 | | Vol. 6.07 – 1 March, 2021 |
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| Scientists developed a microRNA-21-5p delivery system using functionalized mesoporous silica nanoparticles with additional intrinsic therapeutic effects.
[Science Advances] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Multiphoton ablation combined with guided endothelial cell growth from pre‐formed microvessels was used to successfully create perfusable and cellularized organ‐specific microvascular structures at anatomic scale within collagen hydrogels.
[Advanced Healthcare Materials] |
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| HUVECs were transfected with miR-181a inhibitor/mimic or siRNA-MLL3, or treated with exosomes from hypoxic papillary thyroid cancer cells. Hypoxic exosomal miR-181a delivery promoted proliferation and capillary-like network formation in HUVECs.
[Molecular Therapy-Nucleic Acids] |
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| Researchers present a vascularized micro-tumor that is a novel three-dimensional model system that recapitulated the complex human tumor microenvironment, including perfused vasculature, within a transparent microfluidic device, allowing real-time study of drug responses and tumor-stromal interactions.
[Lab On A Chip] |
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| Scientists assembled five groups of chosen endothelial progenitor cells (EPCs)-related genes/factors using PubMed literature and Gene Ontology databases. This shortened database of EPC factors was fed into publically published transcriptome matrix to compare their expression between endothelial colony-forming cells, HUVECs, and two adult endothelial cell types from the skin and adipose tissue.
[Stem Cell Research & Therapy] |
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| The upregulation of cyclic AMP responsive element-binding protein 3-like 4 (CREB3L4) in gastic cancer cells increased cell viability, promoted cell proliferation, reduced apoptosis, enhanced cell migration and invasion, and induced the formation of tubule-like endothelial structures, whereas CREB3L4 knockdown impeded tumor cell growth, attenuated cell motility, and prevented human umbilical vein endothelial cells from forming tubule-like structures.
[Cancer Gene Therapy] |
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| Exosomes were isolated from MSCs using ultracentrifugation, and further characterized by the nanoparticle tracking analyzer and flow cytometry. RNA sequencing, Western Blot, in vitro cell proliferation, in vivo pro-angiogenesis, as well as ischemic repairment of diabetic foot through rat model were performed to evaluate exosome physiological functions.
[Stem Cell Research] |
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| The in vivo results showed that FGF21 efficiently improved blood perfusion and ischaemic angiogenesis in both type 1 and type 2 diabetic mice, and these effects were accompanied by enhanced endothelial progenitor cells mobilization and infiltration into ischemic muscle tissues and increases in plasma stromal cell–derived factor‐1 concentration.
[Journal of Cellular and Molecular Medicine] |
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| Using an in vitro model of the human microvasculature, researchers assessed the importance of the tumor and vascular glycocalyces during tumor cell extravasation.
[Communications Biology] |
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| Production of human jawbone models was realized via projection-based stereolithography. Constructs were bioprinted containing primary jawbone-derived osteoblasts and vasculature-like channel structures optionally harboring primary endothelial cells.
[Scientific Reports] |
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| The authors determined that Tspan18, a member of the Tetraspanin family, was expressed in developing vessels but not in mature vasculature in zebrafish and mouse wound healing. Reduction at Tspan18 level resulted in aberrant vascular patterning, impaired vessel stability and defective arterial–venous specification.
[Biology Open] |
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| Investigators review recent developments and challenges related to selected blood-brain barrier-crossing strategies- with a focus on non-invasive approaches such as receptor-mediated transcytosis and the use of neurotropic viruses, nanoparticles and exosomes- and analyze their potential in the treatment of central nervous system disorders.
[Nature Reviews Drug Discovery] |
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| Scientists discuss recent insights into new players whose identification has contributed to deciphering the lymphatic regulatory code.
[Developmental Cell] |
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| The authors explain some of the reasons that implicate hypertension as a major risk factor for stroke among the Japanese population.
[Environmental Health and Preventive Medicine] |
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| Glaukos Corporation announced that US Phase III pivotal trial results for its next-generation corneal cross-linking iLink™ therapy for the treatment of keratoconus, known as Epi-on, met the study’s primary efficacy endpoint, demonstrating a statistically significant improvement in maximum corneal curvature at six months from baseline between the treated and placebo-controlled arms.
[Glaukos Corporation] |
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| Morphic Therapeutic announced positive interim results from its Phase I clinical trial of MORF-057, an oral small molecule inhibitor of the α4β7 integrin in development for the treatment of inflammatory bowel disease.
[ Morphic Therapeutic ] |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | CyberCoders – San Diego, California, United States |
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| | Imperial College London – London, England, United States |
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| | University of California, San Diego – La Jolla, California, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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