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| Researchers provided a reference atlas of human lung endothelial cells to facilitate a better understanding of the phenotypic diversity and composition of cells comprising the lung endothelium.
[Circulation] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors described the unexpected crosstalk between the copper transporter ATP7A, autophagy, and VEGFR2 degradation.
[Nature Communications] |
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| Researchers showed that Aß plaque-associated NPA locally disassembles blood vessels, leaving behind vascular scars, and that microglial phagocytosis contributes to the local loss of endothelial cells.
[Nature Communications] |
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| By combining spatial cell sorting with transcriptomics and quantitative proteomics/phosphoproteomics, investigators established the spatially resolved proteome landscape of the liver endothelium, yielding deep mechanistic insight into zonated vascular signaling mechanisms.
[Developmental Cell] |
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| The authors performed single-cell RNA sequencing to characterize the heterogeneity of endothelial cells in bleomycin-induced lung fibrosis in rats.
[Angiogenesis] |
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| Using tissue-specific genetic ablation in endothelial cells, scientists investigated in vivo the role of tumor progression locus 2 (Tpl2), a mitogen-activated protein kinase kinase kinase member with pleiotropic effects in inflammation and cancer.
[Cell Reports] |
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| Researchers explored for the first time the function of nuclear exosomes HMGB3 in tumor angiogenesis involved in nasopharyngeal carcinoma metastasis using a series of in vitro experiments with nasopharyngeal carcinoma cell lines and clinical specimens.
[Cell Death & Disease] |
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| RNA-sequencing datasets in the NCBI GEO repository were first analyzed; upregulation of cannabinoid receptors was observed in both primary and metastatic colorectal cancer tumor tissues.
[Cancer Gene Therapy] |
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| Scientists hypothesized that NRG1 could compensate for endothelial nitric oxide (NO) synthase (eNOS) deficiency. They characterized eNOS null and wild type mice by cardiac ultrasound and histology and determined circulating NRG1 levels.
[American Journal of Physiology-Heart and Circulatory Physiology] |
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| The authors comprehensively assessed the vasculature in two distinct kidney organoid models as well as in explanted embryonic kidneys.
[Developmental Biology] |
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| Investigators characterized venous malformation endothelial and mural cell expression by performing a comprehensive expression analysis of venous malformation vasculature.
[PLOS ONE] |
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| Scientists used single-cell metabolic imaging to measure glycolysis in individual endothelial cells with genetically encoded biosensors capable of deciphering metabolic heterogeneity at subcellular resolution.
[Nature Metabolism] |
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| The authors review and compare five bioactive elements with respect to their effect on the angiogenic behavior of endothelial cells when incorporated on the surface of biomaterials.
[Advanced Healthcare Materials] |
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| Omeros Corporation announced preliminary results from the second cohort of critically ill COVID-19 patients treated with narsoplimab in Bergamo, Italy.
[Omeros Corporation (BusinessWire, Inc.)] |
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| June 21 – 24, 2021
Virtual |
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| Gilead Sciences, Inc. – Foster City, California, United States |
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| Brigham and Women’s Hospital – Boston, US Minor Outlying Islands |
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| | University of Nebraska Medical Center – Omaha, Nebraska, United States |
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| | Stanford University – Stanford, California, United States |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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