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| Induced pluripotent stem cell-derived endothelial cells generated from six patients with pulmonary arterial hypertension were exposed to 4500 compounds and assayed for improved cell survival after serum withdrawal using a chemiluminescent caspase assay.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Skin wound analysis from Sox9 conditional knock-out mice demonstrated a significant reduction in pathological endothelial to mesenchymal transition (EndMT) resulting in reduced scar area. The converse was observed with Rbpj conditionally knocked-out from the murine vasculature or inhibition of Notch signaling in human endothelial colony forming cells, resulting in enhanced Sox9 and EndMT related gene
[Nature Communications] |
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| Researchers identified trafficking pathways that regulated collagen type IV (Col IV) deposition during angiogenic blood vessel development. They identified the GTPase Rab10 as a major regulator of Col IV vesicular trafficking during vascular development using both in vitro imaging and biochemistry as well as in vivo models.
[Angiogenesis] |
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| Scientists measured the susceptibility to infection, immune response, and expression of adhesion molecules, in human pulmonary microvascular endothelial cells exposed to conditioned medium from infected epithelial cells.
[Clinical Infectious Diseases] |
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| Investigators designed supramolecular nanofibers self-assembled by compound 1, which could strongly activate the hepatocyte growth factor precursor and initiate hepatocyte growth factor–Met signaling.
[ACS Applied Materials & interfaces] |
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| Estrogen receptor α (ERα) can oppose mineralocorticoid receptor (MR) function, therefore, scientists hypothesized that ERα mediated the benefits of endothelial MR deficiency.
[Hypertension] |
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| Researchers outlined a simple new technique of isolating mouse BMEC primary culture and a suitable method to evaluate the function and dysregulation of BMEC in in vitro studies using mouse models.
[Stem Cell Research & Therapy] |
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| The authors found that intra‐articular injection of baicalein ameliorated subchondral bone remodeling. Baicalein impaired angiogenesis of endothelial cells and inhibited proliferation of synovial cells.
[Journal of Cellular and Molecular Medicine] |
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| Scientists showed that obesity led to neutrophil-dependent impairment of vascular integrity through loss of endothelial adhesions, enabling cancer cell extravasation into the lung.
[Nature Cancer] |
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| Investigators found that cisplatin and 5-fluorouracil could induce fibroblast differentiation toward myofibroblasts via CCAAT/enhancer-binding protein delta and consequently promoted proliferation, migration, and in vitro tube formation of vascular endothelial cells and angiogenesis in vivo.
[Cell Death & Discovery] |
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| Scientists discuss how the synergy between inflammation and thrombosis drives thrombotic diseases. They focus on the huge potential of anti-inflammatory strategies to target cardiovascular pathologies.
[Nature Reviews Cardiology] |
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| The authors highlight the phenotype and function of high endothelial venules (HEVs) in homeostatic, inflamed and tumor-draining lymph nodes, and those of HEV-like blood vessels in chronic inflammatory diseases.
[Angiogenesis] |
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| AbCellera and Angios GmbH announced that they have entered into a multi-year, multi-target collaboration to facilitate the discovery of monoclonal and bispecific antibodies for vascular diseases of the eye.
[AbCellera (BusinessWire, Inc)] |
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| June 21 – 24, 2021
Virtual |
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| University of Exeter – Exeter, United Kingdom |
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| | Karolinska Institutet – Solna, Sweden |
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| | Stanford University – Stanford, California, United States |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| | Aarhus University – Copenhagen, Denmark |
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