 | | Vol. 6.05 – 8 February, 2021 |
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| Researchers identified rare LNGFR+ cells in human fetal and regenerative bone marrow that co-expressed endothelial and stromal markers. This endothelial subpopulation displayed transcriptional reprogramming consistent with endothelial-to-mesenchymal transition and could generate multipotent stromal cells that reconstituted the bone marrow niche upon transplantation.
[Cell Stem Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Data from liquid chromatography-mass spectrometry and microscale thermophoresis informed the development of a novel antibody to inhibit platelet-endothelial adhesion, which was tested in cells from chronic thromboembolic pulmonary hypertension patients and three animal models in vivo.
[American Journal of Respiratory and Critical Care Medicine] |
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| Scientists demonstrated that induced brain microvascular endothelial cells lacked functional attributes of endothelial cells since they were deficient in vascular lineage genes while expressing clusters of genes related to the neuroectodermal epithelial lineage.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| ERO1 alpha deficiency reduced tumor cell migration and lung metastases by impinging on tumor angiogenesis, negatively regulating the upstream ATF4/CHOP branch of the Unfolded Protein Response and selectively impeding oxidative folding of angiogenic factors, among which VEGF-A.
[Oncogene] |
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| Endothelial‐specific EVL deletion compromised the radial sprouting of the vascular plexus and reduced the endothelial tip cell density and filopodia formation.
[EMBO Reports] |
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| Investigators found that small nucleolar RNA host gene 16 (SNHG16) expression was significantly up-regulated in human retinal microvascular endothelial cells (hRMECs) treated with high glucose. Functionally, SNHG16 could facilitate hRMEC proliferation, migration and angiogenesis.
[Molecular Therapy-Nucleic Acids] |
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| Scientists provide the first proof of concept in silico/in vivo study demonstrating that filopodia played an unexpected role in speeding up collective endothelial decisions during the time-constrained process of ‘tip cell’ selection during blood vessel formation.
[Philosophical Transactions of the Royal Society B-Biological Sciences] |
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| The authors investigated the potential of extracellular vesicles derived from HUVECs to transfer miR-203 to affect the progression of non-small cell lung cancer.
[Cancer Gene Therapy] |
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| To detect and visualize endoglin mRNA in oxygen-induced retinopathy mice, researchers designed and synthesized a novel imaging probe composed of short-hairpin anti-sense endoglin RNA coupled to a fluorophore and black hole quencher.
[Scientific Reports] |
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| In Sprague–Dawley rats, hindlimb ischemia was generated by femoral artery removal, then seven days after ischemic induction 1×105 SB623 cells or PBS was injected into the ischemic adductor muscle.
[Scientific Reports] |
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| Using a nonobese T2DN diabetes mellitus (DM) rat, the authors isolated parenchymal arterioles, cultured cerebral microvascular pericytes, and examined whether cerebrovascular pericyte in DM was damaged and whether pericyte dysfunction may play a role in the regulation of cerebral hemodynamics and blood-brain barrier integrity.
[American Journal of Physiology-Heart and Circulatory Physiology] |
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| Scientists summarize recent in vitro and in vivo findings on the importance of endothelial cell receptors and uptake pathways in regulating fatty acids and cholesterol uptake in normal physiology and cardiovascular disease.
[Circulation Research] |
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| The authors overview the upstream signals from the tumor microenvironment that control endothelial YAP/TAZ activation and explore the role of their downstream targets in driving tumor angiogenesis.
[Frontiers in Oncology] |
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| Connectyx Technologies Holdings Group, Inc. announced it has entered into an Exclusive Patent License Agreement to practice inventions contained within the patent applications listed below with the National Eye Institute, of the National Institutes of Health, including the repurposed use of Metformin to treat Retinal Degeneration.
[Connectyx Technologies Holdings Group, Inc.] |
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| April 27 – 30, 2021
Virtual |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | F. Hoffmann-La Roche AG – Basel, Switzerland |
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| | University of Birmingham – Birmingham, England, United Kingdom |
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| | University of California San Francisco – San Francisco, California, United States |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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Pancreatic Cell News
Prostate Cell News
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