 | | Vol. 6.11 – 5 April, 2021 |
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| Researchers showed that the metabolite S-2-hydroxyglutarate played a crucial role in the regulation of endothelial quiescence
[Nature Cell Biology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that stents releasing exosomes derived from mesenchymal stem cells in the presence of reactive oxygen species enhance vascular healing in rats with renal ischemia-reperfusion injury, promoting endothelial cell tube formation and proliferation, and impairing the migration of smooth muscle cells.
[Nature Biomedical Engineering] |
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| Investigators describe a detailed alternative method to cultivate millimeter-scale functional vascularized tissues on a biofabricated platform that enabled facile incorporation of organoid technology.
[Nature Protocols] |
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| To enable cell-type-specific gene manipulation in vitro, scientists establish an organoid system via coculture of endothelial cells (ECs), fibroblasts, and mammary epithelial cells.
[Cell Reports] |
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| Researchers compared the expressive differences between tumor-derived endothelial cells (TECs) and normal endothelial cells and revealed higher expression of several metabolism-related genes in TECs.
[Molecular Therapy-Nucleic Acids] |
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| Scientists summarize the current knowledge on the role of the cell death signaling machinery with a focus on the apoptosis and necroptosis signaling pathways during blood vessel formation in development and pathology.
[Cellular and Molecular Life Sciences] |
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| HUVECs and human lung microvascular endothelial cells incubated with human sickle cell plasma had significant increases in pro-inflammatory IL-8, IL-6, and soluble VCAM-1 secretion compared to endothelial cells incubated with normal plasma.
[Frontiers in Immunology] |
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| Using synthetic hyaluronic acid hydrogels as a chemically and mechanically tunable system to preserve lymphatic endothelial cell phenotypes, scientists demonstrated that low matrix elasticity primed lymphatic cord‐like structure formation directed by a high concentration of vascular endothelial growth factor‐C.
[FASEB Journal] |
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| The authors delineated signaling pathways mediating endothelial-to-osteoblast transition using endothelial cell lines 2H11 and SVR.
[iScience] |
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| Researchers demonstrated that a reduced opticin levels in ROP vitreous are regulated by matrix metalloproteinases (MMPs) secreted by activated microglia.
[Scientific Reports] |
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| Investigators describe the pathways that cells follow to form the primary embryonic circulatory system in the mouse embryo.
[BMC Developmental Biology] |
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| The authors discussed the Ca2+ entry pathways at the plasma membrane, Ca2+ released signals from the intracellular stores, the functional and physiological relevance of Ca2+ signals, and their regulatory mechanisms.
[Comprehensive Physiology] |
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| Scientists highlight potential pro-angiogenic mechanisms of transplanted MSCs and the derived EVs after acute myocardial infarction and summarize the latest literature concerning the novel methods based on MSCs to maximize the angiogenesis capability.
[Stem Cells and Development] |
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| Outlook Therapeutics, Inc. announced positive topline results from its NORSE THREE open-label safety study evaluating ONS-5010 / LYTENAVA™ to treat retinal diseases.
[Outlook Therapeutics, Inc.] |
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| Exelixis, Inc. announced its partner Ipsen received approval from the European Commission for CABOMETYX® in combination with OPDIVO® as a first-line treatment for advanced renal cell carcinoma.
[Exelixis, Inc.] |
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| October 27 – 29, 2021
Tokyo, Japan |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Mount Sinai Health System – New York, New York, United States |
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| | Seattle Children’s Hospital – Seattle, Washington, United States |
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| | University of Hong Kong – Hong Kong, China |
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