Endothelial Cell News Volume 6.12 | Apr 12 2021

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    Justin.choi
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    2021-04-12 | ENDOCN 6.12


    Endothelial Cell News by STEMCELL Technologies
    Vol. 6.12 – 12 April, 2021
    TOP STORY

    Endothelial Struts Enable the Generation of Large Lumenized Blood Vessels De Novo

    Researchers describe a model for large vessel formation that does not require a cord-like structure or a hollowing step.
    [Nature Cell Biology]

    AbstractPress Release
    Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.
    PUBLICATIONSRanked by the impact factor of the journal

    Zebrafish scube1 and scube2 Cooperate in Promoting Vegfa Signaling during Embryonic Vascularization

    To further dissect the genetic interactions of these scube genes, transcription activator-like effector nuclease-mediated genome editing was used to generate knockout alleles of each scube gene.
    [Cardiovascular Research]

    AbstractGraphical
    Abstract

    CCL8 Mediates Crosstalk between Endothelial Colony Forming Cells and Triple-Negative Breast Cancer Cells through IL-8, Aggravating Invasion and Tumorigenicity

    Using an indirect co-culture system, scientists showed that co-culture increased the invasive and migratory phenotypes of both MDA-MB-231 triple-negative breast cancer cells and endothelial colony-forming cells.
    [Oncogene]

    Abstract

    Coordinated Interactions between Endothelial Cells and Macrophages in the Islet Microenvironment Promote β Cell Regeneration

    The authors showed that proliferative endothelial cells modulated macrophage (MΦ) infiltration and phenotype during β cell loss, and recruited MΦs were essential for β cell recovery.
    [npj Regenerative Medicine]

    Full Article

    Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Crest Cells for Corneal Endothelial Regeneration

    Transplantation of the human induced pluripotent stem cells-derived neural crest cells rapidly restored rabbit corneal thickness and clarity. However, the long-term recovery efficacy was impaired by the improper maturation, senescence, and endothelial-mesenchymal transition of the transplanted cells.
    [Stem Cell Research & Therapy]

    Full Article

    Endothelial SIRT3 Regulates Myofibroblast Metabolic Shifts in Diabetic Kidneys

    Researchers found that endothelial SIRT3 regulated metabolic reprogramming and fibrogenesis in the kidneys of diabetic mice.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Gene Expression Profiling of Brain Endothelial Cells after Experimental Subarachnoid Hemorrhage

    Investigators used gene expression profiling to identify 707 unique genes that were significantly differentially expressed in mouse brain endothelial cells after subarachnoid hemorrhage.
    [Scientific Reports]

    Full Article

    Propofol Inhibits Tumor Angiogenesis through Targeting VEGF/VEGFR and mTOR/eIF4E Signaling

    Scientists showed that propofol inhibited tubular structure formation of both lung cancer associated endothelial cells and colon cancer associated endothelial cells, particularly the early stages of angiogenesis.
    [Biochemical and Biophysical Research Communications]

    Abstract

    Defining the Lineage of Thermogenic Perivascular Adipose Tissue

    The cellular origins of perivascular adipose tissue are poorly understood. The authors determined the identity of perivascular adipocyte progenitors in mice and humans
    [Nature Metabolism]

    Abstract
    Derive and expand human endothelial cells with EC-Cultâ„¢-XF Culture Kit.
    REVIEWS

    Vascular Stress Signaling in Hypertension

    Investigators discuss common adaptive signaling mechanisms against these stresses including unfolded protein responses, antioxidant response element signaling, autophagy, mitophagy, and mitochondrial fission/fusion, signaling effector stimulator of interferon genes-mediated responses, and activation of pattern recognition receptors.
    [Circulation Research]

    Full Article

    Obesity, Adipose Tissue and Vascular Dysfunction

    The authors discuss the local and systemic roles of adipose tissue derived secreted factors and increased systemic inflammation during obesity and highlight their detrimental impact on cardiovascular health.
    [Circulation Research]

    Full Article

    Oxidative Stress and Endothelial Dysfunction in Sepsis and Acute Inflammation

    Scientists cover the current understanding of the role of oxidative stress (OS) in the endothelial adaptive or maladaptive multifaceted response to sepsis and to outline the therapeutic potential and issues of targeting OS and endothelial dysfunction during sepsis and septic shock.
    [Antioxidants & Redox Signaling]

    Full Article

    INDUSTRY AND POLICY NEWS

    NIH-Funded Consortium Focuses on Advancing Genome Editing Research

    The Somatic Cell Genome Editing Consortium, a massive research effort funded by the National Institutes of Health, aims to accelerate genome editing research and the development of new gene-editing related technologies and therapeutic approaches.
    [Baylor College of Medicine]

    Press Release
    FEATURED EVENT

    ISSCR: Stem Cells – From Basic Science to Clinical Translation

    October 27 – 29, 2021
    Tokyo, Japan

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Vascular Networks

    Boston Children’s Hospital – Boston, Massachusetts, United States

    Research Technician – Cardiovascular Biology

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    Postdoctoral Associate – Vascular Diseases of the Eye and Cancer

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Fellow – Smooth Muscle and Endothelial Cells

    Mount Sinai – New York, New York, United States

    Postdoctoral Fellow – Endothelial Dysfunction and Malaria

    Seattle Children’s Hospital – Seattle, Washington, United States

    > See All Jobs

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