 | | Vol. 6.10 – 29 March, 2021 |
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| Scientists identified the kinase Arg/Abl2 as a mediator of endothelial barrier disruption, but the role of Arg in endothelial monolayer regulation and its relevance in vivo remained poorly understood.
[Angiogenesis] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators demonstrated the capability of artificial-intelligence velocimetry by quantifying hemodynamics in microchannels designed to mimic saccular-shaped microaneurysms, which signified common manifestations of diabetic retinopathy, a leading cause of vision loss from blood-vessel damage in the retina in diabetic patients.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors found elevated levels of circulating endothelial cells, a biomarker of vascular injury, in COVID-19 convalescents compared to healthy controls.
[eLife] |
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| Researchers hypothesized that cAMP response element-binding protein (CREB) associated with KMT5A to modulate PTP1B expression, thus contributing to high glucose-mediated glomerular endothelial inflammation.
[Cell Death & Disease] |
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| Reduction of protein/creatinin was observed in p53sh‐endothelial progenitor cell (EPC)‐transplanted mice more than null‐EPC or null‐mouse mesenchymal stromal cell transplanted mice.
[Journal of the American Heart Association] |
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| Scientists showed that Jak3 was expressed in endothelial cells across hematopoietic and non-hematopoietic organs, with heightened expression in the bone marrow.
[Communications Biology] |
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| It was initially confirmed that escin, at concentrations >10 µM, significantly inhibited the proliferation of several pancreatic cancer cell lines.
[Oncology Reports] |
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| Researchers isolated human dermal microvascular endothelial cells (HDMECs) from the skin of ten patients with psoriasis and ten healthy subjects and compared angiogenesis, proliferation, migration and cell metabolism between psoriatic HDMECs and normal HDMECs.
[Experimental Dermatology] |
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| ox-LDL inhibited circRSF1 and histone deacetylase 1 (HDAC1) expression while upregulated miR-135b-5p expression in HUVECs.
[Biological Research] |
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| After an overview of the morphology and structure of pericytes, scientists describe their interactions with both the basement membrane and endothelial cells.
[Journal of Cell Science] |
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| Investigators discussed the wound-healing process, present methods used for stem cells administration, methods of enhancing stem cells potency and human studies.
[Experimental Dermatology] |
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| Hutchison China MediTech Limited has initiated a Phase Ib/II study of surufatinib in combination with BeiGene’s tislelizumab in patients with advanced solid tumors in the US and Europe.
[Hutchison China MediTech Limited] |
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September 5 – 8, 2021
Exeter, England, United Kingdom |
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| | Mount Sinai – New York, New York, United States |
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| | Seattle Children’s Hospital – Seattle, Washington, United States |
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| | University of Hong Kong – Hong Kong, China |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | CyberCoders – San Diego, California, United States |
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