Basic Leucine Zipper ATF‐Like Transcription Factor 3 (batf3) promoter. Spatiotemporal examination of Tg(batf3MIN:eGFP) transgenic fish revealed a typical lymphatic expression pattern, which does not perfectly recapitulate the expression pattern of existing lymphatic endothelial cell transgenic lines. [Developmental Dynamics] |
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| Investigators describe that the stemness and differentiation potential of cancer stem cells were enhanced under hypoxic microenvironments, through hypoxia-induced epithelial-endothelial transition and extracellular matrix remodeling to form the specific mechanism of vasculogenic mimicry. [Molecular Cancer] |
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| Adverum Biotechnologies, Inc. announced the completion of patient enrollment in the INFINITY Phase II trial to evaluate a single intravitreal injection of ADVM-022, for the treatment of diabetic macular edema. [Adverum Biotechnologies, Inc.] |
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| February 3 – 23, 2021 Virtual |
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| Fondazione Human Technopole – Milan, Italy |
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| University Medical Center Groningen – Groningen, Netherlands |
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| Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| University of Illinois at Chicago – Chicago, Illinois, United States |
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| University of Buffalo – Buffalo, New York, United States |
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