Endothelial Cell News Volume 6.21 | Jun 21 2021

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    Justin.choi
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    2021-06-21 | ENDOCN 6.21


    Endothelial Cell News by STEMCELL Technologies
    Vol. 6.21 – 21 June, 2021
    TOP STORY

    Multifunctional 3D-Printed Wound Dressings

    Hydrogel wound dressings carrying antibacterial silver nanoparticles and VEGF with predetermined release profiles were utilized to study the physiological response of the wound in a mouse model.
    [ACS Nano]

    AbstractGraphical Abstract

    CloneR for Enhancing the Cloning Efficiency and Single-Cell Survival of hPSCs
    PUBLICATIONSRanked by the impact factor of the journal

    Molecular Tension in Syndecan-1 Is Regulated by Extracellular Mechanical Cues and Fluidic Shear Stress

    Scientists examined the changes in mechanical tension of syndecan-1, a cell surface proteoglycan that is an integral part of the glycocalyx, in response to substrate stiffness and fluidic shear stress.
    [Biomaterials]

    Abstract

    Sequential Regulation of Hemogenic Fate and Hematopoietic Stem and Progenitor Cell Formation from Arterial Endothelium by Ezh1/2

    Single-cell RNA sequencing across ezh1 genotypes revealed a dropout of ezh1+/− cells among arterial endothelium associated with positive regulation of gene transcription.
    [Stem Cell Reports]

    Full Article

    Delivery of Endothelial Cell-Laden Microgel Elicits Angiogenesis in Self-Assembling Ultrashort Peptide Hydrogels In Vitro

    Th authors used a modular tissue-engineering approach, embedding self-assembling ultrashort peptides (SUP) microgels loaded with HUVECs into a 3D SUP hydrogel containing human dermal fibroblast neonatal cells to trigger angiogenesis.
    [ACS Applied Materials & Interfaces]

    AbstractGraphical Abstract

    A Neutrophil-Mimetic Magnetic Nanoprobe for Molecular Magnetic Resonance Imaging of Stroke-Induced Neuroinflammation

    Inspired by the specific neutrophil-endothelium interaction, investigators designed neutrophil-camouflaged magnetic nanoprobes that could be used to target activated endothelial cells for improved neuroinflammation imaging.
    [Biomaterials Science]

    AbstractGraphical Abstract

    Tumor Irradiation Combined with Vascular-Targeted Photodynamic Therapy Enhances Antitumor Effects in Pre-Clinical Prostate Cancer

    Researchers investigated whether sequential delivery of fractionated radiotherapy (FRT) followed by vascular-targeted photodynamic therapy (VTP) days later improved flank TRAMP-C1 prostate cancer tumor allograft control compared to monotherapy with FRT or VTP.
    [British Journal of Cancer]

    Full Article

    Epigenetic Down-Regulation of microRNA-126 in Scleroderma Endothelial Cells Is Associated with Impaired Responses to VEGF and Defective Angiogenesis

    MiR-126 expression, as well as EGFL7, in systemic sclerosis scleroderma-MVECs and skin, was significantly down-regulated in association with increased expression of sprouty-related protein-1 and phosphoinositide-3 kinase regulatory subunit 2 and diminished response to VEGF.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    High Fluid Shear Stress Prevents Atherosclerotic Plaque Formation by Promoting Endothelium Denudation and Synthetic Phenotype of Vascular Smooth Muscle Cells

    The authors investigated the role of high shear stress (HSS) in atherosclerotic plaque formation. In vitro modeling used HUVECs and vascular smooth muscle cells exposed to HSS using a parallel‑plate flow system.
    [Molecular Medicine Reports]

    AbstractFull Article

    Human Induced Pluripotent Stem Cells-Derived Corneal Endothelial-Like Cells Promote Corneal Transparency in a Rabbit Model of Bullous Keratopath

    Researchers used a modified approach to differentiate induced pluripotent stem cells into corneal endothelial-like cells (CECs). After the identification of differentiated CECs, the CECs were injected into the anterior chambers of the eyes of a rabbit model of bullous keratopathy.
    [Stem Cells and Development]

    Abstract

    Derive and expand human endothelial cells with EC-Cultâ„¢-XF Culture Kit.
    REVIEWS

    Novel Insights for the Role of Nitric Oxide in Placental Vascular Function during and beyond Pregnancy

    Scientists discuss the evidence for nitric oxide as a critical player of placental development and function, with a special focus on endothelial nitric oxide synthase vascular effects.
    [Journal of Cellular Physiology]

    Abstract

    The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology

    The emerging role of bone morphogenetic proteins (BMP) signaling in lymphatic vessel biology will be highlighted within the framework of BMP signaling in the circulatory vasculature.
    [International Journal of Molecular Sciences]

    Full Article

    Integration of Substrate- and Flow-Derived Stresses in Endothelial Cell Mechanobiology

    The authors review endothelial cell responses to substrate-derived biophysical cues, namely topography, curvature, and stiffness, as well as to flow-derived stresses, notably shear stress, pressure, and tensile stresses.
    [Communications Biology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Five VP&S Teams Awarded Vagelos Precision Medicine Grants

    The annual Vagelos Precision Medicine Pilot Grants have been awarded to five teams of VP&S researchers conducting innovative basic science, translational, and clinical research across multiple diseases, from novel cancer therapeutics to health disparities research.
    [Columbia University Irving Medical Center]

    Press Release

    FEATURED EVENT

    Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Lung Diseases

    July 12 – 15, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cardiac Fibrosis and Valvular Diseases

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    Postdoctoral Position – Cell and Developmental Biology

    University of Pisa – Pisa, Italy

    Postdoctoral Fellow – Asthma

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Senior Associate Scientist – Fibrosis Biology

    Gilead Sciences, Inc. – Foster City, California, United States

    Postdoctoral Research Associate – Cardiac Remodeling

    University of Nebraska Medical Center – Omaha, Nebraska. United States

    > See All Jobs

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