Endothelial Cell News Volume 6.02 | Jan 18 2020

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    2020-01-19 | ENDOCN 6.02


    Endothelial Cell News by STEMCELL Technologies
    Vol. 6.02 – 18 January, 2021
    TOP STORY

    Carbon
    Nano-Onion-Mediated Dual Targeting of P-Selectin and P-Glycoprotein to Overcome Cancer Drug Resistance

    Investigators report a fucoidan-decorated silica-carbon nano-onion hybrid nanoparticle that targeted tumor vasculature to specifically release P-glycoprotein inhibitor and anticancer drug into tumor cells.
    [Nature Communications]

    Full Article

    Derive and expand human endothelial cells with EC-Cultâ„¢-XF Culture Kit.
    PUBLICATIONSRanked by the impact factor of the journal

    An Immunohistochemical Study of Lymphatic Elements in the Human Brain

    Lymphatic marker-positive cells were present in the perivascular space, the walls of small and large arteries and veins, the media of large vessels along smooth muscle cell membranes, and the vascular adventitia.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Methotrexate Attenuates Vascular Inflammation through an Adenosine-MicroRNA Dependent Pathway

    The authors identify that the drug methotrexate and its downstream metabolite adenosine exert anti-inflammatory effects in the vascular endothelium by targeting and activating MiR-181b expression.
    [eLife]

    Abstract

    MALAT1
    Sponges miR-26a and miR-26b to Regulate Endothelial Cell Angiogenesis via PFKFB3-Driven Glycolysis in Early-Onset Preeclampsia

    In vitro assays revealed that 6-phosphofructo-2-kinase (PFKFB3) regulated the proliferation, migration and tube formation of endothelial cells by modulating glycolysis.
    [Molecular Therapy-Nucleic Acids]

    AbstractFull Article
    Graphical Abstract

    PU.1
    Drives Specification of Pluripotent Stem Cell-Derived Endothelial Cells to LSEC-Like Cells

    Researchers present a computational workflow that could identify transcription factors that are crucial for modulating pathways involved in cell lineage specification.
    [Cell Death & Disease]

    Full Article

    Treatment
    with Atorvastatin during Vascular Remodeling Promotes Pericyte-Mediated Blood-Brain Barrier Maturation Following Ischemic Stroke

    Scientists examined the hypothesis that, during vascular remodeling after stroke, treatment with atorvastatin could facilitate blood-brain barrier maturation in remodeling vasculature in ischemic brain.
    [Translational Stroke Research]

    Abstract

    HIF-1α
    Promotes Cellular Growth in Lymphatic Endothelial Cells Exposed to Chronically Elevated Pulmonary Lymph Flow

    The authors investigated molecular mechanisms that altered the growth and metabolism of isolated lymphatic endothelial cells exposed to prolonged pathologically elevated lymph flow in vivo within the anatomic and physiologic context of a large animal model of congenital heart disease with increased pulmonary blood flow using in vitro approaches.
    [Scientific Reports]

    Full Article

    Fenofibrate
    Attenuates Doxorubicin-Induced Cardiac Dysfunction in Mice via Activating the eNOS/EPC Pathway

    Investigators tested whether fenofibrate, with its anti-inflammatory and vasoprotective effects, could improve myocardial function by activating endothelial progenitor cells through the eNOS pathway in a doxorubicin-induced cardiomyopathy mouse model.
    [Scientific Reports]

    Full Article

    Conditioned
    Media from Endothelial Progenitor Cells Cultured in Simulated Microgravity Promote Angiogenesis and Bone Fracture Healing

    Human peripheral blood-derived endothelial progenitor cells were cultured under microgravity (MG) or normal gravity (NG) followed by analysis for angiogenic gene expression. Furthermore, the serum-free cultured medium under MG or NG were collected, and their pro-angiogenic properties were examined in HUVECs.
    [Current Stem Cell Research & Therapy]

    Full ArticleGraphical Abstract

    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    REVIEWS

    The Evolving Cardiac Lymphatic Vasculature In Development, Repair And Regeneration

    The authors discuss the cardiac lymphatic vasculature with a focus on developments over the past five years arising from the study of mammalian and zebrafish model organisms.
    [Nature Reviews Cardiology]

    Full Article

    Harnessing Mechanobiology for Tissue Engineering

    Scientists review and propose the development of different approaches, from providing appropriate extracellular mechanical cues to interfering with cellular mechanosensing machinery, to aid in controlling cell and tissue structure and function.
    [Developmental Cell]

    Full Article
    INDUSTRY AND POLICY NEWS

    International Trial to Compare Bioadaptor, a Novel Coronary Artery Implant Designed to Adapt to Vessel Physiology, with Traditional Drug Eluting Stents

    Elixir Medical announced that the first patient has been treated in the BIOADAPTOR randomized controlled trial of the DynamXâ„¢ Coronary Bioadaptor System, the first drug-eluting coronary artery implant that adapts to vessel physiology.
    [Elixir Medical]

    Press Release

    FEATURED EVENT

    The 3rd
    UK Cellular Microbiology Network

    March 1 – 2, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Experimental Genetics Researcher – IBS, and the Immune/Microbiome/Endothelial Axis

    University of California San Francisco – San Francisco, California, United States

    Senior
    Manager – FACS-Based Characterization

    Fondazione Human Technopole – Milan, Italy

    PhD Studentships – Endo-Lysosomal Processes in Cardio-Metabolic Diseases

    University Medical Center Groningen – Groningen, Netherlands

    Postdoctoral Fellow/Assistant Staff Scientist – Endothelial Metabolism

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    Postdoctoral Associate – Vascular Mechanobiology

    University of Buffalo – Buffalo, New York, United States

    > See All Jobs

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