 | | Vol. 6.20 – 14 June, 2021 |
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| The authors showed that long, perfusable tubes only developed if hydrogel adhesiveness and degradability were fine-tuned to support the initial collective invasion of endothelial cells and, at the same time, allowed for matrix remodeling to permit the opening of lumens.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that platelets expressing C5aR1 exert an inhibitory effect on endothelial cell functions such as migration and 2D and 3D tube formation.
[Nature Communications] |
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| The authors reported that SRC homology 2-containing Protein Tyrosine Phosphatases (SHP2 was an essential promoter of endothelial cell survival and growth in the remodeling tumor vasculature.
[EMBO Molecular Medicine] |
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| Researchers developed F4L5.13, a tetravalent antibody designed to induce FZD4 and LRP5 proximity in such a way as to trigger βcatenin signaling. Treatment of cultured endothelial cells with F4L5.13 rescued permeability induced by VEGF in part by promoting surface expression of junction proteins.
[EMBO Molecular Medicine] |
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| The authors analyzed the miR-126/CXCL12 axis and compared impacts of both miR-126-3p and miR-126-5p strands effects in CXCL12-induced angiogenesis.
[Journal of Cellular and Molecular Medicine] |
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| Investigators explored the mechanisms through which chondrocytes regulated endothelial cell migration and angiogenesis in osteoarthritis.
[Bone] |
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| A downregulation of SNHG15 was observed in the ischemic hind limb of diabetic mice and high glucose-treated HUVECs.
[Laboratory Investigation] |
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| Atomic force microscopy pulling was used to apply force to glypican-1 and PECAM-1 on the surface of human umbilical vein endothelial cells and nitric oxide was measured using a fluorescent reporter dye.
[Scientific Reports] |
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| Researchers explored the association between sitting patterns and microRNAs isolated from endothelial cell-derived extracellular vesicles.
[Scientific Reports] |
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| Scientists utilized a β3-endonexin mutant carrying a defective nuclear localization sequence to disrupt its nuclear localization and evaluated its ability to promote HUVEC proliferation and formation of tube-like vascular structures.
[Biochemical and Biophysical Research Communications] |
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| Researchers used targeted next-generation sequencing or digital droplet polymerase chain reaction to screen for somatic PIK3CA mutations on DNA extracted from resected lesional tissue or lymphatic endothelial cells isolated from lesions.
[Orphanet Journal of Rare Disease] |
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| Scientists discuss the contributions of inflammation and infection to venous thromboembolism.
[Circulation Research] |
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| The National Institutes of Health (NIH) awarded Lydia Kavraki, PhD, of Rice University’s Brown School of Engineering, a U01 grant to develop a new approach to model and analyze protein-ligand interactions in cancer research. The end goal is to create a proteomics toolkit, PROTEAN-CR, focused on the structural analysis of protein-ligand interactions.
[Genetic Engineering & Biotechnology News] |
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| September 24 – 27, 2021
Kloster Seeon, Germany |
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| | University of Oslo – Oslo, Norway |
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| | University of Pisa – Pisa, Italy |
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| Gilead Sciences, Inc. – Foster City, California, United States |
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| Brigham and Women’s Hospital – Boston, US Minor Outlying Islands |
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| | University of Nebraska Medical Center – Omaha, Nebraska. United States |
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