 | | Vol. 6.24 – 12 July, 2021 |
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| Investigators generated tissue-specific “loss-” and “gain-of-function” models for eNOS by using cell-specific Cre-induced gene inactivation or reactivation.
[Circulation] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated that the expression of kruppel0like factor (KLF2) was reduced and monocyte adhesion was increased in endothelial cells treated with COVID-19 patient serum due to elevated levels of pro-adhesive molecules, ICAM1 and VCAM1.
[Signal Transduction and Targeted Therapy] |
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| Researchers used single-cell RNA sequencing at key developmental timepoints to interrogate cellular contributions to coronary vessel patterning and maturation.
[Nature Communications] |
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| Scientists showed that cerebrovascular endothelial cell-specific deletion of phosphatase and tensin homolog (Pten) resulted in a dramatic increase in vesicular transcytosis by the reduction of major facilitator superfamily domain-containing 2a, leading to increased transcellular permeability of the blood-brain barrier.
[Cell Reports] |
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| Through in vitro tests, investigators found that copper-doped bioactive glass enhanced angiogenesis by activating the pro-inflammatory environment and the HIF-1α pathway of human umbilical vein endothelial cells.
[Biomaterials Science] |
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| The authors cultured rat Schwann cells, aortic endothelial cells, and bone marrow-derived mesenchymal stem cells (BM-MSCs) and then obtained BM-MSC-derived induced endothelial cells and induced osteoblasts.
[Stem Cell Research & Therapy] |
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| Human umbilical vein endothelial cells (HUVECs) elongated, activated TAGLN promoter and increased TAGLN transcripts in angiogenesis model. Genetic disruption of TAGLN augmented angiogenic behaviors of HUVECs, as did the disruption of TAGLN2 and TAGLN3 genes.
[Journal of Cell Science] |
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| Researchers integrated text mining data, protein-protein interaction networks and multi-experiment microarray data to specify candidate genes that were involved in VEGFA/VEGFR2 signalling pathways.
[Journal of Cellular and Molecular Medicine] |
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| Downregulation of miR-15b-5p under high glucose conditions promoted proliferation, migration, and tube formation of human retinal vascular endothelial cells.
[Journal of Translational Medicine] |
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| In MC38 tumors, only endothelial cells (ECs) strongly express APJ, a cognate receptor for Apelin, indicating that EC-derived Apelin might regulate tumor formation in an autocrine manner.
[Scientific Reports] |
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| Investigators discuss the effects of fatty acids on four components of the T cell response – metabolism, activation, proliferation and polarization – and the influence of these changes on the pathogenesis of atherosclerosis.
[Nature Reviews Cardiology] |
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| Scientists highlight the distinct contributions of IL-6 signaling to the pathogenesis of several types of cytokine storms and discuss potential therapeutic strategies for the management of cytokine storms, including those associated with sepsis and COVID-19.
[Experimental & Molecular Medicine] |
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| Prothena Corporation plc and Novo Nordisk A/S announced that the companies have entered into a definitive purchase agreement under which Novo Nordisk has acquired Prothena’s clinical stage antibody PRX004 and broader ATTR amyloidosis programme. Novo Nordisk will initially focus on the clinical development of PRX004 in ATTR cardiomyopathy.
[Novo Nordisk A/S] |
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| November 15 – 19, 2021
Virtual |
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| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| | Stanford University – Palo Alto, California, United States |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | The European Molecular Biology Laboratory – Barcelona, Spain |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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