| Vol. 6.22 – 28 June, 2021 |
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| Scientists developed and applied an approach where single-walled carbon nanotubes played a dual role-that of an engineered nanomaterials undergoing intracellular processing, in addition to functioning as the signal transduction element reporting these events in individual cells with single organelle resolution. [ACS Nano] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators reported the first model of the blood-brain barrier featuring both isogenic human induced pluripotent stem cell-derived cells and continuous barrier integrity monitoring with under 2 min temporal resolution. [Small] |
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| Using PRKCB2 as bait, scientists identified functional ortholog of veal2 in humans from HUVECs and named it as VEAL2. [EMBO Journal] |
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| The authors showed that TNF-α strongly induced human endothelial cells to undergo endothelial–mesenchymal transition. They also showed that TNF-α-induced EndMT was reversible. Furthermore, TNF-α treatment of orthotopic mice resulted in an important increase in the stroma, including cancer-associated fibroblasts. [Cell Death & Disease] |
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| Mice were followed for xenogeneic graft-versus-host disease score and survival. Human T-cell engraftment and as well as human T-cell subtypes were monitored in blood on days 14, 21, and 28 after transplantation. [Bone Marrow Transplantation] |
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| Researchers characterized the functional activity of nicotinamide N-methyltransferase (NNMT) in the endothelium and tested whether NNMT regulated endothelial cell viability. [Biochimica et Biophysica Acta (BBA) – Molecular Cell Research] |
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| To explore more efficacious and long-lasting treatment of corneal neovascularization (CoNV), investigators employed rAAV2 and rAAV8 vectors to mediate KH902 expression via a single intrastromal injection and investigated its anti-angiogenic effects and safety in both alkali burn- and suture-induced CoNV mouse models. [Molecular Therapy-Methods & Clinical Development] |
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| The proportion of Th17 cells in the spleen and the expression levels of IL-17A, IL-6, and vascular cell adhesion molecule- in mice of different ages were increased with aging. [Laboratory Investigation] |
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| The authors aimed at dissecting the cellular and molecular mechanisms driving blood flow-dependent endothelial remodeling. Transcriptomic analysis of endothelial cells revealed that blood flow enhanced VEGFR signaling. [Scientific Reports] |
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| A porcine endothelial cell was characterized and immortalized for genetic modification. Five genes including GGTA1, CMAH, β4galNT2, SLA-I α chain, and β2-microglobulin that are responsible for the production of major xenoantigens were sequentially disrupted in immortalized porcine endothelial cells using CRISPR/Cas9 technology. [Scientific Reports] |
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| Selenium nanoparticles could competitively inhibit the binding of bFGF to fibroblast growth factor receptor through direct binding to bFGF, down-regulate the expression of bFGF in HUVEC cells, and significantly reduce the MAPK/Erk and P13K/AKT pathways activation of signaling molecules to regulate HUVEC cell migration and angiogenesis. [Nanotechnology] |
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| The authors investigated in vitro the effects of the alpha-1,2- mannosidase 1 inhibitor Kifunensine and brefeldin A in the LPS-induced endothelial breakdown. [American Journal of Physiology-Cell Physiology] |
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| Researchers found that 41 nuclear proteins are specifically enriched at the Ripk3 locus, including the Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway components NFκB1 and IKBKG. [PLOS ONE] |
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| Scientists discuss the cellular and molecular mechanisms involved in vascular network formation and how these intrinsic mechanisms are influenced by hemodynamic forces provided by pressurized blood flow. [Seminars in Cell & Developmental Biology] |
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| Terns Pharmaceuticals, Inc. announced the initiation of patient dosing in the AVIATION Trial, a Phase Ib clinical trial evaluating TERN-201, an orally-administered, highly selective inhibitor of vascular adhesion protein-1 (VAP-1) in patients with NASH. [Terns Pharmaceuticals, Inc.] |
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| Amneal Pharmaceuticals, Inc. announced the US FDA has accepted for review the Biologics License Application for Bevacizumab. Amneal is seeking approval for Bevacizumab for the treatment of metastatic colorectal cancer, in combination with intravenous fluorouracil-based chemotherapy for first- or second-line treatment. [Amneal Pharmaceuticals, Inc.] |
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| September 6 – 10, 2021 Virtual |
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| The European Molecular Biology Laboratory – Barcelona, Spain |
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| Boston Children’s Hospital – Boston, Massachusetts, United States |
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| University of Pisa- Pisa, Italy |
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| Stanford University – Stanford, California, United States |
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| Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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