| Vol. 6.02 – 18 January, 2021 |
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| Investigators report a fucoidan-decorated silica-carbon nano-onion hybrid nanoparticle that targeted tumor vasculature to specifically release P-glycoprotein inhibitor and anticancer drug into tumor cells. [Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Lymphatic marker-positive cells were present in the perivascular space, the walls of small and large arteries and veins, the media of large vessels along smooth muscle cell membranes, and the vascular adventitia. [Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors identify that the drug methotrexate and its downstream metabolite adenosine exert anti-inflammatory effects in the vascular endothelium by targeting and activating MiR-181b expression. [eLife] |
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| In vitro assays revealed that 6-phosphofructo-2-kinase (PFKFB3) regulated the proliferation, migration and tube formation of endothelial cells by modulating glycolysis. [Molecular Therapy-Nucleic Acids] |
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| Researchers present a computational workflow that could identify transcription factors that are crucial for modulating pathways involved in cell lineage specification. [Cell Death & Disease] |
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| Scientists examined the hypothesis that, during vascular remodeling after stroke, treatment with atorvastatin could facilitate blood-brain barrier maturation in remodeling vasculature in ischemic brain. [Translational Stroke Research] |
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| The authors investigated molecular mechanisms that altered the growth and metabolism of isolated lymphatic endothelial cells exposed to prolonged pathologically elevated lymph flow in vivo within the anatomic and physiologic context of a large animal model of congenital heart disease with increased pulmonary blood flow using in vitro approaches. [Scientific Reports] |
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| Investigators tested whether fenofibrate, with its anti-inflammatory and vasoprotective effects, could improve myocardial function by activating endothelial progenitor cells through the eNOS pathway in a doxorubicin-induced cardiomyopathy mouse model. [Scientific Reports] |
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| Human peripheral blood-derived endothelial progenitor cells were cultured under microgravity (MG) or normal gravity (NG) followed by analysis for angiogenic gene expression. Furthermore, the serum-free cultured medium under MG or NG were collected, and their pro-angiogenic properties were examined in HUVECs. [Current Stem Cell Research & Therapy] |
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| The authors discuss the cardiac lymphatic vasculature with a focus on developments over the past five years arising from the study of mammalian and zebrafish model organisms. [Nature Reviews Cardiology] |
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| Scientists review and propose the development of different approaches, from providing appropriate extracellular mechanical cues to interfering with cellular mechanosensing machinery, to aid in controlling cell and tissue structure and function. [Developmental Cell] |
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| Elixir Medical announced that the first patient has been treated in the BIOADAPTOR randomized controlled trial of the DynamXâ„¢ Coronary Bioadaptor System, the first drug-eluting coronary artery implant that adapts to vessel physiology. [Elixir Medical] |
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| University of California San Francisco – San Francisco, California, United States |
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| Fondazione Human Technopole – Milan, Italy |
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| University Medical Center Groningen – Groningen, Netherlands |
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| Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| University of Buffalo – Buffalo, New York, United States |
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